Rosa davurica Inhibited Allergic Mediators by Regulating Calcium and Histamine Signaling Pathways

Lim, Seojun; Oh, Sarang; Nguyen, Quynh T. N.; Kim, Myeongju; Zheng, Shengdao; Fang, Minzhe; Yi, Tae–Hoo

doi:10.3390/plants12071572

Cited by 3 publications

(3 citation statements)

References 27 publications

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“…Following the harvest, a total of 4 samples, each representing three replicates per experimental plot, were collected for analysis. The method of Oh S et al was used to extract R. davurica exactly as it was [10].…”

Section: Sample Preparationsmentioning

confidence: 99%

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Antioxidant Activity According to the Planting Interval and Collecting Time of Rosa davurica

Zheng,

Kim,

2023

Applied Sciences

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This study aimed to assess functional substances and antioxidant effects with respect to planting intervals and collection timing, with the goal of developing efficient planting methods for the mass harvesting of Rosa davurica and enhancing the availability of the plant’s edible parts in Korea. High-Performance Liquid Chromatography (HPLC) was employed to analyze the ethyl gallate content, a recognized functional component present in R. davurica, while the antioxidant effect was verified using DPPH, ABTS, and SOD assays. The findings revealed an increased yield of buds and leaves in R. davurica when the planting interval was reduced to 120 × 50 cm compared to the conventional 120 × 100 cm spacing. Specifically, the content of ethyl gallate remained consistent across different collection periods, and this result was associated with the varying planting intervals. While there were no significant changes in total polyphenol and flavonoid content, the collection from September demonstrated higher levels. Furthermore, the study established that leaf antioxidant activity, determined through IC50 values of DPPH and ABTS, surpassed that of the buds, with no significant difference in SOD activity being observed. Overall, no substantial differences were observed in the content of functional components between the buds and leaves of R. davurica, regardless of planting interval and collection timing. These results contribute valuable insights for optimizing planting methods for the large-scale collection of R. davurica leaves.

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Section: Sample Preparationsmentioning

confidence: 99%

“…A recent study revealed that a 30% ethanol extract from R. davurica inhibited UVB-induced photoaging [9]. Also, a similar extract inhibited the release of cytokines and histamine in activated DNP-IgE mast cells, thereby exhibiting potential in managing allergic diseases [10].…”

Section: Introductionmentioning

confidence: 99%

Antioxidant Activity According to the Planting Interval and Collecting Time of Rosa davurica

Zheng,

Kim,

2023

Applied Sciences

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“…R. davurica fruit (RDP-F) is generally used as a traditional medicine in many countries such as China, Korea, and Japan [ 15 , 16 , 17 ]; however, only in China is it widely used in food. The health-promoting effects of R. davurica , such as its antioxidant, anti-inflammatory, antiviral, and hypoglycemic activities, are well-established [ 17 , 18 , 19 , 20 ]. R. davurica fruit (RDP-F) is also commonly consumed as a beverage and health food in China [ 21 ].…”

Section: Introductionmentioning

confidence: 99%

UPLC-ESI-MS/MS-Based Analysis of Various Edible Rosa Fruits Concerning Secondary Metabolites and Evaluation of Their Antioxidant Activities

Ni,

Chen,

et al. 2024

Foods

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The genus Rosa is globally popular with well-established applications since it has a high edible and medicinal value. However, relatively limited research has been conducted on the composition and quality of wild Rosa fruits. The present study aimed to compare the properties and chemical components of five wild edible Rosa fruits, Rosa roxburghii, Rosa sterilis, Rosa laevigata, Rosa davurica, and Rosa sericea. The UPLC-ESI-MS/MS approach identified the key metabolites among the five Rosa fruits as flavonoids, phenolic acids, and organic acids. The main differential metabolites among the five fruits are flavonoids (22.29–45.13%), phenolic acids (17–22.27%), and terpenoids (7.7–24%), respectively. In total, 125 compounds served as potential markers for the five Rosa species. Differential metabolic pathways of five Rosa fruits were analyzed using the KEGG approach. Rosa laevigata fruits showed the highest total polysaccharide (TPS) content of 64.48 g/100 g. All the five Rosa extracts effectively decreased the levels of malondialdehyde while increasing the activities of superoxide dismutase and glutathione peroxidase in the H2O2-induced HaCaT cell model, demonstrating high potential for antioxidant development. Our findings suggest that the five studied Rosa fruits exhibit biological activity and edible value worth further exploration.

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Anti-Allergic and Anti-Inflammatory Signaling Mechanisms of Natural Compounds/Extracts in In Vitro System of RBL-2H3 Cell: A Systematic Review

Rana,

Bansode,

Williams

2024

Cells

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Various extracts are tested for anti-allergic or anti-inflammatory properties on in vitro models. RBL-2H3 cells are widely used in allergic or immunological studies. FCεRI and its downstream signaling cascades, such as MAPK, NF-κB, and JAK/STAT signaling pathways, are important allergic or inflammatory signaling mechanisms in mast and basophil cells. This systematic review aims to study common signaling pathways of the anti-allergic or anti-inflammatory compounds on RBL-2H3 cells. We selected the relevant research articles published after 2015 from the PubMed, Scopus, Science Direct and Web of Science databases. The risk of bias of the studies was assessed based on the modified CONSORT checklist for in vitro studies. The cell lines, treatments, assay, primary findings, and signaling pathways on RBL-2H3 cells were extracted to synthesize the results. Thirty-eight articles were included, and FCεRI and its downstream pathways, such as Lyn, Sky, PLCγ, and MAPK, were commonly studied. Moreover, the JAK/STAT pathway was a potential signaling mechanism in RBL-2H3 cells. However, the findings based on RBL-2H3 cells needed to be tested along with human mast cells to confirm its relevance to human health. In conclusion, a single plant extract may act as an anti-inflammatory reagent in RBL-2H3 cells via multiple signaling pathways besides the MAPK signaling pathway.

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Rosa davurica Inhibited Allergic Mediators by Regulating Calcium and Histamine Signaling Pathways

Cited by 3 publications

References 27 publications

Antioxidant Activity According to the Planting Interval and Collecting Time of Rosa davurica

Antioxidant Activity According to the Planting Interval and Collecting Time of Rosa davurica

UPLC-ESI-MS/MS-Based Analysis of Various Edible Rosa Fruits Concerning Secondary Metabolites and Evaluation of Their Antioxidant Activities

Anti-Allergic and Anti-Inflammatory Signaling Mechanisms of Natural Compounds/Extracts in In Vitro System of RBL-2H3 Cell: A Systematic Review

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