Rosai Dorfman Disease —A rare case of cervical lymphadenopathy

Amiji, Insiyah; Mohammed, Ummulkheir; Salum, Hajaj; Karugaba, Emilia; Mkeni, Luka; Mumburi, Livin; Msafiri, Anna; Massawe, Higgins

doi:10.1002/ccr3.3255

Cited by 7 publications

(11 citation statements)

References 7 publications

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“…The typical symptoms include painless enlarged bilateral cervical lymph nodes with fever, neutrophil elevation, elevated erythrocyte sedimentation rate, hyperglobulinemia, and other clinical symptoms [10]. However, our patient did not exhibit any symptoms, and the lesion was detected on a chest CT scan performed during a routine health checkup.…”

Section: Discussionmentioning

confidence: 60%

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Rosai-Dorfman Disease Manifesting as a Solitary Mass With Fat in the Thymus

Liu,

Liu

et al. 2023

Preprint

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Background Sinus histiocytosis with massive lymphadenopathy, also known as Rosai-Dorfman disease, is a rare, self-limiting disease predominantly affects children and young adults. Moreover, the disease is characterized by painless bilateral cervical lymphadenopathy in 95% of the patients. However, few reports are available on the Rosai-Dorfman disease of the thymus. Case presentation: We report a rare case of thymic Rosai-Dorfman disease detected using computed tomography. During a medical examination, a 50-year-old man underwent a chest computed tomography scan, which revealed an anterior mediastinal single mass with fat in the thymus. A thymectomy was performed to completely remove the tumor using a thoracoscopic technique due to a clinical suspicion of thymoma. Furthermore, Rosai-Dorfman disease was confirmed using histological and immunohistochemical analyses. Conclusions To the best of our knowledge, this is the sixth case of thymus-affecting solitary Rosai-Dorfman disease with histological and immunohistochemical evidence. Fat in the thymus, as was present in this case, has never been described in Rosai-Dorfman disease previously. Our results highlight the challenge of diagnosing this uncommon tumor before surgery, and more cases need to be reported to help with the preoperative diagnosis of such a rare tumor.

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Section: Discussionmentioning

confidence: 60%

“…Some studies have suggested that immunological dysregulation or infections with human herpes virus (HHV)-6, HHV-8, parvovirus B19, and Klebsiella are suspected causes. However, the evidence remains inconclusive [10].…”

Section: Discussionmentioning

confidence: 99%

Rosai-Dorfman Disease Manifesting as a Solitary Mass With Fat in the Thymus

Liu,

Liu

et al. 2023

Preprint

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“…The histiocytes will be positive for immunohistochemical stains S100 and part of CD68 and are typically negative for CD1a. Laboratory ndings in RDD include leukocytosis, neutrophilia, normocytic anemia, thrombocytosis, an elevated C-RP, ESR, ferritin levels and hypergammaglobulinemia [12]. However, these lab ndings are unspeci c.…”

Section: Discussionmentioning

confidence: 99%

Thymic Rosai-Dorfmann disease: a case report

Liu,

Wang,

Jing

2024

Preprint

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Rosai-Dorfman disease (RDD), known as sinus histiocytosis with massive lymphadenopathy, commonly involves lymph nodes in neck or mediastinum, although extra-nodal involvement was observed in about 40% RDD patients. RDD that merely involved thymus was very rarely reported. We report a RDD case with thymic origin. A 52-year-old male was accidently found to have a 7×6 cm anterior mediastinum lump by chest computed tomography (CT) scan. The mediastinal lesion was resected by surgery and postoperative pathology revealed to be RDD originated from thymus. Regular telephone follow-up after surgery, that was continued for 3 years to date, showed that the patient maintained in good conditions without any relevant symptoms.

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“…Some studies suggest it is thought to be due to immune dysregulation or infections like HHV-6, HHV-8, parvovirus B19 and klebsiella. However, the evidence is inconclusive [ 8 ]. It also remained controversial about the association of IgG4 with RDD.…”

Section: Discussionmentioning

confidence: 99%

“…Though the clinical presentation of RDD is variable, the most common place is painless bilateral cervical lymphadenopathy [ 8 ]. It usually accompanied with other systemic symptoms such as fever, malaise, night sweats, or weight loss in the short term.…”

Section: Discussionmentioning

confidence: 99%

An extremely rare case of Rosai–Dorfman disease in the thymus

Shen

Liao

2021

J Cardiothorac Surg

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Background There were very few reports of Rosai–Dorfman disease in the thymus, which known as sinus histiocytosis with massive lymphadenopathy. It usually accompanied with other systemic symptoms such as fever, malaise, night sweats, or weight loss in the short term. Case presentation We herein report a rare case of RDD of thymic origin and a review of the literature concerning the clinical and pathological features of this disease, which is often misdiagnosed as thymoma. The patient was underwent thymectomy to extirpate the lesion completely by video-assisted thoracic surgery. Conclusions To the best of our knowledge, this is the fourth thymus occurring RDD case with proof via histology and IHC. Our findings suggest the difficulty of making a diagnosis before surgery and more cases will need to be reported in order to facilitate the preoperative diagnosis of such a rare tumor.

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Rosai Dorfman Disease —A rare case of cervical lymphadenopathy

Abstract: This is an open access article under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non-commercial and no modifications or adaptations are made.

Cited by 7 publications

References 7 publications

Rosai-Dorfman Disease Manifesting as a Solitary Mass With Fat in the Thymus

Rosai-Dorfman Disease Manifesting as a Solitary Mass With Fat in the Thymus

Thymic Rosai-Dorfmann disease: a case report

An extremely rare case of Rosai–Dorfman disease in the thymus

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