1976
DOI: 10.1007/bf01937728
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Roquefortine and isofumigaclavine A, metabolites fromPenicillium roqueforti

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Cited by 139 publications
(78 citation statements)
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“…The meleagrin and roquefortine groups, mainly isolated from Penicillium species, are biogenetically interrelated alkaloids [1][2][3][4][5][6][7] with promising biological properties, such as neurotoxic, 1 antibacterial, 8 cytochrome P450 inhibitory 9 and tubulin polymerization inhibitory activity. 10 We have previously reported on meleagrin B (5), a novel complex compound composed of a meleagrin alkaloid moiety and a rare diterpene moiety, from a deep ocean sediment-derived fungus Penicillium sp.…”
Section: Introductionmentioning
confidence: 99%
“…The meleagrin and roquefortine groups, mainly isolated from Penicillium species, are biogenetically interrelated alkaloids [1][2][3][4][5][6][7] with promising biological properties, such as neurotoxic, 1 antibacterial, 8 cytochrome P450 inhibitory 9 and tubulin polymerization inhibitory activity. 10 We have previously reported on meleagrin B (5), a novel complex compound composed of a meleagrin alkaloid moiety and a rare diterpene moiety, from a deep ocean sediment-derived fungus Penicillium sp.…”
Section: Introductionmentioning
confidence: 99%
“…Next to penicillins, secondary metabolites such as roquefortines and glandicolines were isolated from liquid cultures of P. chrysogenum, which show pharmaceutically interesting properties, such as neurotoxic (2), antimicrobial (3,4), and antitumor (5) activities. They are structurally closely related and arise from the roquefortine/meleagrin pathway, which contains a dimodular nonribosomal peptide synthetase flanked by six associated genes (6,7).…”
mentioning
confidence: 99%
“…6,12 Several reports attribute neurotoxic properties to roquefortine based on the work of Frayssinet and Frayssinet (cited by Scott et al, 1975). 15 The brief citation reported that intraperitoneal (IP) administration of 10 mg/kg of roquefortine caused muscle contractions and ataxia in mice. At higher doses (50-100 mg/kg) of roquefortine, prostration with intermittent seizures was reported.…”
mentioning
confidence: 99%