Rosmarinic acid improves oxidative stress parameters and mitochondrial respiratory chain activity following 4-aminopyridine and picrotoxin-induced seizure in mice

Luft, Jordana Griebler; Steffens, Luiza; Morás, Ana Moira; Rosa, Mateus Strucker da; Leipnitz, Guilhian; Regner, Gabriela Gregory; Pflüger, Pricila; Gonçalves, Débora Aguirre; Moura, Dinara Jaqueline; Pereira, Patrı́cia

doi:10.1007/s00210-019-01675-6

Cited by 22 publications

(20 citation statements)

References 69 publications

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“…Thus, RA pretreatment was able to restore mitochondrial respiratory chain complex 1 activity and to reverse the other MPP positive damaging effects [91,92] partially. In mice, RA improves oxidative stress parameters and mitochondrial respiratory chain activity [108]. RA also proved to be effective in preventing in vitro amyloid peptide aggregation and in delaying disease progression in animal models [109].…”

Section: Anti-aging Activitymentioning

confidence: 94%

Therapeutic Potential of Rosmarinic Acid: A Comprehensive Review

et al. 2019

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Naturally occurring food-derived active ingredients have received huge attention for their chemopreventive and chemotherapy capabilities in several diseases. Rosmarinic acid (RA) is a caffeic acid ester and a naturally-occurring phenolic compound in a number of plants belonging to the Lamiaceae family, such as Rosmarinus officinalis (rosemary) from which it was formerly isolated. RA intervenes in carcinogenesis through different ways, including in tumor cell proliferation, apoptosis, metastasis, and inflammation. On the other hand, it also exerts powerful antimicrobial, anti-inflammatory, antioxidant and even antidepressant, anti-aging effects. The present review aims to provide an overview on anticancer activities of RA and to deliberate its therapeutic potential against a wide variety of diseases. Given the current evidence, RA may be considered as part of the daily diet in the treatment of several diseases, with pre-determined doses avoiding cytotoxicity.

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Section: Anti-aging Activitymentioning

confidence: 94%

Therapeutic Potential of Rosmarinic Acid: A Comprehensive Review

et al. 2019

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“…It involves brief episodes of involuntary movement that lead to changes in sensory perception, motor control, behavior, autonomic function, or sometimes loss of consciousness [ 1 ]. To date, despite having more than 30 antiepileptic drugs (AEDs) on the market [ 2 , 3 ], there are still difficulties in reaching the goal of treating epilepsy and its associated complications without adverse effects. Globally, epilepsy remains a public health imperative.…”

Section: Introductionmentioning

confidence: 99%

“…More than one-third of epileptic seizures are not well controlled by a single AED and often require treatment with two or more AEDs (add-on therapy) [ 1 , 2 ]. Furthermore, about 40%–60% of epileptic patients, accounting for both children and adults, develop neuropsychological impairments [ 3 ]. This drives a significant portion of epileptic patients to seek alternative interventions, particularly in herbal medicine [ 4 ].…”

Section: Introductionmentioning

confidence: 99%

Orthosiphon stamineus Proteins Alleviate Pentylenetetrazol-Induced Seizures in Zebrafish

Chung¹,

Choo²,

Ahmed³

et al. 2020

Biomedicines

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The anticonvulsive potential of proteins extracted from Orthosiphon stamineus leaves (OSLP) has never been elucidated in zebrafish (Danio rerio). This study thus aims to elucidate the anticonvulsive potential of OSLP in pentylenetetrazol (PTZ)-induced seizure model. Physical changes (seizure score and seizure onset time, behavior, locomotor) and neurotransmitter analysis were elucidated to assess the pharmacological activity. The protective mechanism of OSLP on brain was also studied using mass spectrometry-based label-free proteomic quantification (LFQ) and bioinformatics. OSLP was found to be safe up to 800 µg/kg and pre-treatment with OSLP (800 µg/kg, i.p., 30 min) decreased the frequency of convulsive activities (lower seizure score and prolonged seizure onset time), improved locomotor behaviors (reduced erratic swimming movements and bottom-dwelling habit), and lowered the excitatory neurotransmitter (glutamate). Pre-treatment with OSLP increased protein Complexin 2 (Cplx 2) expression in the zebrafish brain. Cplx2 is an important regulator in the trans-SNARE complex which is required during the vesicle priming phase in the calcium-dependent synaptic vesicle exocytosis. Findings in this study collectively suggests that OSLP could be regulating the release of neurotransmitters via calcium-dependent synaptic vesicle exocytosis mediated by the “Synaptic Vesicle Cycle” pathway. OSLP’s anticonvulsive actions could be acting differently from diazepam (DZP) and with that, it might not produce the similar cognitive insults such as DZP.

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“…Later on, RA had been identified in several species, including the members of Lamiaceae and Boraginaceae families, such as Salvia officinalis, Mentha spp, Thymus vulgaris, Melissa officinalis, Symphytum officinale, and Perilla frutescens (Fachel et al, 2019;Petersen et al, 2009). Previously, RA showed several pharmacological properties, including anti-inflammatory (K. Jiang et al, 2018), antioxidant (Luft et al, 2019), antitumor (Han, Ma, Zhao, Feng, & Zheng, 2019;Messeha, Zarmouh, Asiri, & Soliman, 2020;L. Wang, Yang, Wang, Shi, & Li, 2019), and photoprotection (Sánchez-Campillo et al, 2009).…”

mentioning

confidence: 99%

Antidepressant‐like effect of rosmarinic acid during LPS‐induced neuroinflammatory model: The potential role of cannabinoid receptors/PPAR‐γ signaling pathway

Lataliza

Assis

Laurindo

et al. 2021

Phytotherapy Research

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Rosmarinic acid (RA), an ester of caffeic acid and 3, 4-dihydroxyphenyllactic acid, has anti-inflammatory and neuroprotective activities. Herein, this study investigated in silico the drug-likeness and the potential molecular targets to RA. Moreover, it tested the antidepressant-like potential of RA in the lipopolysaccharide (LPS)-induced depression model. RA (MW = 360.31 g/mol) meets the criteria of both Lipinski's rule of five and the Ghose filter. It also attends to relevant pharmacokinetic parameters.Target prediction analysis identified RA's potential targets and biological activities, including the peroxisome proliferator-activated receptor (PPAR) and the cannabinoid receptors CB 1 and CB 2 . In vivo, RA's acute, repetitive, and therapeutic administration showed antidepressant-like effect since it significantly reduced the immobility time in the tail suspension test and increased grooming time in the splash test. Further, the pretreatment with antagonists of CB 1 , CB 2 , and PPAR-γ receptors significantly blocked the antidepressant-like effect of RA. Altogether, our findings suggest that cannabinoid receptors/PPAR-γ signaling pathways are involved with the antidepressant-like effect of RA. Moreover, this molecule meets important physicochemical and pharmacokinetic parameters that favor its bioavailability. RA constitutes a promising, innovative, and safe molecule for the pharmacotherapy of major depressive disorder.

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Rosmarinic acid improves oxidative stress parameters and mitochondrial respiratory chain activity following 4-aminopyridine and picrotoxin-induced seizure in mice

Cited by 22 publications

References 69 publications

Therapeutic Potential of Rosmarinic Acid: A Comprehensive Review

Therapeutic Potential of Rosmarinic Acid: A Comprehensive Review

Orthosiphon stamineus Proteins Alleviate Pentylenetetrazol-Induced Seizures in Zebrafish

Antidepressant‐like effect of rosmarinic acid during LPS‐induced neuroinflammatory model: The potential role of cannabinoid receptors/PPAR‐γ signaling pathway

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