ROS generation, lipid peroxidation and antioxidant enzyme activities in the aging brain

Leutner, Silke; Eckert, Anne; Müller, Wernér E.G.

doi:10.1007/s007020170015

Cited by 186 publications

(100 citation statements)

References 32 publications

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“…In the present study, increase in basal MDA levels both the regions of the old suggests the contribution of ROS in promoting brain aging. Our results are in concordance with that reported on studies using rat and mice brain [17,22]. Although we have not measured ROS, it may be appropriate to mention that in vitro stimulation by iron and H 2 O 2 in the young and old animals result in an age-related decrease in the magnitude of response, which are correlated to alterations in the fatty acid composition during aging.…”

Section: Discussionsupporting

confidence: 92%

“…The antioxidant system (AOS) spans over a wide range of mechanisms such as enzymic AOS which includes superoxide dismutase (SOD), glutathione peroxidase (GSH-Px) and catalase (CAT) to small molecular weight compounds such as Vitamin E and glutathione though in relatively low concentrations [6,32] when compared to other organs. Various investigators have determined the effects of aging [17] and exercise [33] on the antioxidant enzymes (AOEs) in the brain of rodents. Although physical exercise is beneficial to the body, it can generate free radicals [24,30] in the untrained.…”

Section: Introductionmentioning

confidence: 99%

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Regional responses in antioxidant system to exercise training and dietary Vitamin E in aging rat brain

Devi

Kiran

2004

Neurobiology of Aging

131

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We have evaluated the effect of exercise, Vitamin E and a combination of both on the antioxidant enzymes (AOEs)-superoxide dismutase (SOD), glutathione peroxidase (GSH-Px) and catalase (CAT) along with the products of lipid peroxidation (LP)-malondialdehyde (MDA) and lipofuscin-like auto fluorescent substances (LF-like AFS) in discrete brain regions of rats of 4 (young adults), 8 (old adults), 12 (middle-age) and 22 months (mos) old of age. Hippocampus (HC) showed greater increase in GSH-Px activity than cerebral cortex (CC) to exercise and Vitamin E and was irrespective of the age. A combination of both was effective in the CC of all age groups but not in the supplemented sedentary of 12-and 22-mo-olds. CAT activity increased significantly in the HC of supplemented and trained rats but not in the combination group of any age. SOD increased in both the regions of supplemented trainees. However, old were more benefited in terms of maximal elevation in the HC. Vitamin E reduced MDA content in both regions of adult. LF-like AFS decreased significantly in supplemented sedentary and trainees of all ages. Our results demonstrate that an age-related deficit in AOEs in the CC and HC can be overcome through Vitamin E plus exercise, and further suggests the rationale for looking at these markers of oxidative stress in several age-related neuronal diseases.

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Section: Discussionsupporting

confidence: 92%

Section: Introductionmentioning

confidence: 99%

Regional responses in antioxidant system to exercise training and dietary Vitamin E in aging rat brain

Devi

Kiran

2004

Neurobiology of Aging

131

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“…These results support the hypothesis that oxidative stress contributes to age-related impairment in learning and memory. Previous studies (11) have shown that oxidative stress increases almost linearly with age, by Ϸ40%, from 2-3 to 20-21 months of age in mice. Several studies (12,23,24,32) have also reported that chronic or subchronic treatment with a variety of antioxidants partially reversed age-related increase in markers of oxidative stress and decline in learning and memory in old mice.…”

Section: Discussionmentioning

confidence: 79%

Reversal of age-related learning deficits and brain oxidative stress in mice with superoxide dismutase/catalase mimetics

Liu

Liu²,

Bi³

et al. 2003

Proc. Natl. Acad. Sci. U.S.A.

336

215

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Oxidative stress has been implicated in cognitive impairment in both old experimental animals and aged humans. This implication has led to the notion that antioxidant defense mechanisms in the brain are not sufficient to prevent age-related increase in oxidative damage and that dietary intake of a variety of antioxidants might be beneficial for preserving brain function. Here we report a dramatic loss of learning and memory function from 8 to 11 months of age in mice, associated with marked increases in several markers of brain oxidative stress. Chronic systemic administration of two synthetic catalytic scavengers of reactive oxygen species, Eukarion experimental compounds EUK-189 and EUK-207, from 8 to 11 months almost completely reversed cognitive deficits and increase in oxidative stress taking place during this time period in brain. In particular, increase in protein oxidation was completely prevented, whereas increase in lipid peroxidation was decreased by Ϸ50%. In addition, we observed a significant negative correlation between contextual fear learning and levels of protein oxidation in brain. These results further support the role of reactive oxygen species in age-related learning impairment and suggest potential clinical applications for synthetic catalytic scavengers of reactive oxygen species.A ging in humans, as well as in experimental animals, is associated with a slow deterioration of cognitive performance and, in particular, of learning and memory (1-5). In humans, recent studies (6) have indicated the importance of impaired learning and memory processes, because 12% of humans with mild cognitive impairment will develop Alzheimer's disease as opposed to 2% of the general population. Oxidative damage has long been proposed to be critically involved in several pathological manifestations of aging (7,8). Numerous studies (9 -12) have indeed reported increases in protein oxidation and lipid peroxidation in various regions of aged mammalian brains. These findings have led to the notion that antioxidant defense mechanisms in the brain are not sufficient to prevent age-related increase in oxidative damage and that dietary intake of a variety of antioxidants might be beneficial for preserving brain function. In agreement with this idea, synthetic catalytic molecules that exhibit both superoxide dismutase (SOD) and catalase activity significantly increase the mean and maximum lifespan in Caenorhabditis elegans (13) and alleviate lethal oxidative pathologies in mice with genetically deleted . The present studies tested, in wild-type mice, the effects of such molecules on age-related learning and memory impairment, and on markers of oxidative damage in the brain. We found that C57BL͞6N Sim mice exhibit a dramatic decrease in learning and memory function between 8 and 11 months of age, accompanied by a marked increase in brain oxidative damage. Chronic treatment of mice with two recently developed SOD͞catalase mimetics over a 3-month period almost completely reversed the age-related decline in cognitive functi...

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“…Numerous studies have indeed reported increases in protein oxidation and lipid peroxidation in various regions of aged mammalian brains [22][23][24]. These findings have led to the notion that antioxidant defence mechanisms in the brain are not sufficient to prevent age-related increase in oxidative damage and that dietary intake of antioxidants might be beneficial for preserving brain function.…”

Section: Introductionmentioning

confidence: 99%

Neuroprotective effects of Tualang honey against oxidative stress and memory decline in young and aged rats exposed to noise stress

Azman

Zakaria

Othman

et al. 2018

Journal of Taibah University for Science

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The neuroprotective effects of Tualang honey in stress-induced young and aged rats were investigated. Tualang honey (200 mg/kg body weight) was administered for 28 days. Stressinduced rats were subjected to loud noise 100 dB(A) 4 hours daily for 14 days. Stress exposure significantly induced memory impairment, increased brain oxidation indices, and decreased antioxidant enzymes activities and neuronal density in mPFC, CA2 and CA3 hippocampal areas in both young and aged rats. The stressed rats treated with Tualang honey showed a significant decrease in stress hormone levels and brain oxidation indices, and increase in memory, antioxidant enzymes activities, and neuronal density in mPFC and hippocampus compared to the vehicle-treated stressed rats. The protective effect of Tualang honey was more prominent in young than aged rats. These results suggest the neuroprotective effects of Tualang honey against oxidative stress and memory decline due to stress exposure and/or ageing through its antioxidant property. ARTICLE HISTORY

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ROS generation, lipid peroxidation and antioxidant enzyme activities in the aging brain

Cited by 186 publications

References 32 publications

Regional responses in antioxidant system to exercise training and dietary Vitamin E in aging rat brain

Regional responses in antioxidant system to exercise training and dietary Vitamin E in aging rat brain

Reversal of age-related learning deficits and brain oxidative stress in mice with superoxide dismutase/catalase mimetics

Neuroprotective effects of Tualang honey against oxidative stress and memory decline in young and aged rats exposed to noise stress

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