Rosette-Forming-Lymphocyte Counts in Cancer of the Colon

Seitanides, B.; Georgoulis, B

doi:10.1016/s0140-6736(75)91539-1

Cited by 8 publications

(3 citation statements)

References 3 publications

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“…Evidence that decreased lymphocyte counts in patients with carcinomas may be reflecting the host's cellular immune responses is provided by the similarity of changes in peripheral lymphocytes and T cells (12) observed in patients with colon cancer. A correlation between tumor stage and lymphocyte counts in patients with colon and breast cancer has been recently reported (5,8).…”

Section: Discussionmentioning

confidence: 99%

“…Peripheral lymphocyte and T-cell counts have been previously linked with immunological responses in a variety of neoplastic conditions, and a prognostic value has been attributed to their levels (3,(10)(11)(12)14). The CEA assay appears to have similar prognostic value ( 2 , 7 ) while decreased immunogenicity through inhibition of cellular immune responses has been linked with high CEA levels ( 6 ) .…”

Section: Discussionmentioning

confidence: 99%

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Prognostic significance of peripheral lymphocyte counts and carcinoembryonic antigens in colorectal carcinoma

Kim

Papatestas

Aufses

1976

Journal of Surgical Oncology

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An association between pretreatment lymphocyte counts and 5-year prognosis was noted in colorectal cancer. Among 188 patients with 5-year follow-up significant difference in survival rates in relation to lymphocyte counts was noted: 61% for patients with counts greater than 2,000/cm, 30% for those with counts less than 1,000/cmm, and 58% for the intermediate group. Similar differences were also noted within groups with Dukes' B and C lesions and in elderly patients. Highly significant differences were noted in women. Those with Dukes' B and C lesions with counts greater than 2,000/cmm had an 81% survival rate, compared to 50% for those with lower counts X2 = 6.81 P LESS THAN 0.01. Women had significantly higher lymphocyte counts and higher survival rates than men. An inverse correlation was noted between pretreatment lymphocytes and simultaneously determined carcinoembryonic antigens. These observations indicate that lymphocyte counts may be of prognostic value in colorectal cancer when used in association with carcinoembryonic antigens.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Prognostic significance of peripheral lymphocyte counts and carcinoembryonic antigens in colorectal carcinoma

Kim

Papatestas

Aufses

1976

Journal of Surgical Oncology

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“…Fifteen out of 19 patients who were eventually shown to have cancer recorded ARFC < 1504 (the value shown by Wybran and coworkers to be the lower limit for normal individuals). while none of 14 patients with other gastrointestinal conditions recorded values < 1504 and the four patients with cancer with ARFC > 1504 had values of 18-304, 18.8%,16.904 and 20'7%.…”

mentioning

confidence: 89%

Increased Active Rosette Formation in Patients with Gastrointestinal Cancer after Enzyme Treatment of Lymphocytes In Vitro*

Walters

Rutherford

Wall

1978

Australian and New Zealand Journal of Medicine

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Summary: Increased active rosette formation in patients with gastrointestinal cancer after enzyme treatment of lymphocytes in vitro. B. A. J. Walters, J. C. Rutherford and J. R. Wall, Aust. N.Z. J. Med., 1978, 8, pp. 610–614. Total rosette forming cells (RFC) and active rosette forming cells (ARFC) were estimated in 33 patients presenting with gastrointestinal symptoms suggestive of cancer. When the 33 patients were grouped according to whether they had cancer or not, there was a distinct difference in the percentage of ARFC (P < 0001 Mann‐Whitney Test); patients with cancer having much lower values (mean 11 6 ±4–5) than patients without cancer (mean 27 2 ± 3–6). Total RFC were generally lower in the cancer group (mean 54‐8 ± 8‐3) than the non‐cancer group (mean 71‐9 ± 4–5) a/though the range was greater. After treatment of the lymphocytes with papain, the percentage of ARFC increased. In the non‐cancer group the levels reached a mean of 74‐8 ± 1–8, indicating that the T lymphocyte population (mean 71‐9 ± 4–5) was converted into cells all having high affinity receptors for sheep red blood cells (SRBC). In the cancer group, after papain treatment of the lymphocytes, the percentage of ARFC increased to levels greater than that obtained for total RFC, suggesting a contribution from the null cell population. Serum taken from these patients was shown to produce a decrease in the percentage ARFC obtained from normal, young individuals. Further, this decrease could be partially reversed by papain digestion indicating that serum from cancer patients may contain a factor that masks T

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Immune reactivity in patients with colorectal cancer: Assessment of biologic risk by immunoparameters

Wanebo¹,

Rao²,

Attiyeh³

et al. 1980

Cancer

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The concept whether immune reactivity was intrinsically related to risk of recurrence was examined in 307 patients with rectal colon cancer, including 181 patients with primary resectable cancer, 48 patients with advanced primary operable cancer, and 78 patients with recurrence. Immune reactivity was measured by 2,4-dinitrochlorobenzene (DNCB) skin tests (219 patients) and by in vitro immunoparameters (1 10 patients) including lymphocyte levels and lymphocyte stimulation tests with mitogens and antigens. There was a linear depression of immune reactivity as measured by DNCB, phytohemagglutinin (PHA) response, and lymphocyte count with increasing stage of disease (P < -05). Immunity was depressed even in patients with Dukes' A cancer (24% were DNCB negative, 33% had low PHA) and was more depressed in patients with Dukes' Band C lesions (40% were DNCB negative, 30% had low PHA), but was profoundly depressed in patients with advanced primary cancer or recurrence (60% had depression of DNCB, PHA, and lymphocyte counts).Short-term prognosis was examined according to DNCB, lymphocyte count, and mitogen responses in patients with resected Dukes' A, B, and C cancers. There was no correlation of recurrence rates in Dukes' C patients with DNCB, lymphocyte count, or the mitogens PHA, Con A o r pokeweed mitogen (PWM). In contrast, tests with CEA have shown a significant correlation of elevated levels with increased recurrence rates in patients with Dukes' C. There were no correlations of any of the immune tests with recurrence rates in Dukes' A or B, although the follow-up is still short (median 48 months), and the median diseasefree survival has not yet been reached. Only patients with advanced disease (liver metastases) showed correlation of immune responses (PHA and lymphocyte count but not DNCB) with survival, P < .05.

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Rosette-Forming-Lymphocyte Counts in Cancer of the Colon

Cited by 8 publications

References 3 publications

Prognostic significance of peripheral lymphocyte counts and carcinoembryonic antigens in colorectal carcinoma

Prognostic significance of peripheral lymphocyte counts and carcinoembryonic antigens in colorectal carcinoma

Increased Active Rosette Formation in Patients with Gastrointestinal Cancer after Enzyme Treatment of Lymphocytes In Vitro*

Immune reactivity in patients with colorectal cancer: Assessment of biologic risk by immunoparameters

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