Rosacea Pathogenesis

Ahn, Christine S.; Huang, William W.

doi:10.1016/j.det.2017.11.001

Cited by 125 publications

(127 citation statements)

References 38 publications

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“…LL‐37 is a key contributor with kallikrein 5 (KLK5) to immune dysregulation in the skin of patients with rosacea. There are increased levels of MMP‐9 in the skin of patients with rosacea, which may lead to increased KLK5 and LL‐37 levels 30,31 . Thus, matrix metalloproteinase‐9 (MMP‐9) is can be another factor of the possible common etiology.…”

Section: Discussionmentioning

confidence: 99%

Demodex positive discoid lupus erythematosus: Is it a separate entity or an overlap syndrome?

Dursun

Durmaz

Oltulu

et al. 2020

Dermatologic Therapy

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Discoid lupus erythematosus (DLE) is a chronic inflammatory erythematous skin disease that can be triggered by several factors. Rosacea is another skin disease that causes facial redness and tenderness. Demodex mites have been reported in rosacea and DLE patients commonly in the literature. These two diseases can be seen concomitant, mimic each other clinically and share common possible etiologic factors. To assess demodex mite infestation in both clinical and histopathological findings in DLE patients. We retrospectively evaluated the files of 42 patients with DLE who had been diagnosed DLE based on clinical and histopathological findings between August 2018 and August 2019. Demodex positivity was detected 50% of patients (n = 21). Neutrophile percentages in the dermal and perivascular area were higher in the demodex positive patients (4.43%) than in the Demodex negative patients (2.19%). The intensity of demodex mites correlated positively with dermal neutrophile percentages. ANA was negative in 29 patients (69%) and positive in 13 patients (31%). Anti‐dsDNA was negative in serology and follicular plugging was positive in histopathology in all 42 patients (100%). This was a retrospective study. DLE and rosacea share common features in etiopathogenesis and clinical presentation. Inflammation and exacerbations caused by the demodex mites may increase the clinical severity of DLE. Although the position of demodex mites in DLE etiopathogenesis is not known exactly, the presence of high demodex in DLE patients has been determined. Standard skin surface biopsy can be a routine procedure for the evaluation of DLE patients in daily clinical practice.

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Section: Discussionmentioning

confidence: 99%

Demodex positive discoid lupus erythematosus: Is it a separate entity or an overlap syndrome?

Dursun

Durmaz

Oltulu

et al. 2020

Dermatologic Therapy

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“…It is not exactly known whether this altered flora is a consequence of rosacea or it is a trigger for rosacea. Additionally, H.pylori, UV‐A, and UV‐B can also be considered among the other triggering factors …”

Section: Discussionmentioning

confidence: 99%

Increased frequency of Demodex blepharitis in rosacea and facial demodicosis patients

Saraç

Çankaya

Ozcan

et al. 2019

J of Cosmetic Dermatology

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Background Rosacea is an inflammatory disease with 50% of ocular involvement rate. Primary demodicosis is an eruption caused by Demodex mites, and there is no data about the rate of ocular involvement in primary demodicosis. Aims In this cross‐sectional study, it is aimed to reveal the frequency of Demodex blepharitis in rosacea and primary demodicosis patients. Methods In total, 58 rosacea, 33 primary demodicosis patients, and 31 healthy volunteers were included in the study. Four samples were obtained from eyelashes with a forceps and from facial skin by standardized skin surface biopsy. A positive result is described as detecting at least one Demodex mite on an eyelash or at five mites in the face. The patients were also examined by an ophthalmologist in terms of ocular involvement. Results Both rosacea and primary demodicosis patients had significantly more complaints like burning and stinging in the eyes compared to the control patients (P = .001). Primary demodicosis and papulopustular rosacea patients had the highest numbers of eyelash mites, respectively, and significantly a higher rate of blepharitis than the control group. Conclusion As a result, the Demodex count was significantly higher in the primary demodicosis and rosacea patients than the control group. We think that every Demodex‐positive patients should be evaluated for also eyelash mites to prevent a possible chronic blepharitis.

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“…[ 1 – 3 ] These subtypes present with symptoms such as facial erythema, telangiectases, papules, and pustules. [ 22 – 24 ] And one of the underlying mechanisms of acupuncture is cutaneous neurogenic inflammation changes at acupoints. [ 25 – 27 ] Thus, these studies suggested that acupuncture could be possibly used to treat the papulopustular and ocular rosacea.…”

Section: Discussionmentioning

confidence: 99%

Treatment of Rosacea using acupuncture for improving the local skin microcirculation

et al. 2018

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Rationale:Rosacea is an irritating disease that affects patients’ health and life quality. The current treatments for rosacea have limited efficacy and are generally not satisfying most patients. This report presents a patient diagnosed with rosacea who was treated with acupuncture to a satisfactory effect. Laser Doppler was used to measure the local blood perfusion of the nose before, during, and after acupuncture treatment. The Dermatology Life Quality Index (DLQI) was used to measure the impact of rosacea on the quality of the patient's life.Patient concerns:A 52-year-old woman had been diagnosed with rosacea 18 months before this study. She had tried medical treatments in other hospitals with metronidazole cream, antifungal drugs, and steroidal ointments, but the effect was poor and limited.Diagnoses:In this study, the diagnosis of rosacea (stage I, subtype Erythematotelangiectatic) was made by a dermatologist according to physical examination).Interventions:The patient's treatment included a half-hour of acupuncture 3 times per week.Outcomes:The patient experienced significant improvements in the region around the nose after 3 sessions of acupuncture treatment within the first week and reported that there was no relapse for 6 months after acupuncture treatment. The perfusion of blood flow was redistributed during and after acupuncture treatment according to laser Doppler measurements. The patient's DLQI score substantially improved. The patient was generally satisfied with the acupuncture treatment.Lessons:The results suggested that acupuncture might be an alternative therapy for facial localized rosacea. As well, acupuncture may be effective in treating rosacea through redistributing micro-circulation of blood at the localized area of effect. The overall costs of the rosacea treatment may be reduced, provided that this therapy is demonstrated to be effective in future controlled studies.

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Rosacea Pathogenesis

Cited by 125 publications

References 38 publications

Demodex positive discoid lupus erythematosus: Is it a separate entity or an overlap syndrome?

Demodex positive discoid lupus erythematosus: Is it a separate entity or an overlap syndrome?

Increased frequency of Demodex blepharitis in rosacea and facial demodicosis patients

Treatment of Rosacea using acupuncture for improving the local skin microcirculation

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