Rosacea‐like demodicosis (but not primary demodicosis) and papulopustular rosacea may be two phenotypes of the same disease – a microbioma, therapeutic and diagnostic tools perspective

Tatu, Alin Laurențiu; Clătici, Victor Gabriel; Nwabudike, Lawrence Chukwudi

doi:10.1111/jdv.15166

Cited by 27 publications

(27 citation statements)

References 9 publications

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“…It is common knowledge that hospitals are threatened by nosocomial infections due to these killer microorganisms [11]. The adverse effects of different synthetic drugs are wellknown when they are prescribed for different diseases or comorbidities [12][13][14][15][16][17][18][19][20][21][22][23][24][25][26][27][28][29].The usage of natural extracts or plant derivates is desirable for their efficacy without major adverse reactions even on normal microbioma, or if needed after the informed consent even in pregnancy [30][31][32][33][34][35][36][37][38][39][40][41][42].It is possible to use these natural products under various pharmaceutical forms, some of them even retard forms, in view of reducing nosocomial infections in hospitals.…”

Section: Discussionmentioning

confidence: 99%

Pharmaceutical Forms with Basil and Propolis to the Benefit of the Oral Cavity. Formulation, preparation and microbiological analysis

Buzia¹,

Mardare²,

Dragomir³

et al. 2019

Rev. Chim.

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The present paper aims at formulating, preparing, following the antibacterial activity of pharmaceutical forms with oral cavity applicability. Two pharmaceutical forms were prepared, a tincture and a toothpaste based on basil and propolis, being subsequently compared to the mix of basil and propolis tinctures that are commercially available; each pharmaceutical form was analyzed organoleptically and microbiologically. As a result of the measurements the conclusion was drawn that the tinctures prepared, the propolis tincture and the basil tincture show a strong sensitivity Staphylococcus aureus, Pseudomonas aeruginosa; and Enterococcus hormaechei.Candida albicans reacted more strongly to the propolis tincture, and less to the basil tincture. The scientific novelty of the paper consists in the formulation and determination of the antimicrobial activity of the toothpaste prepared in the laboratory of the Pharmacy Faculty of Galati. The results obtained were favorable on microorganisms acting on the oral cavity, i.e. gram positive germs, gram negative germs and fungi. Keyworlds:basil(Ocimum basilicum)propolis, lemon basil, tincture

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Section: Discussionmentioning

confidence: 99%

Pharmaceutical Forms with Basil and Propolis to the Benefit of the Oral Cavity. Formulation, preparation and microbiological analysis

Buzia¹,

Mardare²,

Dragomir³

et al. 2019

Rev. Chim.

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“…Rosacea and demodicosis are common dermatoses, but classification and diagnostic criteria are still controversial . The National Rosacea Society expert committee defines rosacea as a central‐face distribution of at least one of four primary features: flushing, persistent erythema, papules and pustules, and telangiectasia.…”

mentioning

confidence: 99%

“…Rosacea and demodicosis are common dermatoses, but classification and diagnostic criteria are still controversial. [1][2][3][4][5][6][7] The National Rosacea Society expert committee defines rosacea as a central-face distribution of at least one of four primary features: flushing, persistent erythema, papules and pustules, and telangiectasia. The committee identified four subtypes: erythematotelangiectatic rosacea (ETR), papulopustular rosacea (PPR), phymatous rosacea and ocular rosacea.…”

mentioning

confidence: 99%

“…Demodicosis is, by definition, caused by Demodex mites, and can have various clinical manifestations: pityriasis folliculorum, rosacea-like demodicosis, follicular eczematids, Demodex folliculitis, demodectic prurigo, isolated inflammatory papules, demodectic postinflammatory pigmentation and ocular demodicosis. [3][4][5][6][7][8][9][10][11][12][13][14][15][16] Demodex folliculorum and Demodex brevis are spindle-shaped transparent mites that live exclusively in human pilosebaceous follicles. 17 A newborn child has no Demodex mites on his or her skin, and the mites are acquired by direct contact with the skin of other humans.…”

mentioning

confidence: 99%

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Erythematotelangiectatic rosacea may be associated with a subclinical stage of demodicosis: a case–control study

Forton¹,

Maertelaer²

2019

Br J Dermatol

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Summary Background Facial densities of Demodex mites have been observed to be greater in patients with demodicosis and papulopustular rosacea than in healthy control patients. In patients with erythematotelangiectatic rosacea (ETR), this density has been observed to be similar to or greater than that of healthy controls. Erythema and telangiectasia, characteristics of ETR, are often observed among patients with pityriasis folliculorum, a discreet demodicosis, suggesting a possible link between these conditions. Objectives To compare the facial Demodex densities of patients with clinical ETR and patients with healthy skin, demodicosis, rosacea with papulopustules, and other facial dermatoses. Methods In this retrospective study, we recorded Demodex densities measured using two consecutive standardized skin surface biopsies (SSSB1 and SSSB2) in 23 patients with ETR, 20 healthy control patients, 590 patients with demodicosis, 254 with rosacea with papulopustules and 180 with other facial dermatoses. Results Patients with ETR had higher Demodex densities (D cm−2) than did the healthy controls (mean ± SEM; SSSB1: 15·7 ± 6·3 vs. 1·8 ± 1·1 D cm−2, P = 0·042; SSSB2: 38·0 ± 13·7 vs. 5·1 ± 2·1 D cm−2, P = 0·026) and patients with other dermatoses (SSSB1: 0·4 ± 0·1 D cm−2, P = 0·004; SSSB2: 1·3 ± 0·3 D cm−2, P = 0·004), but lower densities than patients with demodicosis (SSSB1: 82·7 ± 4·2 D cm−2, P = 0·008; SSSB2: 172·2 ± 7·7 D cm−2, P = 0·001) or rosacea with papulopustules (SSSB1: 86·6 ± 7·3 D cm−2, P = 0·027; SSSB2: 197·0 ± 12·1 D cm−2, P = 0·002). Conclusions ETR may be associated with nonvisible Demodex proliferation, possibly corresponding to a subclinical stage of demodicosis. Dermatologists should be aware of this potential association and look for subclinical demodicosis in patients with ETR, so that topical acaricidal treatment can be offered if Demodex density is high.

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“…In the case of atopic dermatitis, studies have suggested a decrease in the normal flora, which can correlate with acute stages of the disease. A study has emphasized that after anti-inflammatory and emollients treatments normal genus like Streptococcus, Propionibacterium and Corynebacterium increased in the skin [23][24][25][26][27][28][29][30]. We should be aware of the cutaneous side effects of topical steroids even on skin normal microbioma [31][32][33].…”

Section: Does Treatment Affect the Cutaneous Microbiome?mentioning

confidence: 99%

A short review about cutaneous microbiome

Tatu

Radaschin

2018

Ann_UGAL_Math_Phys_Mec

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Since 2000, when Nobel prize winner, Joshua Lederberg defined the term "cutaneous microbiome" much attention has been drawn to clarifying the role of microorganisms in maintaining homeostasis. This article aims to outline the several implications of the cutaneous microbiome related to dermatology practice. The skin microbiome represents the community of commensal, symbiotic, and pathogenic microorganisms that colonizes the skin. Prior research on healthy volunteers indicate the presence of four major bacterial species: Actinobacteria, Firmicutes, Proteobacteria and Bacterioides. Previous studies have proved that the skin microbiome influences the innate and the adaptive immune responses. This theory may be the key in establishing the etiopathogenesis of chronic inflammatory diseases, such as atopic dermatitis, psoriasis, acne vulgaris and rosacea. The diversity of microorganisms harbored on the healthy skin surface is different from one body area to another, according to pH, temperature, age, hygiene. Any imbalance in the physiological features will have consequences on the commensal flora. A decrease of the commensal microorganisms will lead to higher levels of pathogens, exposing the skin barrier, leading to infection and chronic inflammation as seen in atopic dermatitis. New studies are focusing on how treatments affect the cutaneous microbiome. Different kinds of topical treatments can interfere with the normal flora, which can cause soreness and slow healing. In psoriasis, it has been suggested that the microbial diversity is limited by the production of antimicrobial peptides, which is relieved by therapy. Future research in this field can highlight new therapies in dermatology, provide answers concerning etiopathogeneses and better understanding of cutaneous inflammatory diseases.

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Rosacea‐like demodicosis (but not primary demodicosis) and papulopustular rosacea may be two phenotypes of the same disease – a microbioma, therapeutic and diagnostic tools perspective

Abstract: Linked article: This article is commentary on by F. Forton et al., pp. e47–e48 in this issue. To view this article visit https://doi.org/10.1111/jdv.15162

Cited by 27 publications

References 9 publications

Pharmaceutical Forms with Basil and Propolis to the Benefit of the Oral Cavity. Formulation, preparation and microbiological analysis

Pharmaceutical Forms with Basil and Propolis to the Benefit of the Oral Cavity. Formulation, preparation and microbiological analysis

Erythematotelangiectatic rosacea may be associated with a subclinical stage of demodicosis: a case–control study

A short review about cutaneous microbiome

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