Röntgentherapie der Basaliome, spinozellulären Karzinome und Keratoakanthome

Soft x-ray therapy for cutaneous basal cell and squamous cell carcinomas

“…Some authors use fractionation schedules with definite total doses; others vary the total dose. 8,9,32,34 The tumor regression under treatment 15 or the development of erythema 23 is taken into account. Some drawbacks of our approach have to be admitted; we cannot monitor the complete degeneration of the tumor under treatment with exact precision.…”

Strahlentherapie des Basalzellkarzinoms Lokale Kontrolle und kosmetisches Ergebnis

“…Als lokale Therapiemaßnah-me stehen in erster Linie die speziellen mikrochirurgischen Verfahren nach Moh zur Verfügung; andere Möglichkeiten der lokalen Exzision des Tumors bestehen in Form der Kürettage, Elektrodesikkation, Kryo-oder Lasertherapie [2,6,8,9,11,14,15,25,26,35]. Falls operative Verfahren nicht möglich oder erwünscht sind, kommt die lokale Radiotherapie mit Orthovoltphotonen (50-200 kV) [7,10,18,[21][22][23][29][30][31][32][33], Elektronen (3-10 MeV) [5,7,21,22] eines Linearbeschleunigers oder Brachytherapie mit Iridium-192-Seeds [3,4] zur Anwendung. Zu den bislang weniger bewährten Therapieformen zählen die lokale Applikation von Isoretinoiden, Interferon α und Zytostatika, wie z.…”

“…Die Morbidität der Erkrankung ist anfangs zwar gering, nimmt aber mit dem Fortschreiten des Tumorwachstums deutlich zu. Die Mortalitätsrate liegt jedoch unter 0,1%, da die Tumoren fast nur lokal destruierend wachsen [2,10,21,32,33].…”

Office Radiotherapy of Cutaneous Carcinomas

“…Patients do not require hospitalization or anesthesia, nor do they require sophisticated reconstructive procedures. Cosmetic results are often excellent, primarily because radiotherapy does not change the contour of the treated area and it preserves the normal surrounding tissue 2–7 . Surgery often requires the removal of fairly large lateral and deep margins which can preclude a good cosmetic result 8 .…”

“…The radiation quality is adapted to the depth of the lesion (see Part I). In most patients with early carcinomas of the nose, radiation qualities between 0.4 and 1 mm of Al HVL are satisfactory ( D 1/2 , 6–15 mm); more penetrating radiation is rarely needed 4,13,16 . Tumors in the nasolabial fold often extend deeper than clinically expected and a radiation quality of at least 1 mm of Al HVL is usually preferred in this location.…”