ROS Balance Autoregulating Core–Shell CeO2@ZIF-8/Au Nanoplatform for Wound Repair

Zhou, Xi; Zhou, Quan; He, Zhaozhi; Xiao, Yi; Liu, Yan; Huang, Zhuohang; Sun, Yaoji; Wang, Jiawei; Zhao, Zhengdong; Liu, Xiaozhou; Zhou, Bin; Ren, Lei; Sun, Yu; Chen, Zhiwei; Zhang, Xingcai

doi:10.1007/s40820-024-01353-0

Cited by 7 publications

(1 citation statement)

References 61 publications

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“…Platinum acts as a catalyst to break down H 2 O 2 to produce oxygen for wound healing [118]. Deng et al have hydrogel-based wound dressing via encapsulation of Au@MOF nanoparticles for [116] improved antibacterial activities to heal wounds healing under visible light sources. They have reported that the composite hydrogel biomimic is the natural extracellular matrix and has performed not only antibacterial activities against Gram-positive and Gramnegative bacterial strains but also enhanced wound healing [112].…”

Section: Light-drivingmentioning

confidence: 99%

Metal-organic frameworks: synthesis, properties, wound dressing, challenges and scopes in advanced wound dressing

Khan,

Aslam,

Yasin

et al. 2024

Biomed. Mater.

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Wound healing is a critical but complex biological process of skin tissue repair and regeneration resulting from various systems working together at the cellular and molecular levels. Quick wound healing and the problems associated with traditional wound repair techniques are being overcome with multifunctional materials. Over time, this research area has drawn significant attention. Metal-organic frameworks (MOFs), owning to their peculiar physicochemical characteristics, are now considered a promising class of well-suited porous materials for wound healing in addition to their other biological applications. This detailed literature review provides an overview of the latest developments in MOFs for wound healing applications. We have discussed the synthesis, essential biomedical properties, wound-healing mechanism, MOF-based dressing materials, and their wound-healing applications. The possible major challenges and limitations of MOFs have been discussed, along with conclusions and future perspectives. This overview of the literature review addresses MOFs-based wound healing from several angles and covers the most current developments in the subject. The readers may discover how the MOFs advanced this discipline by producing more inventive, useful, and successful dressings. It influences the development of future generations of biomaterials for the healing and regeneration of skin wounds.

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Section: Light-drivingmentioning

confidence: 99%

Metal-organic frameworks: synthesis, properties, wound dressing, challenges and scopes in advanced wound dressing

Khan,

Aslam,

Yasin

et al. 2024

Biomed. Mater.

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Collaboration in Contradiction: Self‐Adaptive Synergistic ROS Generation and Scavenge Balancing Strategies Used for the Infected Wounds Treatment

Wang,

Liu,

Yang

et al. 2024

Adv Healthcare Materials

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The rational utilization of ROS is key to treating infected wounds. Exogenous ROS can destroy bacterial structures, quickly kill bacteria, and inhibit secondary infections. However, excess ROS at the wound will cause a secondary inflammatory response. Acute infections exacerbate this damage by increasing endogenous ROS, complicating the maintenance of ROS homeostasis. Therefore, regulating the balance of ROS production and scavenging in wounds has emerged as a promising strategy for wound treatment. Conventional ROS balancing platforms are mostly based on the “ all for one” strategy of functional superposition and lack self‐adaptability and integration. To subvert this conventional strategy, this study proposes a “one for all” self‐adaptive integrated photodynamic therapy (PDT)‐antioxidant model to actively regulate the ROS balance. A gelatin‐hyaluronic acid hydrogel embedded with Se‐modified cerium dioxide nanoparticles (Gel‐HA‐Se@CeO2 NPs) is designed for treating infected wounds. The Se@CeO2 NPs serve both as nanoenzymes and photosensitizers(PS). As nanoenzymes, they exhibit catalase and superoxide dismutase activities, converting hydrogen peroxide and superoxide anions into oxygen. As a PS, it synergizes with oxygen under NIR irradiation to rapidly produce singlet oxygen. Additionally, Se modification enhances the PDT effects by disrupting bacterial antioxidant systems. In vitro and in vivo experiments revealed that the ROS balance platform polarizes M1‐type macrophages to M2‐type macrophages, altering the wound microenvironment from proinflammatory to prohealing. RNA sequencing revealed that this hydrogel accelerated the reconstruction of the vascular network of the wound by activating the PI3K/AKT pathway and increasing VEGF secretion.This strategy is believed to be beneficial not only for infected wounds but also for treating other conditions that involve the regulation of reactive oxygen species, such as tumors and bacterial infections.

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Intelligent Carbon Dots with Switchable Photo‐Activated Oxidase‐Mimicking Activity and pH Responsive Antioxidant Activity Adaptive to the Wound Microenvironment for Selective Antibacterial Therapy

He,

Li,

et al. 2024

Advanced Science

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Intelligent antibacterial agent with controllable activities adaptive to the wound microenvironment is appealing to reduce drug resistance and enhance antibacterial efficiency. In this study, celery is chosen as the carbon source to construct celery‐based carbon dots (CECDs) with double activities, i.e., reactive oxygen species (ROS)‐production and ROS‐clearance activities. The ROS‐production capability of CECDs is dependent on the oxidase (OXD)‐mimicking activity, which is only photo‐activated and thus artificially controlled by light to avoid the production of excess ROS. Meanwhile, the optimal OXD‐mimicking activity occurrs at the pH of 5, close to microenvironmental pH at the bacterial infection site, which will enhance the antibacterial efficacy. On the other hand, CECDs exhibit the antioxidant activity at the neutral or weak alkaline pH, which will assist the healing of the wound. Thus, the conversion of ROS‐production and ROS‐clearance ability of CECDs can be dynamically and intelligently switched automatically with microenvironmental pH at different stages of treatment (from acid to neutral/weak basic). The proposed CECDs exert adorable selective antibacterial activity against Gram‐positive bacteria and satisfactory therapeutic effect on bacteria infected mice. This study paves a new avenue to design the intelligent antibacterial nanoagent sensitive to the infected microenvironmental condition, reducing drug resistance and assisting precise medicine.

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ROS Balance Autoregulating Core–Shell CeO2@ZIF-8/Au Nanoplatform for Wound Repair

Cited by 7 publications

References 61 publications

Metal-organic frameworks: synthesis, properties, wound dressing, challenges and scopes in advanced wound dressing

Metal-organic frameworks: synthesis, properties, wound dressing, challenges and scopes in advanced wound dressing

Collaboration in Contradiction: Self‐Adaptive Synergistic ROS Generation and Scavenge Balancing Strategies Used for the Infected Wounds Treatment

Intelligent Carbon Dots with Switchable Photo‐Activated Oxidase‐Mimicking Activity and pH Responsive Antioxidant Activity Adaptive to the Wound Microenvironment for Selective Antibacterial Therapy

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