Rosette Formation in Plasmodium falciparum Isolates and Anti-Rosette Activity of Sera from Gambians with Cerebral or Uncomplicated Malaria

Treutiger, Carl-Johan; Hedlund, Iris; Helmby, Helena; Carlson, Johan E.; Jepson, Annette; Twumasi, Patrick; Kwiatkowski, Dominic; Greenwood, Brian; Wahlgren, Mats

doi:10.4269/ajtmh.1992.46.503

Cited by 150 publications

(98 citation statements)

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“…An association between human cerebral malaria and erythrocyte rosetting was described based on a study performed in The Gambia (Carlson et al, 1990), in which all isolates from patients with cerebral malaria formed rosettes and in which the mean percentage of parasitized erythrocytes involved in rosetting was twice as high as in the isolates from patients with uncomplicated malaria. Similar findings were also reported from a study in Thailand (Ho et al, 1991), and another investigation conducted in The Gambia showed that giant rosettes formed more frequently in isolates from patients with cerebral malaria than in isolates from patients with uncomplicated malaria (Treutiger et al, 1992).…”

Section: Rosette Formationsupporting

confidence: 78%

Pathology and pathophysiology of malaria.

Kano

Aikawa

1999

Jap. J. Trop. Med. Hyg.

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Abstract:Pathological processes in malaria are the consequence of the erythrocytic cycle of the parasites. Merozoites invade erythrocytes, in which they develop through early trophozoites (ring forms) to late trophozoites and eventually to schizonts. During this process, development of knobs and cytoadherence or rosetting with the knobs play important roles for the falciparum malaria patient to be severely ill.Expression of variant surface neoantigens stimulates the reticuloendothelial system and can cause anemia, tissue hypoxia and cytokine production. Associated fever, paroxysms, headache and other pains are thought to result from cytokines such as interleukins, interferons and tumor necrosis factor released from macrophages or other cells at the time of schizont rupture.In the present paper, pathological and pathophysiological changes mainly in human falciparum malaria are reviewed, emphasizing the importance of basic research to "roll back" the emerging trends of malaria.

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Section: Rosette Formationsupporting

confidence: 78%

Pathology and pathophysiology of malaria.

Kano

Aikawa

1999

Jap. J. Trop. Med. Hyg.

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“…Together, these can lead to coma, organ failure and death. Many studies, both in vitro and in vivo, have shown associations between binding ability to at least some host cell receptors (principally CD36, ICAM-1 and CR1) and the occurrence of the most severe forms of disease (MacPherson et al 1985;Carlson et al 1990;Ho et al 1991;Pongponratn et al 1991;Treutiger et al 1992;Ringwald et al 1993;Rowe et al 1995;Newbold et al 1997Newbold et al , 1999Kun et al 1998;Roberts et al 2000;Pain et al 2001), whereas a few studies have found no such relationship al-Yaman et al 1995;Angkasekwinai et al 1998;Rogerson et al 1999) or a reverse one (Rogerson et al 1999). However, there is a lot to understand about how exactly cytoadherence leads to severe pathology (Berendt et al 1994;Clark & Rockett 1994;Clark & Schofield 2000;Cooke et al 2000).…”

Section: Molecular Mechanisms For Virulence In Relation To Parasite Fmentioning

confidence: 99%

Virulence in malaria: an evolutionary viewpoint

Mackinnon

Read

2004

Phil. Trans. R. Soc. Lond. B

228

205

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Malaria parasites cause much morbidity and mortality to their human hosts. From our evolutionary perspective, this is because virulence is positively associated with parasite transmission rate. Natural selection therefore drives virulence upwards, but only to the point where the cost to transmission caused by host death begins to outweigh the transmission benefits. In this review, we summarize data from the laboratory rodent malaria model, Plasmodium chabaudi, and field data on the human malaria parasite, P. falciparum, in relation to this virulence trade-off hypothesis. The data from both species show strong positive correlations between asexual multiplication, transmission rate, infection length, morbidity and mortality, and therefore support the underlying assumptions of the hypothesis. Moreover, the P. falciparum data show that expected total lifetime transmission of the parasite is maximized in young children in whom the fitness cost of host mortality balances the fitness benefits of higher transmission rates and slower clearance rates, thus exhibiting the hypothesized virulence trade-off. This evolutionary explanation of virulence appears to accord well with the clinical and molecular explanations of pathogenesis that involve cytoadherence, red cell invasion and immune evasion, although direct evidence of the fitness advantages of these mechanisms is scarce. One implication of this evolutionary view of virulence is that parasite populations are expected to evolve new levels of virulence in response to medical interventions such as vaccines and drugs.

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“…8 Interestingly, some strains of Plasmodium falciparum preferentially trigger rosette formation depending on the red blood cell blood group, with A and B group cells being more likely to form rosettes. 9,10 Our experience in Zimbabwe suggested that severe malaria was relatively more frequent in individuals in the non-O blood groups.…”

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confidence: 99%

Short report: severe malaria associated with blood group.

Fischer

Boone²

1998

The American Journal of Tropical Medicine and Hygiene

106

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Abstract. The ABO blood groups are not linked to the incidence of simple malaria infection but have been associated with rosette formation. In an effort to see if clinically severe malaria is associated with blood group, 489 patients were studied in Zimbabwe. Patients with malaria and group A blood had lower hemoglobin levels and more risk of coma than did infected patients with other blood groups. In this population, severe malaria is associated with blood group.

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Rosette Formation in Plasmodium falciparum Isolates and Anti-Rosette Activity of Sera from Gambians with Cerebral or Uncomplicated Malaria

Cited by 150 publications

References 0 publications

Pathology and pathophysiology of malaria.

Pathology and pathophysiology of malaria.

Virulence in malaria: an evolutionary viewpoint

Short report: severe malaria associated with blood group.

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