ROS scavenging of SOD/CAT mimics probed by EPR and reduction of lipid peroxidation in S. cerevisiae and mouse liver, under severe hydroxyl radical stress condition

Menezes, Lucas B.; Segat, Bruna B.; Tolentino, Hugo; Pires, Daniele C.; Mattos, Larissa M. de M.; Hottum, Hyan M.; Pereira, Marcos D.; Latini, Alexandra; Horn, Adolfo; Fernandes, Christiane

doi:10.1016/j.jinorgbio.2022.112062

Cited by 19 publications

(14 citation statements)

References 48 publications

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“…One of the processes responsible for oxidative stress is lipid peroxidation (LPO) [ 25 ]. In the course of this process we distinguish three stages: initiation, propagation, and termination [ 26 , 27 ].…”

Section: Oxidant–antioxidant Balance and Lipid Peroxidationmentioning

confidence: 99%

Links between Vitamin K, Ferroptosis and SARS-CoV-2 Infection

et al. 2023

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Ferroptosis is a recently discovered form of programmed cell death. It is characterized by the accumulation of iron and lipid hydroperoxides in cells. Vitamin K is known to have antioxidant properties and plays a role in reducing oxidative stress, particularly in lipid cell membranes. Vitamin K reduces the level of reactive oxygen species by modulating the expression of antioxidant enzymes. Additionally, vitamin K decreases inflammation and potentially prevents ferroptosis. Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection leading to coronavirus disease 2019 (COVID-19) is associated with oxidant–antioxidant imbalance. Studies have shown that intensified ferroptosis occurs in various tissues and cells affected by COVID-19. Vitamin K supplementation during SARS-CoV-2 infection may have a positive effect on reducing the severity of the disease. Preliminary research suggests that vitamin K may reduce lipid peroxidation and inhibit ferroptosis, potentially contributing to its therapeutic effects in COVID-19 patients. The links between ferroptosis, vitamin K, and SARS-CoV-2 infection require further investigation, particularly in the context of developing potential treatment strategies for COVID-19.

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Section: Oxidant–antioxidant Balance and Lipid Peroxidationmentioning

confidence: 99%

Links between Vitamin K, Ferroptosis and SARS-CoV-2 Infection

et al. 2023

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“…Hence, lipid peroxidation happened in muscle inevitably. Meanwhile, SOD and CAT are the scavenger enzymes of free radical and can reduce the lipid peroxidation degree of animals [ 38 ]. Therefore, significantly higher SOD and CAT activities in the muscle of middle level A .…”

Section: Discussionmentioning

confidence: 99%

Effect of dietary supplementation Ampelopsis grossedentata extract on growth performance and muscle nutrition of Megalobrama hoffmanni by gut bacterial mediation

Yang,

Wang,

et al. 2024

Heliyon

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“…Additionally, the liver and kidneys are the foremost detoxification and metabolic organs, playing a regulatory role in maintaining body health [ 41 ]. In particular, the liver is also the most important organ for the production of various antioxidative enzymes and antioxidants, such as SOD, CAT, GSH, etc., which could spread through the blood to other parts of the body, including the brain [ 42 ]. Therefore, the health status of the body’s organs is very important.…”

Section: Discussionmentioning

confidence: 99%

Protective Effect of Que Zui Tea on d-Galactose-Induced Oxidative Stress Damage in Mice via Regulating SIRT1/Nrf2 Signaling Pathway

Wang,

Zhao

et al. 2024

Molecules

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Que Zui tea (QT) is an important herbal tea in the diet of the ‘Yi’ people, an ethnic group in China, and it has shown significant antioxidant, anti-inflammatory, and hepatoprotective effects in vitro. This study aims to explore the protective effects of the aqueous-ethanol extract (QE) taken from QT against ᴅ-galactose (ᴅ-gal)-induced oxidative stress damage in mice and its potential mechanisms. QE was identified as UHPLC-HRMS/MS for its chemical composition and possible bioactive substances. Thus, QE is rich in phenolic and flavonoid compounds. Twelve compounds were identified, the main components of which were chlorogenic acid, quinic acid, and 6′-O-caffeoylarbutin. Histopathological and biochemical analysis revealed that QE significantly alleviated brain, liver, and kidney damage in ᴅ-gal-treated mice. Moreover, QE remarkably attenuated oxidative stress by activating the Nrf2/HO-1 pathway to increase the expression of antioxidant indexes, including GSH, GSH-Px, CAT, SOD, and T-AOC. In addition, QE administration could inhibit the IL-1β and IL-6 levels, which suppress the inflammatory response. QE could noticeably alleviate apoptosis by inhibiting the expressions of Caspase-3 and Bax proteins in the brains, livers, and kidneys of mice. The anti-apoptosis mechanism may be related to the upregulation of the SIRT1 protein and the downregulation of the p53 protein induced by QE in the brain, liver, and kidney tissues of mice. Molecular docking analysis demonstrated that the main components of QE, 6′-O-caffeoylarbutin, chlorogenic acid, quinic acid, and robustaside A, had good binding ability with Nrf2 and SIRT1 proteins. The present study indicated that QE could alleviate ᴅ-gal-induced brain, liver and kidney damage in mice by inhibiting the oxidative stress and cell apoptosis; additionally, the potential mechanism may be associated with the SIRT1/Nrf2 signaling pathway.

show abstract

ROS scavenging of SOD/CAT mimics probed by EPR and reduction of lipid peroxidation in S. cerevisiae and mouse liver, under severe hydroxyl radical stress condition

Cited by 19 publications

References 48 publications

Links between Vitamin K, Ferroptosis and SARS-CoV-2 Infection

Links between Vitamin K, Ferroptosis and SARS-CoV-2 Infection

Effect of dietary supplementation Ampelopsis grossedentata extract on growth performance and muscle nutrition of Megalobrama hoffmanni by gut bacterial mediation

Protective Effect of Que Zui Tea on d-Galactose-Induced Oxidative Stress Damage in Mice via Regulating SIRT1/Nrf2 Signaling Pathway

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