Rose Bengal Staining and Cytologic Characteristics Associated With Lipid Tear Deficiency

Lee, Shwu‐Huey; Tseng, Scheffer C.G.

doi:10.1016/s0002-9394(14)71690-3

Cited by 89 publications

(33 citation statements)

References 30 publications

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“…Our results are in concordance with Lee and co-workers, 25 who found that the severity of squamous metaplasia correlated well with the intensity of the rose bengal score, and with Pflugfelder et al, 8 who described a correlation between goblet cell density and rose bengal staining. Bjerrum 26 found a correlation between nuclear changes and rose bengal staining, which was also seen in our population.…”

Section: Discussionsupporting

confidence: 93%

Evaluating an impression cytology grading system (IC score) in patients with dry eye syndrome

Schwantzer

Berghold

et al. 2005

Eye

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Purpose To evaluate the IC score, a newly developed grading system for the morphological alterations of the ocular surface as a diagnostic tool in relation to type and severity of dry eye disease. Methods Impression cytological specimens of 309 patients with simple dry eye (S-DE), 50 patients with Sjö gren's syndrome and dry eye (SS-DE), and 39 patients with connective tissue disease and dry eye (CTD-DE) were examined. In all, 10 different morphological parameters were judged with points (IC subscores) and summarized to the IC score. IC score and subscores were correlated to tear function test results and with each other. Results SS-DE patients had the highest IC scores and IC subscores. IC scores and IC subscores correlated significantly with the fluorescein staining of the cornea in all three patient groups. They were correlated to the rose bengal score in SS-DE and S-DE patients. The analysis of the IC subscores showed that there are significant correlations between most of the morphological alterations investigated. This underlines the importance of each parameter for the summarized IC score. Conclusion The IC score provides detailed information about the morphological alterations of the bulbar conjunctiva. It has proven to be useful for the differentiation of dry eye diseases and might help in the investigation of the pathogenesis of these diseases as well as for follow-up and therapy control.

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Section: Discussionsupporting

confidence: 93%

Evaluating an impression cytology grading system (IC score) in patients with dry eye syndrome

Schwantzer

Berghold

et al. 2005

Eye

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“…Group B: any of the following eye symptoms, scratchy or sandy sensation, itching, burning, redness and photosensitivity; noninflamed meibomian gland dysfunction (MGD) and SIT ‡ 10 mm ⁄ 5 min. The criteria of noninflamed MGD included the presence of meibomian gland dropout by transillumination through the tarsus, no or poor meibum expression in response to digital pressure, lack of active inflammation, and the presence of meibomian gland orifice squamous metaplasia or acinar atrophy (Goto et al 2002;Lee & Tseng 1997;Shimazaki et al 1995Shimazaki et al , 1998. Group C: patients with SS were diagnosed and enrolled according to the criteria of Fox and colleagues (Fox et al 1986;Vitali et al 2002).…”

Section: Dry Eye Groupmentioning

confidence: 99%

The diagnostic significance of Fourier‐domain optical coherence tomography in Sjögren syndrome, aqueous tear deficiency and lipid tear deficiency patients

Qiu

Gong

et al. 2012

Acta Ophthalmologica

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ABSTRACT.Purpose: To determine the role of Fourier-domain optical coherence tomography (FD-OCT) in tear meniscus imaging and evaluate its diagnostic significance in Sjo¨gren syndrome (SS), non-Sjo¨gren's aqueous tear deficiency (ATD) and lipid tear deficiency (LTD) patients. Methods: Two hundred and thirty-six dry eye patients and 174 healthy controls were enrolled in this study. All subjects were grouped as follows: group A (ATD), group B (LTD), group C (SS) and group D (normal controls). All subjects underwent dry eye questionnaire, FD-OCT scanning, tear film break-up time (BUT), corneal fluorescence staining and Schirmer I test (SIT). Tear meniscus height (TMH), tear meniscus depth (TMD) and tear meniscus cross-sectional area (TMA) were measured using FD-OCT (RTVue-100). The area under the receiver operating characteristic curve and the cut-off point were determined using a logistic regression model. Results: Mean TMH, TMD, TMA, BUT and SIT of dry eye patients were significantly lower than those of the controls (p < 0.05). Tear meniscus values were significantly decreased in patients with SS compared with ATD and LTD patients. Tear meniscus values were significantly correlated with clinical examination results in all groups. Accuracy of dry eye diagnosis by FD-OCT is highest in patients with SS and lowest in LTD patients. The clinical diagnostic critical points were quite different between groups. Conclusions: Fourier-domain optical coherence tomography could provide precise measurement of the tear meniscus with favourable repeatability. Diagnostic significance is more conspicuous in patients with SS. Tear meniscus measurement by FD-OCT is expected to become a valuable technique in ATD dry eye screening and diagnosis.

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“…1 Obstructive meibomian gland dysfunction (MGD) is characterized by the condensation of meibomian lipids 2 and is a major cause of lipid layer defi ciency and evaporative dry eye. [3][4][5][6] Comprehensive diagnostic criteria for obstructive MGD are not yet established. In a recent study, we proposed that the ocular symptom score, lid margin abnormality score, and a score for morphologic changes of the meibomian glands observed with meibography (meiboscore) can be used to diagnose MGD.…”

Section: Introductionmentioning

confidence: 99%

Efficacy of diagnostic criteria for the differential diagnosis between obstructive meibomian gland dysfunction and aqueous deficiency dry eye

Arita

Itoh

Maeda³

et al. 2010

Jpn J Ophthalmol

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Although the criteria were moderately reliable for differentiating patients with obstructive MGD from those with ADDE when the diagnosis of obstructive MGD was made on the basis of three abnormal scores, they do not provide comprehensive diagnostic tools for differentiating MGD, ADDE, and healthy individuals. We need to add other parameters such as the Schirmer test value and the meibum score to the diagnostic criteria to enhance their reliability for differentiating MGD and ADDE.

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Rose Bengal Staining and Cytologic Characteristics Associated With Lipid Tear Deficiency

Cited by 89 publications

References 30 publications

Evaluating an impression cytology grading system (IC score) in patients with dry eye syndrome

Evaluating an impression cytology grading system (IC score) in patients with dry eye syndrome

The diagnostic significance of Fourier‐domain optical coherence tomography in Sjögren syndrome, aqueous tear deficiency and lipid tear deficiency patients

Efficacy of diagnostic criteria for the differential diagnosis between obstructive meibomian gland dysfunction and aqueous deficiency dry eye

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