Rosehip Extract-Loaded Liposomes for Potential Skin Application: Physicochemical Properties of Non- and UV-Irradiated Liposomes

Abstract

In the present study, rosehip (Rosa canina L.) extract was successfully encapsulated in phospholipid liposomes using a single-step procedure named the proliposome method. Part of the obtained liposomes was subjected to UV irradiation and non-treated (native) and UV-irradiated liposomes were further characterized in terms of encapsulation efficiency, chemical composition (HPLC analysis), antioxidant capacity, particle size, PDI, zeta potential, conductivity, mobility, and antioxidant capacity. Raman spectroscopy as well as DSC analysis were applied to evaluate the influence of UV irradiation on the physicochemical properties of liposomes. The encapsulation efficiency of extract-loaded liposomes was higher than 90%; the average size was 251.5 nm; the zeta potential was −22.4 mV; and the conductivity was found to be 0.007 mS/cm. UV irradiation did not cause a change in the mentioned parameters. In addition, irradiation did not affect the antioxidant potential of the liposome–extract system. Raman spectroscopy indicated that the extract was completely covered by the lipid membrane during liposome entrapment, and the peroxidation process was minimized by the presence of rosehip extract in liposomes. These results may guide the potential application of rosehip extract-loaded liposomes in the food, pharmaceutical, or cosmetic industries, particularly when liposomal sterilization is needed.

Unveiling the mechanisms for the development of rosehip-based dermatological products: an updated review

“…In a different research, RO-encapsulated liposomes may be safely and potentially used in the cosmetic industry, as UV-irradiation did not alter the physical properties (particularly liposome size) or antioxidant capacities of rosehip-loaded liposomes ( Jovanović et al, 2023b ). Although minimized peroxidation process and complete coverage have been observed, UV-irradiation caused a decrease in the levels of individual components of rosehip (i.e., quercetin, rutin, and chlorogenic acid), implying their susceptibility to oxidation or isomerisation ( Jovanović et al, 2023a ).…”

Liposome Encapsulation Enhances the Antidiabetic Efficacy of Silibinin

“…The functionality, stability, and bioavailability of bioactive plant compounds, including silibinin, depend on various factors such as temperature, irradiation, light, enzymes, pH, free radicals, and storage conditions. Therefore, the main advantages of encapsulating these sensitive bioactives in different carriers are improved stability during storage, protection from environmental and/or gastrointestinal conditions, better bioavailability, and controlled and/or prolonged release [ 20 ]. To date, various delivery systems have been explored to improve the water solubility and efficacy of orally administered phytoconstituents [ 19 ].…”

“…Liposomal vesicles represent a revolutionary class of drug delivery systems that can transport therapeutic payloads with precision and efficiency. The unique composition of these particles not only enables controlled release and targeted delivery but also increases bioavailability and biocompatibility, making liposomes a disruptive force in modern medicine [ 20 , 21 , 22 ]. Due to their amphiphilic nature, liposomal vesicles are able to encapsulate both lipophilic and hydrophilic components [ 23 , 24 ].…”

Exploration of New Lipid Nutrients and Their Characterization in Herbal Teas Using Non-Targeted Liquid Chromatography–Mass Spectrometry

“…Fatty acids extracted from orange peel include palmitic acid, stearic acid, oleic acid, linoleic acid, linolenic acid, and lignoceric acids, and essential oils, which have an antibacterial activity [ 28 ] and insecticidal activity [ 29 ]. Rosehip, also known as rose haw, is a fruit of various rose plants used in pharmaceutical and cosmetic industries and has been encapsulated in phospholipid liposomes using the single-step pro-liposome method [ 30 ]. Rosehip is also considered for its preventive and curative properties against a wide range of renal, inflammatory, gut, and gastric diseases [ 31 ], as well as for its antioxidant, antibacterial, analgesic, mild laxative, diuretic, anti-cancer, and positive effects on dermatoses, ulcers, and skin diseases [ 32 , 33 ].…”