Rosacée : nouveautés pour une meilleure prise en charge

Cribier, B.

doi:10.1016/j.annder.2017.06.010

Cited by 10 publications

(5 citation statements)

References 68 publications

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“…Rosacea is a common facial dermatosis with a prevalence of up to 10% if all forms are included [1][2][3][4]. Pure vascular rosacea is the most common form, about four times more frequent than rosacea with papulopustules [1].…”

Section: Rosacea: Definitionsmentioning

confidence: 99%

“…Rosacea is currently considered by most authors as a disease of the immune system, an inflammatory process including innate and then adaptive immune responses, which gets out of control resulting in vascular, inflammatory, and hypertrophic symptoms [2,5,[14][15][16][17][18][19][20][21][22]. Genetic (46%) and environmental (54%) influences have recently been demonstrated in a study on twins [23], and many associated co-morbidities have been highlighted [24].…”

Section: Rosacea: An Inflammatory Continuummentioning

confidence: 99%

“…Indeed, ivermectin was approved by the US Food and Drug Administration and the European Medicines Agency in 2014-2015 as a topical anti-inflammatory treatment for PPR as a 1% once daily application [225]. Ivermectin quickly became established, together with azelaic acid, as a first-line treatment for PPR in mild rosacea [2,183,184,223,[226][227][228][229], and combined with orally administered doxycycline in moderate to severe rosacea [173,230,231]. However, its efficacy may, at least in part, be explained by its other important property: acaricidal effects against the Demodex mite [172,173,225,228,230,[232][233][234][235][236].…”

Section: More Superficial and Smallermentioning

confidence: 99%

“…Topical vasoconstrictors, such as α-blockers (brimonidine, oxymetazoline) [ 183 , 184 ], are used to decrease vasodilation of the dermal capillaries for a limited time, and act mainly on erythema but not on telangiectasia [ 2 ]. They are mainly recommended after light therapy, when this is not completely successful [ 185 ].…”

Section: Current Treatments For Vascular Symptoms Of Rosacea: Acaricimentioning

confidence: 99%

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The Pathogenic Role of Demodex Mites in Rosacea: A Potential Therapeutic Target Already in Erythematotelangiectatic Rosacea?

Forton¹

2020

Dermatol Ther (Heidelb)

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Rosacea is an inflammatory continuum, with all characteristics being already present from the onset of the disease, even if not clinically visible. Demodex proliferation also appears to be a continuum process in rosacea, and high Demodex density is beginning to be accepted as an important trigger of the inflammatory cascade and as a marker of rosacea: moreover, papulopustules of rosacea can be treated using acaricides. Immunological studies are providing new hypotheses according to which Demodex may induce tolerogenic dendritic cells and collaborate with VEGF to induce T cell exhaustion favoring its own proliferation. This proliferation may not be clinically visible initially. The interactions among VEGF, Demodex, and immunity need to be explored, and the nosology of rosacea definitions adapted accordingly. The effectiveness of treating any patient who only has visible vascular symptoms with an acaricidal cream needs to be confirmed in prospective controlled clinical trials with long-term follow-up, but it is already important to detect patients with pityriasis folliculorum among those with only vascular symptoms of rosacea in order to treat at least these patients with an acaricidal cream. DIGITAL FEATURES This article is published with digital features to facilitate understanding of the article. You can access the digital features on the article's associated Figshare page. To view digital features for this article go to

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Section: Rosacea: Definitionsmentioning

confidence: 99%

Section: Rosacea: An Inflammatory Continuummentioning

confidence: 99%

Section: More Superficial and Smallermentioning

confidence: 99%

Section: Current Treatments For Vascular Symptoms Of Rosacea: Acaricimentioning

confidence: 99%

See 2 more Smart Citations

The Pathogenic Role of Demodex Mites in Rosacea: A Potential Therapeutic Target Already in Erythematotelangiectatic Rosacea?

Forton¹

2020

Dermatol Ther (Heidelb)

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“…45 Other researchers showed various factors including vascularity (vascular growth factors, vasodilatation), immune dysregulation, genetic predisposition, inflammation, neurovascular dysregulation (neuropathic pain, hypersensitivity), microorganisms (like Demodex), infections and environmental factors. [46][47][48] Demodex can be involved in the pathological process of rosacea by triggering inflammation or stimulating certain immune responses, mechanical obstruction of the follicles, or acting as a carrier for microorganisms. 44,49 It was found that bacteria isolated from a Demodex mite have the potential to initiate an immune reaction in patients with papulopustular rosacea (PPR) or ocular rosacea.…”

Section: Demodex and Facial Dermatosesmentioning

confidence: 99%