Rosai-Dorfman disease with spinal cord compression: a diagnostic challenge

Abstract

This case demonstrates the challenge in making a diagnosis. RDD should be considered as a differential diagnosis in case of spinal lesion and non-diagnostic biopsy, especially in steroid sensitive lesions. The implications of the case are discussed.

Rosai-Dorfman disease of vertebra: Case report and literature review

“…Vertebral body fracture is an extremely rare manifestation of RDD, which was previously reported in only one case 17 . Only 5 cases were described in childhood 5,8,9,12,17 and it is interesting that the same number was recorded in the age group over 50 years 6,13,15,16,18 . In Table I, we presented the comparison of all cases of isolated RDD localized in the spinal column.…”

“…A review of the literature reveals approximately 50 cases with solitary bone lesion as only manifestation of the disease 4 . To the authors' best knowledge; solitary lesions in the spinal column are described in 14 cases [5][6][7][8][9][10][11][12][13][14][15][16][17][18] . Vertebral body fracture is an extremely rare manifestation of RDD, which was previously reported in only one case 17 .…”

Isolated Intramedullary Spinal Rosai–Dorfman Disease in a Child: A Case Report

“…13 On T2-weighted images, RDD usually displays isointense signal, yet lesions with hypo-and hyperintense signal have been reported. 1,13 Heterogeneous hypointense signal on T2-weighted images has been reported for numerous cases and has been proposed to be used as a differentiating point between RDD and meningiomas, which are commonly iso-or hyperintense on T2-weighted images. Calcifications are rarely seen in RDD.…”

“…The lesion displays relatively intermediate signal on T1, as well as on T2 and short tau inversion recovery-weighted images and shows homogenous avid post-contrast enhancement on T1 postcontrast images (►Figs. [1][2][3]. The lesion displayed no calcifications, necrosis, or cystic changes.…”

“…Rosai-Dorfman disease (RDD), also known as sinus histiocytosis with massive lymphadenopathy, is an uncommon benign histiocytic proliferative disorder which was named after J. Rosai and R. F. Dorfman in 1969. 1,2 However, an extensive search of the literature done by Gaitonde revealed that it was first reported by Destombes in 1965. 3,4 Although RDD has been reported in all age groups, it most frequently presents in children and young adults, with a slight male predominance, 5 and it is mainly observed in individuals of African and European descent rather than in Asian populations.…”