Rosemary extract ameliorates cadmium-induced histological changes and oxidative damage in the liver of albino rat

Sakr, Saber A.; Bayomy, Mohammed; El-Morsy, A.M.

doi:10.1016/j.jobaz.2015.01.002

Cited by 30 publications

(29 citation statements)

References 33 publications

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“…1d). These results were also reported by other researchers [45][46]. According to Leo et al, (1982) [47] the vaculoation of the liver cells can be attributed to the swelling of mitochondria and proliferation of endoplasmic reticulum.…”

Section: Liver Histopathologysupporting

confidence: 86%

Protective Potential of Quercetin on Cd-Induced Hepatorenal Damage

Sedky¹,

Mahboub²,

Eid³

2017

Pol. J. Environ. Stud.

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Section: Liver Histopathologysupporting

confidence: 86%

Protective Potential of Quercetin on Cd-Induced Hepatorenal Damage

Sedky¹,

Mahboub²,

Eid³

2017

Pol. J. Environ. Stud.

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“…Administration of plant extracts in cadmiumintoxicated rabbits may protect the enzymatic and nonenzymatic antioxidants by means of either their metal chelation activity or by their antioxidant activities, which might reduce the exploitation of these antioxidants, thus reinstating their levels to near normal as described by Sakr et al [48].…”

Section: Status Of Urine and Serum Renal Markermentioning

confidence: 96%

Investigating the Ameliorative Potential of the Aloe barbadensis Aqueous Fraction on Oxidative Stress Markers and Biochemical Parameters in Cadmium-Intoxicated Rabbits

Hussain

Chaudhry

Anjum

et al. 2016

Pol. J. Environ. Stud.

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This study was conducted to evaluate the possible protective effects of the flavonoid-rich fraction of Aloe barbadensis leaf skin on cadmium (Cd)-induced toxicity in male albino rabbits. Cadmium is a notable environmental pollutant due to its wider range of toxic manifestations. The aqueous fraction of aloe extract (AAF) showed higher phenolics, flavonoids, and antioxidant capacity among other fractions, suggesting its rationale use in this study. Twenty-four rabbits were randomly divided into four groups, including the control group (receiving only vehicle), the Cd group (receiving Cd, 5.1 mg/kg/day), the AAF groups (receiving AAF, 200 mg/Kg/day), and the Cd+AAF group (receiving the same concentrations as the Cd and AAF groups). Oral treatment over a period of 40 days significantly increased (p<0.05) biochemical marker enzymes, including transaminases (AST, ALT), alkaline phosphatase, γ-glutamyl transferase, creatinine, and urea, while total bilirubin (Tb) and albumin were decreased on days 10, 20, 30, and 40 in the Cd group as compared to control. A significant decrease (p<0.05) in enzyme levels and increases in Tb and albumin for Cd+AAF were observed as compared to Cd-treated rabbits. Contents of superoxide dismutase, catalase, and vitamins C and E in liver and kidney tissues were significantly increased (p<0.05), while cadmium content was significantly decreased (p<0.05) for Cd+AAF rabbits as compared to Cd-intoxicated rabbits. Values of all the parameters in only the AAF group were near to control. The histopathological studies for liver and kidney have also supported the Cd+AAF group markedly reducing the toxicity of Cd in both tissues to near normal. Thus, the results suggest that the flavonoid-rich fraction of AAF may

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“…Our findings are in accordance with [51][52], who showed that the level of vitamin C and vitamin E are significantly reduced during Cd-intoxication, leading to the development of Cdinduced hepatic and renal impairment. The administration of plant extracts in Cd-intoxicated rabbits may protect the enzymatic and non-enzymatic antioxidants by means of either their metal chelation activity or by their antioxidant activities that might reduce the exploitation of these antioxidants, thus reinstating their levels to near normal as described by [53].…”

Section: Determination Of Antioxidant Enzymesmentioning

confidence: 99%

Amelioration of Hepato-Renal Toxicity by a Flavonoid-Rich Fraction of Hibiscus rosa-sinenses (Leaves and Flowers) in Male Rabbits Intoxicated by Cadmium

Hussain

Chaudhary

Anjum

et al. 2017

Pol. J. Environ. Stud.

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This study was initiated to anticipate the potential protective effects of flavonoid-rich fractions of Hibiscus rosa-sinenses flowers (HF) and leaves (HL) on cadmium (Cd)-induced toxicity in adult albino rabbits. Cd, being a prominent environmental pollutant, poses a threat for its widespread range of toxic expressions. A dramatic increase in total phenolics, flavonoids, and antioxidant capacity has been observed in flavonoid-rich fractions of HF and HL as compared to their crude extracts, suggesting for the rationale for their use in this study. Thirty-six male rabbits were indiscriminately allocated into six groups, including control, Cd (6.1 mg Cd/kg/day), HF and HL (200 mg HF & HL /Kg/day), Cd+HF, and Cd+HL (receiving the same doses of Cd, HF, and HL) groups. Treatment (p.o) for 60 days resulted in improvement of weight gain in Cd+HF and Cd+HL groups in comparison with the Cd group. Treatment with Cd+HF showed better results than Cd+HL by significantly decreasing (p<0.05) transaminases (AST, ALT), alkaline phosphatase (ALP), gamma glutamyl transferase (GGT), and creatinine and urea levels, while total bilirubin and albumin were increased on the 15 th , 30 th , 45 th , and 60 th days in a progressive manner when compared with the Cd receiving group. Likewise, the Cd+HF group showed better activities than Cd+HL by significantly increasing (p<0.05) superoxide dismutase, catalase, and vitamins C and E, while LPO and Cd concentrations were significantly decreased in the liver and kidney tissues when compared with Cd-intoxicated bucks.Values of these parameters in only HF and HL-receiving groups were near the control. The histopathological

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Rosemary extract ameliorates cadmium-induced histological changes and oxidative damage in the liver of albino rat

Cited by 30 publications

References 33 publications

Protective Potential of Quercetin on Cd-Induced Hepatorenal Damage

Protective Potential of Quercetin on Cd-Induced Hepatorenal Damage

Investigating the Ameliorative Potential of the Aloe barbadensis Aqueous Fraction on Oxidative Stress Markers and Biochemical Parameters in Cadmium-Intoxicated Rabbits

Amelioration of Hepato-Renal Toxicity by a Flavonoid-Rich Fraction of Hibiscus rosa-sinenses (Leaves and Flowers) in Male Rabbits Intoxicated by Cadmium

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