Rosiglitazone, a PPAR-γ ligand, protects against burn-induced oxidative injury of remote organs

Liver apoptosis is age dependent and is reduced by activation of peroxisome proliferator-activated receptor-γ in hemorrhagic shock

“…The protective effect was associated with downregulation of the local expression of several potent proinflammatory cytokines, chemokine adhesion molecules, and neutrophil accumulation (2). PPAR␥ ligands have also inhibitory effects on generation of reactive oxygen species and lipid peroxidation in the liver (28,32). Consistent with these previous findings, in the present study we have demonstrated that ciglitazone reduced liver neutrophil infiltration in both age groups.…”

Etanercept protects remote organ damage in a rat model of thermal injury

“…Evidence from animal and human studies suggested that there is a correlation between the tissue MDA levels and the degree of burn complications, including shock and remote organ damage (32)(33)(34)(35). In the present study, burn-induced increase in the lung MDA levels were prevented by etanercept treatment, suggesting that antagonism of TNF- exerts a potent protective effect against lipid peroxidation.…”

Reduced rate of adenosine triphosphate synthesis by in vivo 31P nuclear magnetic resonance spectroscopy and downregulation of PGC-1β in distal skeletal muscle following burn

“…Indeed, recent clinical studies indicated that PGC-1α agonists can alleviate post-burn insulin resistance (34,35) and prevent burn-induced damage in remote organs (36). That PGC-1ß is a highly inducible factor in most tissues and responds to common pathways of calcium and cAMP signaling strongly suggests that it may be possible to find drugs that induce PGC-1ß.…”