Rose Bengal‐Derived Carbon Quantum Dots as a Fluorescence Probe for the Highly Sensitive Detection of Fe³⁺ Ions

Abstract

In this study, rose bengal‐derived carbon quantum dots (RB‐CQDs) was synthesized by a one‐step solvothermal method using rose bengal and 1,2‐phenylenediamine as precursors in ethanol at 180 °C for 10 h and purified by silica gel chromatography. The as‐synthesized RB‐CQDs disperses well in water with particle sizes ranging from 0.78 to 2.46 nm and exhibits excitation‐independent yellow fluorescent emission (529 nm), high quantum yield (44.3 %) and good biocompatibility. More importantly, the fluorescence of RB‐CQDs can be selectively quenched by Fe3+ ions with good linear correlation and the detection limit is 19.9 nM. The recoveries of this method in actual water samples are 90 % to 110 % with relative standard deviations less than 5 %.

Machine-Learning-Enhanced Fluorescent Nanosensor Based on Carbon Quantum Dots for Heavy Metal Detection

“…Detailed machine learning results of the nanosensor for Fe 3+ , Cr 6+ , Pb 2+ , and Hg 2+ with varying concentrations are shown in Figures S5–S19. We compared the results with LOD performances of CQD for each analyte from previous research studies (Figure d). − The results show that with our machine learning integration, the LOD of the CQD nanosensor achieved the lowest LOD level of previous CQD works for each analytes. Overall, this machine learning-integrated technique can significantly improve the detection limit of the fluorescent nanosensor for a variety of analyte targets.…”

Integrin αvβ3-targeted engineered carbon dots for efficacious sonodynamic therapy and fluorescence navigation surgery against gliomas

“…Rose bengal (RB), a commercially available photoactive dye, has generally been exploited as a precursor for the synthesis of CDs given its merits such as low toxicity, good stability, and extraordinary hydrophilicity, as well as excellent optical properties with high fluorescence quantum yields and excitation-independent fluorescence emission. 21,22 In addition, RB also serves as one of the sonosensitizers with the potential for application in SDT and can generate toxic singlet oxygen to eradicate tumorous cells and bacteria under ultrasound irradiation in company with mechanical disruption of cellular membranes. 23 Nevertheless, its broader applications are limited by its rapid clearance and poor accumulation in tumors.…”

Ultrabright Green-Emissive Nanodots for Precise Biological Visualization

“…As the most widely applied biological visualization method, the fluorescence labeling technology has achieved great success in the field of bioimaging, diagnostics, and biosensing owing to its fast responsive speed, simple procedure, and superior sensitivity. − Carbon dots (CDs) are a sort of zero-dimensional photoluminescent nanomaterial with ultrasmall sizes less than 10 nm. − Compared with other small- or macromolecular organic photoluminescent probes, CDs have higher photostability, better biocompatibility, larger tunable fluorescence emission wavelength range, and simpler synthetic methods, − which have gained much attention since their discovery in 2004 . However, some drawbacks of CDs, such as low photoluminescence quantum yield (PLQY), poor water dispersity, and broad photoluminescence bandwidths, have hindered their bioapplication.…”