Room Decontamination Using an Ultraviolet-C Device with Short Ultraviolet Exposure Time

Rutala, William A.; Gergen, Maria F.; Tande, Brian M.; Weber, David J.

doi:10.1086/677149

Cited by 41 publications

(42 citation statements)

References 8 publications

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“…9,11,13,15,16 A strength of this study is the real-world evaluation of 2 UVC machines and the parallel laboratory study using carrier disks and organisms suspended in a protein suspension. It also supports the conclusions of Nerandzic, Sitzlar, and colleagues 9,17 that UVC emitters should be used as adjuncts to traditional cleaning.…”

Section: Discussionmentioning

confidence: 99%

“…8 Their effectiveness in reducing ARO bioburden in clinical settings has also been documented. [9][10][11][12][13] With the exception of 26 MRSA isolation rooms in the Nerandzic et al study, these studies did not assess the impact of discharge cleaning prior to UVC decontamination and they did not specifically assess the effectiveness in the presence of a known protein load. 9 We describe a prospective observational study at a tertiary care hospital that used 2 commercial UVC devices to evaluate the incremental benefit of UVC decontamination in MRSA, VRE, and CD isolation rooms.…”

Section: Introductionmentioning

confidence: 99%

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Postdischarge decontamination of MRSA, VRE, and Clostridium difficile isolation rooms using 2 commercially available automated ultraviolet-C–emitting devices

Wong

Woznow

Petrie³

et al. 2016

American Journal of Infection Control

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Postdischarge decontamination of MRSA, VRE, and Clostridium difficile isolation rooms using 2 commercially available automated ultraviolet-C–emitting devices

Wong

Woznow

Petrie³

et al. 2016

American Journal of Infection Control

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“…Multiple studies have assessed the effectiveness of UV devices to inactivate microbes inoculated onto various test surfaces which are then placed in a typical hospital room (Table 1). [27][28][29][30][31][32][33] In general, the inoculating doses were >4 log10 in order to fully assess the level of bacterial inactivation. The most commonly tested organisms were epidemiologic important health care-associated pathogens and included MRSA, VRE, C difficile, and Acinetobacter spp.…”

Section: Uv Device Effectiveness To Reduce Intentionally Contaminatedmentioning

confidence: 99%

Effectiveness of ultraviolet devices and hydrogen peroxide systems for terminal room decontamination: Focus on clinical trials

Weber

Rutala

Anderson

et al. 2016

American Journal of Infection Control

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164

148

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Over the last decade, substantial scientific evidence has accumulated that indicates contamination of environmental surfaces in hospital rooms plays an important role in the transmission of key health care-associated pathogens (eg, methicillin-resistant Staphylococcus aureus, vancomycin-resistant enterococci, Clostridium difficile, Acinetobacter spp). For example, a patient admitted to a room previously occupied by a patient colonized or infected with one of these pathogens has a higher risk for acquiring one of these pathogens than a patient admitted to a room whose previous occupant was not colonized or infected. This risk is not surprising because multiple studies have demonstrated that surfaces in hospital rooms are poorly cleaned during terminal cleaning. To reduce surface contamination after terminal cleaning, no touch methods of room disinfection have been developed. This article will review the no touch methods, ultraviolet light devices, and hydrogen peroxide systems, with a focus on clinical trials which have used patient colonization or infection as an outcome. Multiple studies have demonstrated that ultraviolet light devices and hydrogen peroxide systems have been shown to inactivate microbes experimentally plated on carrier materials and placed in hospital rooms and to decontaminate surfaces in hospital rooms naturally contaminated with multidrug-resistant pathogens. A growing number of clinical studies have demonstrated that ultraviolet devices and hydrogen peroxide systems when used for terminal disinfection can reduce colonization or health care-associated infections in patients admitted to these hospital rooms.

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“…1 Under experimental conditions, these devices have demonstrated efficacy in killing a variety of bacterial pathogens, including Clostridium difficile spores. [2][3][4][5][6][7][8][9][10] In hospital rooms, use of the devices has been shown to reduce the burden of pathogens on surfaces. [2][3][4][6][7][8][11][12][13] There have also been some reports of use of UV-C devices associated with reductions in healthcare-associated infections.…”

mentioning

confidence: 99%

“…For example, inoculated surfaces have included glass, steel, and Formica carriers or bench countertops, spreading of the inoculum has varied from areas of 4 mm 2 to 25 cm 2 , and inoculated carriers have been oriented in parallel or perpendicular to the bulbs. [2][3][4][5][6][7][8][9][10] Although it is known that UV-C efficacy is affected by distance and shading, it is not known if variation in other test conditions affect pathogen killing. Here, we compared the effectiveness of 2 UV-C room decontamination devices and evaluated the effect of variation in test methods on performance of 1 of the devices.…”

mentioning

confidence: 99%

Effect of Variation in Test Methods on Performance of Ultraviolet-C Radiation Room Decontamination

Cadnum

Tomas²,

Sankar

et al. 2016

Infect. Control Hosp. Epidemiol.

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objective. To determine the effect of variation in test methods on performance of an ultraviolet-C (UV-C) room decontamination device.design. Laboratory evaluation.methods. We compared the efficacy of 2 UV-C room decontamination devices with low pressure mercury gas bulbs. For 1 of the devices, we evaluated the effect of variation in spreading of the inoculum, carrier orientation relative to the device, type of organic load, type of carrier, height of carrier, and uninterrupted versus interrupted exposures on measured UV-C killing of methicillin-resistant Staphylococcus aureus and Clostridium difficile spores.results. The 2 UV-C room decontamination devices achieved similar log 10 colony-forming unit reductions in the pathogens with exposure times ranging from 5 to 40 minutes. On steel carriers, spreading of the inoculum over a larger surface area significantly enhanced killing of both pathogens, such that a 10-minute exposure on a 22-mm 2 disk resulted in greater than 2 log reduction in C. difficile spores. Orientation of carriers in parallel rather than perpendicular with the UV-C lamps significantly enhanced killing of both pathogens. Different types of organic load also significantly affected measured organism reductions, whereas type of carrier, variation in carrier height, and interrupted exposure cycles did not.conclusions. Variation in test methods can significantly impact measured reductions in pathogens by UV-C devices during experimental testing. Our findings highlight the need for standardized laboratory methods for testing the efficacy of UV-C devices and for evaluations of the efficacy of short UV-C exposure times in real-world settings.

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Room Decontamination Using an Ultraviolet-C Device with Short Ultraviolet Exposure Time

Cited by 41 publications

References 8 publications

Postdischarge decontamination of MRSA, VRE, and Clostridium difficile isolation rooms using 2 commercially available automated ultraviolet-C–emitting devices

Postdischarge decontamination of MRSA, VRE, and Clostridium difficile isolation rooms using 2 commercially available automated ultraviolet-C–emitting devices

Effectiveness of ultraviolet devices and hydrogen peroxide systems for terminal room decontamination: Focus on clinical trials

Effect of Variation in Test Methods on Performance of Ultraviolet-C Radiation Room Decontamination

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