2022
DOI: 10.1002/ctm2.905
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ROS‐driven cellular methane formation: Potential implications for health sciences

Abstract: Recently it has been proposed that methane might be produced by all living organisms via a mechanism driven by reactive oxygen species that arise through the metabolic activity of cells. Here, we summarise details of this novel reaction pathway and discuss its potential significance for clinical and health sciences. In particular, we highlight the role of oxidative stress in cellular methane formation. As several recent studies also demonstrated the anti‐inflammatory potential for exogenous methane‐based appro… Show more

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Cited by 9 publications
(5 citation statements)
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“…This process can currently only be made clearly visible by applying stable-isotope-tracing techniques to distinguish CH 4 formation in humans from that of microbes living in the gastrointestinal tract. Together with other recently published studies [17,38,94], it is becoming obvious that ROS-driven CH 4 formation might be a necessary phenomenon of aerobic life. Consequently, non-microbial aerobic CH 4 formation should be highly variable in time and source strength, as it may be an integral part of the cellular responses toward changes in oxidative status present in humans.…”
Section: Discussionmentioning
confidence: 73%
See 1 more Smart Citation
“…This process can currently only be made clearly visible by applying stable-isotope-tracing techniques to distinguish CH 4 formation in humans from that of microbes living in the gastrointestinal tract. Together with other recently published studies [17,38,94], it is becoming obvious that ROS-driven CH 4 formation might be a necessary phenomenon of aerobic life. Consequently, non-microbial aerobic CH 4 formation should be highly variable in time and source strength, as it may be an integral part of the cellular responses toward changes in oxidative status present in humans.…”
Section: Discussionmentioning
confidence: 73%
“…In parallel studies, CH 4 influenced several components of the endoplasmic reticulum-mitochondria-related pro-apoptotic signaling pathways, the oxidative phosphorylation capacity was more preserved, and the relative mRNA expression for hypoxia-and ER stress-associated genes (including HIF-1α) was significantly reduced [93]. For a detailed discussion regarding the potential applications of monitoring CH 4 in medical research and health sciences, see [18,38,94,95].…”
Section: Ros-induced Non-microbial Formation Of Ch 4 From Methylated ...mentioning
confidence: 99%
“…Today, oxidative stress caused by lifestyle factors such as smoking, lack of physical activity and unbalanced nutrition, as well as reactive oxygen species (ROS) produced during metabolic activities, are effective in the formation of various chronic diseases [19,20]. Diabetes Mellitus is a chronic endocrine disorder characterized by hyperglycemia that occurs due to problems in the secretion of the insulin hormone or increased insulin resistance [20,21].…”
Section: Introductionmentioning
confidence: 99%
“…13 The high levels of reactive oxygen species (ROS) during OS can lead to the impairment of macromolecules such as proteins, lipids and nucleic acids when cells resist apoptosis or undergo aging. [14][15][16][17] Maintaining the integrity of DNA or RNA, proteins and lipids is crucial for overall health and disease prevention. Prior research has highlighted the significant role of OS in various human diseases, including cancer.…”
Section: Introductionmentioning
confidence: 99%
“…OS can lead to cell senescence and apoptosis, 11,12 which serve as defense mechanisms to limit the growth of damaged cells, thereby preventing the propagation of genetic instability and damage to progeny cells 13 . The high levels of reactive oxygen species (ROS) during OS can lead to the impairment of macromolecules such as proteins, lipids and nucleic acids when cells resist apoptosis or undergo aging 14–17 . Maintaining the integrity of DNA or RNA, proteins and lipids is crucial for overall health and disease prevention.…”
Section: Introductionmentioning
confidence: 99%