ROS-responsive Ag-TiO2 hybrid nanorods for enhanced photodynamic therapy of breast cancer and antimicrobial applications

Plasmon-enhanced nano-photosensitizers: game-changers in photodynamic therapy of cancers

“…Hou and colleagues developed biocompatible Ag–TiO 2 hybrid nanorods (HNRs) with significant ROS production capabilities. 99 AgNPs on the surface of TiO 2 NRs helped to increase the photocatalytic activity by slowing the recombination rate of electron–hole pairs (Fig. 12(e)).…”

One-dimensional nanomaterials for cancer therapy and diagnosis

“…In 2019, Iqbal's group reported Ag decorated TiO 2 hybrid nanorods ( Ag-TiO 2 NPs ), which can be used for 4T1 breast cancer treatment. 58 The TiO 2 NPs have a narrow energy bandgap (3.2 eV) and reduce the recombination rate of electron–hole, resulting in various and large amount of ROS such as hydroxyl (˙OH) and superoxide radicals (O 2 ˙ − ) through photogenerated electron holes by electron transfer reaction under ultraviolet (UV) irradiation. 59 Over 90% cell death was observed when the Ag-TiO 2 NPs (120 μg mL −1 ) were irradiated under UV light at low intensity (5.6 mW cm −2 , 30 min), showing enhanced PDT efficacy of the as-prepared Ag-TiO 2 NPs .…”

Nanomaterial-assisted CRISPR gene-engineering – A hallmark for triple-negative breast cancer therapeutics advancement

“…In recent years, PDT has been proven efficient in various types of breast-related carcinoma. For example, Ag decorated TiO 2 nanorod (200 ​μg ​mL¯ 1 ) was used to generate excessive intracellular ROS under 30 ​min of 5.6 ​mW ​cm¯ 2 UV irradiation, resulting in activation of apoptosis and 90% breast cancer cell killing [ 216 ]. Further, PDT does not produce any ionizing radiations and systemic toxicity, which can alter the biological medium.…”