2014
DOI: 10.1021/jf404318j
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Rosmarinic Acid Extract for Antioxidant, Antiallergic, and α-Glucosidase Inhibitory Activities, Isolated by Supramolecular Technique and Solvent Extraction from Perilla Leaves

Abstract: Rosmarinic acid extract with potent biological activities was successfully isolated by supramolecular technique and solvent extraction from Perilla leaves. By the supramolecular complex which was formed from flavocommelin and Perilla leaf extract as initial materials, the supernatant containing rosmarinic acid was isolated. Rosmarinic acid extract (62.9 ± 4.5% purity) was partly purified by partitioning ethyl acetate and water. Rosmarinic acid extract exhibited high total phenolic content of 433.9 ± 58.6 μg/mg… Show more

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Cited by 128 publications
(108 citation statements)
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“…RA possesses multiple promising biological effects including anti-cancer [24], anti-microbial, anti-allergic [25], anti-inflammatory, and anti-oxidant properties [26]. In particular, RA may be beneficial in experimental diabetes and hyperlipidemia [27].…”
Section: Introductionmentioning
confidence: 99%
“…RA possesses multiple promising biological effects including anti-cancer [24], anti-microbial, anti-allergic [25], anti-inflammatory, and anti-oxidant properties [26]. In particular, RA may be beneficial in experimental diabetes and hyperlipidemia [27].…”
Section: Introductionmentioning
confidence: 99%
“…RA is an ester of 3, 4-dihydroxyphenyllactic acid and caffeic acid [10] (Fig. 1) and possesses a wide array of biological activities such as anti-cancer [11], anti-microbial, anti-allergic [12], anti-inflammatory and neuroprotective properties [13,14]. The antioxidant efficacy of the phenolic compound is attributed to the presence of four hydroxyl groups, which makes it a potent therapeutic agent against oxidative stress [15].…”
Section: Introductionmentioning
confidence: 99%
“…Besides, RA is also potentially valuable for the improvement of diabetes mellitus and obesity by inhibiting digestive enzymes, such as α-amylase and α-glucosidase (Zhu et al, 2014). Furthermore, RA has several neuronal benefits like anti-amyotrophic lateral sclerosis (ALS) (Shimojo, Kosaka, Noda, Shimizu, & Shirasawa, 2010), anti-Alzheimer's disease (AD) (Alkam, Nitta, Mizoguchi, Itoh, & Nabeshima, 2007), improving effect on experimental Parkinson's disease model (Wang et al, 2012b), nootropic effect, and anti-depressive benefit (Ito et al, 2008;Sasaki, Han, Shimozono, Villareal, & Isoda, 2013).…”
Section: Introductionmentioning
confidence: 99%