Room temperature deoxofluorination of aromatic aldehydes with XtalFluor-E under highly concentrated conditions

Thibeault, Olivier; Berger, Marie-Rose Ouellet-Du; Gonay, Marie; Paquin, Jean‐François

doi:10.1039/d3ob00859b

Org. Biomol. Chem.

2023

DOI: 10.1039/d3ob00859b

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Room temperature deoxofluorination of aromatic aldehydes with XtalFluor-E under highly concentrated conditions

Olivier Thibeault

Marie-Rose Ouellet-Du Berger

Marie Gonay

et al.

Abstract: The room temperature synthesis of difluoromethyl-containing compounds using the deoxofluorination reaction of aromatic aldehydes using XtalFluor-E under highly concentrated conditions is described.

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Deoxyfluorination: A Detailed Overview of Recent Developments

Tavčar,

Jelen

2024

Synthesis

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Fluorine organic compounds have been a predominant force of pharmaceutical chemistry for modern drug design, with an increasing amount of fluorine-containing compounds entering the market. Methodologies for fluorine atom incorporation into organic molecules are still challenging to date and thus represent an important research area. Deoxyfluorination serves as a useful tool for the construction of carbon–fluorine bonds in biologically active molecules by converting a common hydroxyl group into the corresponding fluoride. In this review, we have summarized and categorized deoxyfluorination reaction protocols developed over the last decade (2015–2024) by the structural type of C–O bond deoxyfluorination, including substrates like alcohols, phenols, ketones, aldehydes, and carboxylic acids.1 Introduction2 Deoxyfluorination of C(sp3)–O Bonds2.1 Alcohols2.2 Alcohol Derivatives3 Deoxyfluorination of C(sp2)–O Bonds3.1 Phenols3.2 Phenol Derivatives3.3 Aldehydes and Ketones3.4 Carboxylic Acids4 Conclusions

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Deoxyfluorination: A Detailed Overview of Recent Developments

Tavčar,

Jelen

2024

Synthesis

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Room temperature deoxofluorination of aromatic aldehydes with XtalFluor-E under highly concentrated conditions

Abstract: The room temperature synthesis of difluoromethyl-containing compounds using the deoxofluorination reaction of aromatic aldehydes using XtalFluor-E under highly concentrated conditions is described.

Cited by 1 publication

References 64 publications

Deoxyfluorination: A Detailed Overview of Recent Developments

Deoxyfluorination: A Detailed Overview of Recent Developments

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