2019
DOI: 10.21203/rs.2.11911/v2
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ROS as a Novel Indicator to Predict Anticancer Drug Efficacy

Abstract: Background Mitochondria are considered a primary intracellular site of reactive oxygen species (ROS) generation. Generally, cancer cells with mitochondrial genetic abnormalities (copy number change and mutations) have escalated ROS levels compared to normal cells. Since high levels of ROS can trigger apoptosis, treating cancer cells with low doses of mitochondria-targeting / ROS-stimulating agents may offer cancer-specific therapy. This study aimed to investigate how baseline ROS levels might influence cancer … Show more

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Cited by 7 publications
(9 citation statements)
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“…These results suggest both concentration and time-dependent, persistent oxidative stress state, and agree with CR pro-oxidant role as proved by previous reports using cancer cell models [23,81,82,83]. To this point, higher baseline ROS levels were observed in the control untreated SW-948 cell line compared to HT-29 counterpart, which may indicate the cellular built-in differences in genetic platforms as reported in literature [86,87,88]. Interestingly, CAG nanocomposite demonstrated ability to induce ROS production in both tested cell lines which further corroborate previous findings using plant-based flavonoids [89].…”
Section: Discussionsupporting
confidence: 91%
“…These results suggest both concentration and time-dependent, persistent oxidative stress state, and agree with CR pro-oxidant role as proved by previous reports using cancer cell models [23,81,82,83]. To this point, higher baseline ROS levels were observed in the control untreated SW-948 cell line compared to HT-29 counterpart, which may indicate the cellular built-in differences in genetic platforms as reported in literature [86,87,88]. Interestingly, CAG nanocomposite demonstrated ability to induce ROS production in both tested cell lines which further corroborate previous findings using plant-based flavonoids [89].…”
Section: Discussionsupporting
confidence: 91%
“…Reactive oxygen species (ROS), generated through various extracellular and intracellular actions, function as very important intracellular messengers involved in the growth, differentiation, progression, metabolism, and death of cells [ 18 ]. In cancer cells, low doses of ROS promote cell proliferation in various cancer cell types, although excessive levels of ROS activate several signaling pathways involved in cell apoptosis [ 19 ].…”
Section: Resultsmentioning
confidence: 99%
“…Generally, tumor cells have increased ROS levels compared with those normal cells [5]. As high ROS levels trigger apoptosis, treating cancer cells with doses of mitoROSsimulating agents may offer a cancer-specific therapy [5]. The effects of various kinds of antioxidants on tumor growth have yielded mixed results.…”
Section: Introductionmentioning
confidence: 99%