2017
DOI: 10.1007/s00432-017-2464-9
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ROS-modulated therapeutic approaches in cancer treatment

Abstract: Cancer cells exhibit increased ROS stress and disturbed redox homeostasis which lead to ROS adaptations. ROS-dependent anticancer therapies including ROS scavenging anticancer therapy and ROS boosting anticancer therapy have shown promising results in vitro as well as in vivo. In addition, response to cancer therapy is modulated by the human microbiota which plays a critical role in systemic body functions.

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Cited by 238 publications
(159 citation statements)
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“…Agents that increase the levels of ROS in cancer cells lead to cytotoxicity to these cells [39,40]. We assessed the levels of ROS when 122.4 was combined with doxorubicin or etoposide or cisplatin in treating BS-24-1 cells.…”
Section: Resultsmentioning
confidence: 99%
“…Agents that increase the levels of ROS in cancer cells lead to cytotoxicity to these cells [39,40]. We assessed the levels of ROS when 122.4 was combined with doxorubicin or etoposide or cisplatin in treating BS-24-1 cells.…”
Section: Resultsmentioning
confidence: 99%
“…Superoxide is the precursor of ROS and is crucial to the oxidative chain reaction. Hydrogen peroxide is produced when superoxide is dismutated by the enzyme superoxide dismutase [46]. Here, both superoxide and hydrogen peroxide were elevated soon after combined treatment, which thereafter activated the antioxidant system.…”
Section: Discussionmentioning
confidence: 99%
“…It has been reported earlier that poly (xylitol sebacate) (PXS) were fabricated by the polycondensation of xylitol and sebacic acid showing desired performances. PXS exhibit even better in‐vitro biocompatibility …”
Section: Introductionmentioning
confidence: 99%