Rosai-Dorfman Disease with Isolated Laryngeal                     Involvement

Illing, Elisa A.; Halum, Stacey L.

doi:10.1177/014556131209101008

Cited by 7 publications

(2 citation statements)

References 4 publications

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“…Surgical excision and other medical treatments are often reserved for cases with vital organ involvement. 3 Here we report a rare case of Rosai Dorfman disease (RDD) involving the submental region.…”

Section: Introductionmentioning

confidence: 99%

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Rosai Dorfman disease: a case report

Ong¹,

Ping²,

Kiang

et al. 2018

Int J Otorhinolaryngol Head Neck Surg

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<p class="abstract">Rosai Dorfman disease (RDD) is a rare granulomatous disease that typically presents with massive lymphadenopathy. To our knowledge, there have only been 650 cases reported worldwide. It is more common among adults and has characteristic clinical, radiological and histopathological findings. Here, we present a case of RDD in a 51 year-old man with massive submental lymphadenopathy which was not responding to antibiotics. Computerized Tomographic Scan showed ill-defined non-enhancing soft tissue density while fine needle aspiration for cytology displayed emperipolesis which is seen in patients with RDD. The swelling followed a benign course and reduced in size progressively without further intervention.</p><p class="abstract"> </p>

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Section: Introductionmentioning

confidence: 99%

“…1 Involvement of the central nervous system and larynx may need targeted therapies which include surgery, radiotherapy, chemotherapy and immunotherapy. 3 We have opted to manage our patient conservatively and he is currently progressing well with the submental swelling reducing in size.…”

mentioning

confidence: 99%

Rosai Dorfman disease: a case report

Ong¹,

Ping²,

Kiang

et al. 2018

Int J Otorhinolaryngol Head Neck Surg

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Larynx and Hypopharynx

Zidar¹,

Gale²,

Cardesa³

et al. 2016

Pathology of the Head and Neck

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Two rare cases of laryngeal intralymphatic histiocytosis

Reznitsky

Daugaard

Charabi

2015

Eur Arch Otorhinolaryngol

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We report two rare cases of intralymphatic histiocytosis causing, respectively, recurrent and persistent episodes of upper airway swelling and breathing difficulties. Case 1 was a 39-year-old man who was referred with recurrent upper airway swelling causing difficulty in breathing. A direct laryngoscopy was performed under general anesthesia due to minimal effect from treatment with antibiotics and anti-oedema medication. On examination, the larynx was found to be swollen and oedematous but not inflamed. Biopsies from the aryepiglottic folds showed intralymphatic histiocytosis. The patient was extensively examined but the only abnormal finding was a low CD4 count. The breathing difficulties fluctuated during the diagnostic process and settled after a year. Case 2 was a 35-year-old man who presented with persistent laryngeal swelling. Biopsies from the epiglottis showed intralymphatic histiocytosis. Extensive investigations were performed but discovered no abnormal findings. He received CO2 laser treatment twice and the swelling decreased. Intralymphatic histiocytosis is extremely rare in upper airway pathology. It is an important differential diagnosis in patients with recurrent and chronic laryngeal swelling and dyspnoea.

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Rosai-Dorfman Disease with Isolated Laryngeal Involvement

Cited by 7 publications

References 4 publications

Rosai Dorfman disease: a case report

Rosai Dorfman disease: a case report

Larynx and Hypopharynx

Two rare cases of laryngeal intralymphatic histiocytosis

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