Rosinidin Protects Streptozotocin-Induced Memory Impairment-Activated Neurotoxicity by Suppressing Oxidative Stress and Inflammatory Mediators in Rats

Abstract

Background and Objectives: To assess the antioxidant and neuroprotective role of rosinidin on rat memory impairment that is induced by streptozotocin. Materials and Methods: Wistar rats were given an intraperitoneal (i.p) injection of streptozotocin (60 mg/kg) followed by treatment with rosinidin at selective doses (10 and 20 mg/kg) for 30 days. The behavioral parameters were estimated by Y-maze test and Morris water test. Biochemical parameters such as acetylcholinesterase (AChE), choline aacetyltransferase (ChAT), and nitric oxide, and antioxidants such as glutathione transferase (GSH), superoxide dismutase (SOD) IL-6, IL-10, Nrf2, and BDNF, were determined. Results: The study results revealed that rosinidin improved cognition by reverting the behavioral parameters. The treatment with rosinidin restored the antioxidant enzymes and inflammatory cytokines. Conclusions: From the results, it has been proven that rosinidin possesses antioxidant, anti-amnesic, and anti-inflammatory activity. Rosinidin improved the cognitive and behavioral deficits that were induced by streptozotocin. Furthermore, 20 mg/kg rosinidin was found to have strong protective action against streptozotocin-induced toxicity.

Palm Oil Derived Tocotrienol-Rich Fraction Attenuates Vascular Dementia in Type 2 Diabetic Rats

“…Acetylcholine (ACh) plays a significant role in cholinergic neuron functioning in the hippocampus and controls the learning and memory process [ 63 ]. In the cholinergic system, choline acetyltransferase (ChAT) and AChE are involved in the synthesis and metabolism of ACh, respectively; however, STZ administration increases AChE activity [ 64 ]. The increased AChE activity leads to decreased ACh concentration that affects cognitive functioning [ 65 ].…”

Phillyrin Ameliorates Oxidative Stress in D-Galactose-Induced Senescence in the Brain of Mice by Regulating the Nrf2/ HO-1 Signaling Pathway

“…To assess the spatial cognitive ability of mice, the MWM test was performed in the eighth week, and the whole water maze test includes positioning navigation trail and spatial probe test. 23,24 In the positioning navigation trail, mice were put into the water facing the wall of the pool at a regular time period every day, and the time it takes to search for and climb onto a platform was recorded as the escape latency. Each mouse received daily training from four different quadrants for five consecutive days.…”

Biomarkers in Alzheimer Disease and Other Dementias: What’s Next into Pathophysiology to Support Clinical Practice and Drug Development

“…In the future, biomarkers should be available not only for early diagnosis, but also for indicating responses to specific therapeutic interventions that help to guide treatment decisionsfor AD. Alharbi et al [ 6 ] demonstrated the anti-inflammatory and anti-oxidant action of rosinidin in streptozotocin-induced rats, improving their cognitive and spatial learning behavior. These are promising results and suggest rosinidinas a therapeutical agent for further neurodegenerative disorder-related clinical trials.…”