Rosacea

Bonamigo, Renan Rangel; Bertolini, Wagner; Dornelles, Sérgio Ivan Torres

doi:10.1007/978-3-319-33919-1_22

Cited by 4 publications

(5 citation statements)

References 75 publications

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“…Зростаюча кількість клініцистів без вищої медичної освіти (NPC) відкриває потенціал для розширення дерматологічного доступу, але може вплинути на якість медичної допомоги. [23].…”

Section: обговоренняunclassified

Dermatologic and ophthalmologic collaboration in the management of skin manifestations of ocular rosacea

Малачкова,

Жмудь,

Кривецька

et al. 2023

Oftalmol Zh

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This case is presented to (1) improve the efficacy of the identification and differential diagnosis and to avoid mistreatment of the skin manifestations of ocular rosacea exhibiting a clinical appearance of those of other disorders and (2) explore opportunities for building dermatologic and ophthalmologic collaboration in the management of patients with ocular symptoms of rosacea. A 33-year-old female patient was diagnosed with acne vulgaris and seborrhea oleosa by a dermatologist. She received a secondary diagnosis of adrenal hyperandrogenism, iron deficiency anemia and selenium and iodine deficiency. The patient underwent facial skin peeling and was prescribed dermatological treatment. Thereafter, she presented to an ophthalmologist and complained of gritty eyes and blurred vision which she had never before experienced. Ocular manifestations included macerated skin of the eyelid angles, palpebral edema, crusts at the eyelid margin and eyelid telangiectasia. The patient was diagnosed with ocular rosacea, dry eye and keratoconjunctivitis sicca, and obtained the prescribed ophthalmological treatment which resulted in an improvement in her ocular symptoms. Therefore, ocular rosacea should be treated through the cooperative efforts of dermatologists and ophthalmologists based on the constellation of clinical findings and symptoms in a particular case.

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Section: обговоренняunclassified

Dermatologic and ophthalmologic collaboration in the management of skin manifestations of ocular rosacea

Малачкова,

Жмудь,

Кривецька

et al. 2023

Oftalmol Zh

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“…Topical treatments include metronidazole, azelaic acid, ivermectin, and brimonidine. Oral antibiotics like doxycycline are commonly used for their anti-inflammatory effects ( 17 ). Macrophages are essential immune cells that protect against pathogens in the skin and throughout the body ( 18 ).…”

Section: Introductionmentioning

confidence: 99%

The role of macrophages in rosacea: implications for targeted therapies

Liu,

Zhou,

Chu

et al. 2023

Front. Immunol.

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IntroductionRosacea, a widespread chronic skin condition, may be influenced by macrophages, key immune cells in the skin, although their exact role is not yet fully understood. This review delves into the function of macrophages, their potential contribution to rosacea pathogenesis, current treatments, and promising macrophage-targeted therapies. It concludes by identifying knowledge gaps and potential areas for future rosacea research.MethodLeveraging systematic and narrative literature review techniques, we conducted a comprehensive search of databases such as PubMed, Embase, and Web of Science. Utilizing keywords like “rosacea” and “macrophages”, we targeted English articles from the last 5 years (2018-2023). We manually checked reference lists of relevant articles for additional studies. We included only articles emphasizing macrophages’ role in rosacea and/or the development of related therapies and published within the specified timeframe.ResultsThe systematic search of electronic databases yielded a total of 4,263 articles. After applying the inclusion and exclusion criteria, 156 articles were selected for inclusion in this review. These articles included original research studies, review articles, and clinical trials that focused on the role of macrophages in rosacea and/or the development of macrophage-targeted therapies for the disease. The selected articles provided a comprehensive and up-to-date overview of the current state of research on macrophages in rosacea, including their function in the skin, the potential mechanisms through which they may contribute to rosacea pathogenesis, and the current treatments and therapies available for the disease. Additionally, the articles identified gaps in knowledge regarding the role of macrophages in rosacea and suggested potential areas for future research.ConclusionThis literature review emphasizes the important role that macrophages, vital immune cells in the skin, may play in the pathogenesis of rosacea, a common chronic inflammatory skin disorder. The selected studies suggest potential mechanisms by which these cells might contribute to rosacea progression, although these mechanisms are not yet fully understood. The studies also spotlight current rosacea treatments and illuminate the promising potential of new macrophage-focused therapies. Despite these insights, significant gaps persist in our understanding of the precise role of macrophages in rosacea. Future research in this area could provide further insights into the pathogenesis of rosacea and contribute to the development of more effective, targeted therapeutic strategies.

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“… 13 , 14 , 15 Chang et al identified that genes associated with rs763035 are expressed in rosacea skin samples and identified that three class II alleles of the major histocompatibility complex (MHC), including HLA-DRB1, HLA-DQB1, and HLA-DQA1, are involved. 16 , 17 , 18 …”

Section: Introductionmentioning

confidence: 99%

“…This steroid hormone probably influences the pathway associated with TLR-2, KLK-5, and LL-37, altering the immune system. 17 , 23 , 24 …”

Section: Introductionmentioning

confidence: 99%

“…In neurovascular dysregulation, vanilloid and ankyrin receptors – present in neuronal tissues, in the endothelium, and in keratinocytes – can release important neuropeptides in the characteristic flushing of rosacea; they can be triggered by heat, cold, alcohol, spicy foods, and chemicals. 2 , 7 , 8 , 11 , 17 , 30 , 31 , 32 …”

Section: Introductionmentioning

confidence: 99%

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Consensus on the therapeutic management of rosacea – Brazilian Society of Dermatology

Oliveira

Almeida

Bonamigo

et al. 2020

Anais Brasileiros de Dermatologia

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Background Rosacea is a chronic inflammatory disease of the skin, relatively more frequent in women over 30 with a low phototype and proven genetic predisposition. Although its etiology is unknown and possibly multifactorial, the immunological abnormality, associated with neurovascular dysregulation and triggering factors, are important elements in its pathophysiology, which lead to the main changes of inflammation, vasodilation, and angiogenesis that are responsible for the clinical manifestations. Despite the lack of cure, numerous therapeutic options are available for the different clinical presentations of the disease, with satisfactory responses. Objective To reach a consensus, with recommendations from experts, on the therapeutic management of rosacea suitable to the Brazilian setting. Methods The study was conducted by five specialized dermatologists from university centers, representatives of the different Brazilian regions, with experience in rosacea, who were appointed by the Brazilian Society of Dermatology. Based on the adapted DELPHI methodology, the experts contributed through an updated bibliographic review of the scientific evidence, combined with personal experiences. Results The group of experts reached a consensus on the relevant aspects in the therapeutic management of rosacea, providing information on epidemiology, pathophysiology, triggering factors, clinical condition, classification, quality of life, and comorbidities. Consensus was defined as approval by at least 90% of the panel. Conclusion Despite the impossibility of cure, there are several therapeutic alternatives specific to each patient that provide excellent results, with chances of total improvement and long periods of remission, promoting a positive impact on quality of life. This consensus provides detailed guidance for clinical practice and therapeutic decisions in rosacea.

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Rosacea

Cited by 4 publications

References 75 publications

Dermatologic and ophthalmologic collaboration in the management of skin manifestations of ocular rosacea

Dermatologic and ophthalmologic collaboration in the management of skin manifestations of ocular rosacea

The role of macrophages in rosacea: implications for targeted therapies

Consensus on the therapeutic management of rosacea – Brazilian Society of Dermatology

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