Rosmarinic Acid Attenuates Cadmium-Induced Nephrotoxicity via Inhibition of Oxidative Stress, Apoptosis, Inflammation and Fibrosis

Joardar, Swarnalata; Dewanjee, Saikat; Bhowmick, Shovonlal; Dua, Tarun K.; Das, Sonjit; Saha, Achintya; Feo, Vincenzo De

doi:10.3390/ijms20082027

Cited by 97 publications

(88 citation statements)

References 64 publications

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“…[ 45 ] Among these agents is RA, which has attracted wide consideration because of its hepatorenal protective potentials against metal‐induced toxicity. [ 46 ] Rosemary extracts posses many biological activities including antimicrobial, [ 47 ] antimutagenic, [ 48 ] antihyperglycemic, [ 49 ] and antioxidant actions. [ 50,51 ] Our finding showed that RA significantly upregulated Nrf2 gene to attenuate the hepatorenal oxidative damage induced by chromium.…”

Section: Discussionmentioning

confidence: 99%

Rosmarinic acid attenuates chromium‐induced hepatic and renal oxidative damage and DNA damage in rats

Khalaf

Hassanen

Ibrahim

et al. 2020

J Biochem & Molecular Tox

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Hexavelant chromium (Cr (V1)) is a widely distributed environmental pollutant inducing damage in different organs of human and animals. The current study was designed to investigate the mechanistic role of rosmarinic acid (RA) to diminish chromium‐induced hepatorenal oxidative damage and preneoplastic lesions in rats. Plant material was collected, identified, and extracted. The isolated RA was elucidated relying on the nuclear magnetic resonance spectroscopic data. Twenty‐eight male Wistar rats received the following materials daily via oral gavage for 60 days; (Gp1): normal saline, (Gp2) 25 mg/kg.bwt RA, (Gp3) 10 mg/kg.bwt potassium dichromate (K2Cr2O7), (Gp4) K2Cr2O7 + RA. All rats were euthanized at the end of the experiment by cervical dislocation and the liver and kidney were collected. Prolonged continuous exposure of rats to chromium‐induced oxidant/antioxidant imbalance manifested by significant elevation of malondialdehyde with reduction in reduced glutathione levels. Remarkable histopathological alterations in the liver and kidney tissue sections were recorded and confirmed by overexpression of the immunohistochemical staining of caspase‐3, placental glutathione‐S transferase, proliferating cell nuclear antigen together with a significant downregulation of nuclear factor erythroid‐2 related factor 2 (Nrf2) gene and upregulation of nibrin gene. Observable improvements in the entire toxicopathological parameters were recorded in group cotreated with RA. Our findings revealed that Cr‐induced preneoplastic lesions on the liver and kidney tissues of rats when exposed daily for long period of time, as well as confirmed the ability of RA to alleviate this toxicity through upregulation of Nrf2 pathway and its powerful antioxidant effects.

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Section: Discussionmentioning

confidence: 99%

Rosmarinic acid attenuates chromium‐induced hepatic and renal oxidative damage and DNA damage in rats

Khalaf

Hassanen

Ibrahim

et al. 2020

J Biochem & Molecular Tox

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“…In this study, a notable increase in LPO and a remarkable decrease in TTM were found in the cadmium group, indicating the induction of oxidative stress in renal tissue. In this regard, renal oxidative injury induced by cadmium has been reported in several studies (8,22,23). LPO is a radical reaction that leads to the destruction of polyunsaturated fatty acids in lipid membranes and cell death (24).…”

Section: Discussionmentioning

confidence: 99%

Effects of Pistacia atlantica Subsp. Kurdica on Cadmium-Induced Oxidative Damage in Rat Kidney

Kohnepoushi

Dastan

Nili‐Ahmadabadi

2020

Avicenna J Pharm Res

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Background: Pistacia atlantica kurdica has recently been shown to possess free radical scavenging ability. The current study aims to investigate the protective effect of this plant against cadmium-induced nephrotoxicity. Methods: Thirty-six rats were divided into 6 groups (6 in each), and treated as follows: group 1 received normal saline (control group), group 2 (positive control) received cadmium by drinking water (100 mg/ L/d), group 3 received 200 mg/kg of P. atlantica extract, and groups 4-6 received cadmium as well as 50, 100 and 200 mg/kg/d of P. atlantica extract (orally), respectively. After 2 weeks, oxidative damage and renal function markers were assayed by standard methods. Results: In cadmium group, a significant increase was observed in serum blood urea nitrogen (BUN) (P<0.01) and lipid peroxidation (LPO) level of renal tissue (P<0.001) and a remarkable decrease was found in total thiol molecules (TTM) of the kidney (P<0.001). Despite the decreased renal antioxidant capacity, these changes were not significant. P. atlantica extract improved the LPO, TTM, and histopathological changes in renal tissue. Conclusion: In this study, although the P. atlantica extract did not have a significant effect on cadmiuminduced renal dysfunction, it did improve the oxidative/antioxidant balance in renal tissue.

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“…For example, rosmarinic acid small molecule mainly forms 9 hydrogen bonds with GLN-102, PRO-100, SER-99, TYR-115 and ARG-103 residues on TNF. Rosmarinic acid, which is considered one of the most important polyphenols, has several pharmacological effects: anti-oxidant, inhibition of oxidative stress, anti-inflammatory, anti-cancer and immunomodulatory [77,78]. Besides, it has been reported that rosmarinic acid may inhibit the expression of NF-κB promoter-related genes.…”

Section: Discussionmentioning

confidence: 99%

Investigating the multi-target pharmacological mechanism of danhong injection acting on unstable angina by combined network pharmacology and molecular docking

Guo

Zhou

et al. 2020

BMC Complement Med Ther

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Background: Danhong injection (DHI), which is one of the most well-known Traditional Chinese Medicine (TCM) injections, widely used to treat unstable angina (UA). However, its underlying pharmacological mechanisms need to be further clarified. Methods: In the present study, network pharmacology was adopted. Firstly, the relative compounds were obtained by a wide-scaled literatures-mining and potential targets of these compounds by target fishing were collected. Then, we built the UA target database by DisGeNET, DigSee, TTD, OMIM. Based on data, protein-protein interaction (PPI) analysis, GO and KEGG pathway enrichment analysis were performed and screen the hub targets by topology. Furthermore, evaluation of the binding potential of key targets and compounds through molecular docking. Results: The results showed that 12 ingredients of DHI and 27 putative known therapeutic targets were picked out. By systematic analysis, identified 4 hub targets (TNF, TLR4, NFKB1 and SERPINE1) mainly involved in the complex treating effects associated with coagulation and hemostasis, cell membrane region, platelet alpha granule, NFkappa B signaling pathway and TNF signaling pathway. Conclusion: The results of this study preliminarily explained the potential targets and signaling pathways of DHI in the treatment of UA, which may help to laid a good foundation for experimental research and further clinical application.

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Rosmarinic Acid Attenuates Cadmium-Induced Nephrotoxicity via Inhibition of Oxidative Stress, Apoptosis, Inflammation and Fibrosis

Cited by 97 publications

References 64 publications

Rosmarinic acid attenuates chromium‐induced hepatic and renal oxidative damage and DNA damage in rats

Rosmarinic acid attenuates chromium‐induced hepatic and renal oxidative damage and DNA damage in rats

Effects of Pistacia atlantica Subsp. Kurdica on Cadmium-Induced Oxidative Damage in Rat Kidney

Investigating the multi-target pharmacological mechanism of danhong injection acting on unstable angina by combined network pharmacology and molecular docking

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