Rosmarinic acid alleviates ethanol-induced lipid accumulation by repressing fatty acid biosynthesis

Guo, Chang; Shangguan, Yu; Zhang, Meiru; Ruan, Yanxin; Xue, Guoqing; Ma, Jingfan; Yang, Jian; Qiu, Longxin

doi:10.1039/c9fo02357g

Cited by 23 publications

(10 citation statements)

References 54 publications

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“…15,22–24 For example, rosmarinic acid ameliorates ethanol-induced injury in the mouse hepatocyte cell line (AML12) by anti-lipid accumulation, anti-oxidative stress, and anti-inflammation. 25 It displays hypolipidemic effects in orotic acid-induced non-alcoholic fatty liver disease rat model rats. 26 It also protects rats against streptozotocin-induced hyperlipidemia, oxidative stress, inflammation, and tissue damage.…”

Section: Discussionmentioning

confidence: 99%

Rosmarinic acid ameliorated psoriatic skin inflammation in mice through the novel inhibition of the interleukin-17A/interleukin-17A receptor interaction

Liu

et al. 2022

Food Funct.

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Section: Discussionmentioning

confidence: 99%

Rosmarinic acid ameliorated psoriatic skin inflammation in mice through the novel inhibition of the interleukin-17A/interleukin-17A receptor interaction

Liu

et al. 2022

Food Funct.

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“…Based on the network pharmacology analysis, a total of 17 active components of SGN were screened out, and the drug-component-target network model was constructed; the key active components were mainly isofraxidin, astilbin, and rosmarinic, caffeic, neochlorogenic, and chlorogenic acid. Previous studies have demonstrated that rosmarinic acid and astilbin exhibit various pharmacological activities, such as anti-inflammatory ( Chu et al, 2012 ), hepatoprotective ( Guo et al, 2020 ), and anti-oxidative activities ( Sharma et al, 2020 ; Wang et al, 2020 ). Phenolic compounds, including neochlorogenic, chlorogenic, cryptochlorogenic, and caffeic acid, can treat metabolic syndrome since they exert anti-oxidative, anti-inflammatory, and antilipidemic effects ( Banjari et al, 2017 ; Santana-Galvez et al, 2017 ; Zhao et al, 2020 ).…”

Section: Discussionmentioning

confidence: 99%

Assessment of the Potential of Sarcandra glabra (Thunb.) Nakai. in Treating Ethanol-Induced Gastric Ulcer in Rats Based on Metabolomics and Network Analysis

Wen

Liu

et al. 2022

Front. Pharmacol.

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Gastric ulcer (GU) is one of the most commonly diagnosed diseases worldwide, threatening human health and seriously affecting quality of life. Reports have shown that the Chinese herbal medicine Sarcandra glabra (Thunb.) Nakai (SGN) can treat GU. However, its pharmacological effects deserve further validation; in addition, its mechanism of action is unclear. An acute gastric ulcer (AGU) rat model induced by alcohol was used to evaluate the gastroprotective effect of SGN by analysis of the histopathological changes in stomach tissue and related cytokine levels; the potential mechanisms of action of SGN were investigated via serum metabolomics and network pharmacology. Differential metabolites of rat serum were identified by metabolomics and the metabolic pathways of the identified metabolites were enriched via MetaboAnalyst. Furthermore, the critical ingredients and candidate targets of SGN anti-AGU were elucidated. A compound-reaction-enzyme-gene network was established using Cytoscape version 3.8.2 based on integrated analysis of metabolomics and network pharmacology. Finally, molecular docking was applied to verify the acquired key targets. The results showed that SGN exerted a certain gastroprotective effect via multiple pathways and targets. The effects of SGN were mainly caused by the key active ingredients isofraxidin, rosmarinic, and caffeic acid, which regulate hub targets, such as PTGS2, MAPK1, and KDR, which maintain the homeostasis of related metabolites. Signal pathways involved energy metabolism as well as immune and amino acid metabolism. Overall, the multi-omics techniques were proven to be promising tools in illuminating the mechanism of action of SGN in protecting against diseases. This integrated strategy provides a basis for further research and clinical application of SGN.

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“…Since ancient times, RA has been used in folk medicine, cosmetics, and dietary supplements. The health-promoting benefits of RA could be based on scavenging reactive oxidation species, decreasing nitric oxide production, lipid peroxidation, increasing high-density lipoprotein, decreasing low-density lipoprotein levels, and deranged hemolysis (Baba et al 2004 ; Guo et al 2020 ). Nyandwi et al ( 2021b ) has reported lipid-lowering effects of RA through modulation of reverse cholesterol transport-related proteins, thereby combating hyperlipidemia-based disorders.…”

Section: Pharmacological Properties Of Ramentioning

confidence: 99%

Biomedical features and therapeutic potential of rosmarinic acid

et al. 2022

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For decades, the use of secondary metabolites of various herbs has been an attractive strategy in combating human diseases. Rosmarinic acid (RA) is a bioactive phenolic compound commonly found in plants of Lamiaceae and Boraginaceae families. RA is biosynthesized using amino acids tyrosine and phenylalanine via enzyme-catalyzed reactions. However, the chemical synthesis of RA involves an esterification reaction between caffeic acid and 3,4-dihydroxy phenyl lactic acid contributing two phenolic rings to the structure of RA. Several studies have ascertained multiple therapeutic benefits of RA in various diseases, including cancer, diabetes, inflammatory disorders, neurodegenerative disorders, and liver diseases. Many previous scientific papers indicate that RA can be used as an anti-plasmodic, anti-viral and anti-bacterial drug. In addition, due to its high anti-oxidant capacity, this natural polyphenol has recently gained attention for its possible application as a nutraceutical compound in the food industry. Here we provide state-of-the-art, flexible therapeutic potential and biomedical features of RA, its implications and multiple uses. Along with various valuable applications in safeguarding human health, this review further summarizes the therapeutic advantages of RA in various human diseases, including cancer, diabetes, neurodegenerative diseases. Furthermore, the challenges associated with the clinical applicability of RA have also been discussed.

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Rosmarinic acid alleviates ethanol-induced lipid accumulation by repressing fatty acid biosynthesis

Abstract: Rosmarinic acid ameliorates ethanol-induced lipid accumulation by reducing fatty acid biosynthesis and tumor necrosis factor-α.

Cited by 23 publications

References 54 publications

Rosmarinic acid ameliorated psoriatic skin inflammation in mice through the novel inhibition of the interleukin-17A/interleukin-17A receptor interaction

Rosmarinic acid ameliorated psoriatic skin inflammation in mice through the novel inhibition of the interleukin-17A/interleukin-17A receptor interaction

Assessment of the Potential of Sarcandra glabra (Thunb.) Nakai. in Treating Ethanol-Induced Gastric Ulcer in Rats Based on Metabolomics and Network Analysis

Biomedical features and therapeutic potential of rosmarinic acid

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