2016
DOI: 10.4081/dr.2016.6387
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Rosacea: a clinical review

Abstract: Rosacea is a field within dermatology with new insight within immunological research and new treatment-algorithm. Patient education on rosacea and appropriate treatments is an important aspect in helping patients succeed with therapy. Treatment should be tailored to each individual patient, taking into account: symptoms, trigger factors, patients’ wishes, most bothersome symptoms, psychological aspect, individual needs. A combination of clinical therapies to treat different symptoms concomitantly may offer the… Show more

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Cited by 35 publications
(27 citation statements)
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“…Rosacea is a chronic inflammatory skin disease that mostly affects middle-aged blonde women with light skin and blue eye, although it can be seen in any person [5,9]. Rosacea has multi-factorial pathology including vasoactive and neurocutaneous components as well as innate and acquired immunity.…”
Section: Discussionmentioning
confidence: 99%
See 1 more Smart Citation
“…Rosacea is a chronic inflammatory skin disease that mostly affects middle-aged blonde women with light skin and blue eye, although it can be seen in any person [5,9]. Rosacea has multi-factorial pathology including vasoactive and neurocutaneous components as well as innate and acquired immunity.…”
Section: Discussionmentioning
confidence: 99%
“…The expression of various genes that play a role in the innate and acquired immune systems has been shown to increase in patients with rosacea. Microorganisms such as Demodex folliculorum, Staphylococcus epidermidis, ultraviolet (UV) rays, and transient receptor potential family are among the blamed factors for the etiology [1,2,5].…”
Section: Introductionmentioning
confidence: 99%
“…[35][36][37][38][39][40][41][42][43] The large body of evidence supporting an inflammatory pathogenesis of rosacea that is not triggered by a bacterial etiology has led globally to rosacea management recommendations supporting that avoidance of an antibiotic effect whenever possible is favorable in order to reduce the emergence of antibiotic-resistant bacteria. [44][45][46][47] In their rosacea medical management guidelines, the American Acne & Rosacea Society stated the following: "The lack of data supporting a bacterial component definitively related to the pathogenesis of rosacea suggests overall that medical therapies which are anti-inflammatory in nature are best considered for initial treatment of rosacea, especially the inflammatory (papulopustular) subtype, with oral antibiotic agents used in cases that are poorly responsive to a reasonable trial of topical therapy and/or oral anti-inflammatory therapy". 44 To achieve this, available topical agents with demonstrated anti-inflammatory effects, efficacy, and safety in rosacea would include azelaic acid and ivermectin.…”
Section: -29 (3) Management Of Rosacea Does Not Require An Antibiotmentioning
confidence: 99%
“…44 To achieve this, available topical agents with demonstrated anti-inflammatory effects, efficacy, and safety in rosacea would include azelaic acid and ivermectin. 41,42,[44][45][46][47][48][49] Sub-antibiotic dose doxycycline (such as the modified-release 40 mg capsule once daily or 20 mg immediate-release tablet twice daily) provides anti-inflammatory effects with efficacy and favorable safety for rosacea, without inducing antibiotic selection pressure. 40,[44][45][46][47]50 …”
Section: -29 (3) Management Of Rosacea Does Not Require An Antibiotmentioning
confidence: 99%
“…Clinical Caveats Related to Antibiotic Use in Dermatology3,[11][12][13][14]16,17,19,20,26,[44][45][46][47][48][49][50][51][52][53][54][55][56][58][59][60] …”
mentioning
confidence: 99%