Rostrocaudal Subregional Differences in the Response of Enkephalin, Dynorphin and Substance P Synthesis in Rat Nucleus Accumbens to Dopamine Depletion

Voorn, Pieter; Docter, Gerrit J.; Jongen-Rêlo, Ana L.; Jonker, Allert J.

doi:10.1111/j.1460-9568.1994.tb00291.x

Cited by 44 publications

(18 citation statements)

References 52 publications

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“…There have been no other published systematic studies of the distribution of PPD mRNA in the rat brain. However, there have been a number of studies that described the distribution PPD mRNA-synthesizing perikarya in major subdivisions or localized regions of the rat brain (Young et al, 1986;Ruda et al, 1988;AlvarezBolado et al, 1990;Meister et al, 1990;Rutherfurd and Gundlach, 1993;Griffond et al, 1994;Voorn et al, 1994). The results of these anatomically restricted studies have usually been similar to our observations.…”

Section: Distribution Of the Expression Of The Preprodynorphin Genesupporting

confidence: 88%

In situ hybridization histochemical localization of prodynorphin messenger RNA in the central nervous system of the rat

et al. 1997

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The distribution of preprodynorphin messenger RNA-containing perikarya in the central nervous system of the rat was determined with in situ hybridization histochemistry using a 35S-labelled complementary RNA probe. All of the regions of the central nervous system reported by other investigators to contain perikarya that synthesize prodynorphin-derived peptides, except the pedunculopontine tegmental nucleus, the accessory trigeminal nucleus, and the ventral nucleus of the trapezoid body, also contained perikarya that synthesize preprodynorphin messenger RNA. However, the olfactory bulb, the anterior olfactory nucleus, the islands of Calleja, the CA1-CA3 fields of the hippocampus, the septohippocampal nucleus, the diagonal band of Broca, the basal and cortical amygdaloid nuclei, the entopeduncular nucleus, the subthalamic nucleus, the superior colliculus, the Edinger-Westphal nucleus, the dentate nucleus, the raphes linearis and pontis, the dorsal cochlear nucleus, the medial vestibular nucleus, the inferior olive, and the dorsal motor nucleus of the vagus nerve also contained preprodynorphin messenger RNA-synthesizing perikarya. These observations suggest that prodynorphin-derived peptides have a much more pervasive role in central nervous system function than previously suspected. However, before the physiological significance of these observations can be judged, it will be necessary to determine whether all of the novel sites of preprodynorphin messenger RNA synthesis are sites of prohormone synthesis and conventional processing.

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Section: Distribution Of the Expression Of The Preprodynorphin Genesupporting

confidence: 88%

In situ hybridization histochemical localization of prodynorphin messenger RNA in the central nervous system of the rat

et al. 1997

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“…Conspicuous differences in the effect of cholecystokinin or dopaminergic receptor stimulation have been described between the rostral and the caudal nucleus accumbens, supporting the existence of anatomical and functional differences between these regions (Vaccarino and Rankin, 1989;Essman et al, 1993;Voorn et al, 1994). Local infusions of 5-HT into the nucleus accumbens decrease locomotor activity (Jones et al, 1981); however, it is unknown whether or not regional differences in sensitivity to serotonergic agents occur within the nucleus accumbens.…”

Section: Heterogeneous Distribution Of 5-ht 2c Receptor Mrna In the Smentioning

confidence: 97%

Pattern of expression of the serotonin2C receptor messenger RNA in the basal ganglia of adult rats

et al. 1997

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The distribution of the serotonin (5-HT) receptor 5-HT2C mRNA was examined at the single-cell level with in situ hybridization histochemistry and emulsion autoradiography in the basal ganglia and mesolimbic system of adult rats, with focus on the pallidum and the substantia nigra, which receive striatal inputs and play a critical role in basal ganglia function. 5-HT2C receptor mRNA expression was always restricted to a subpopulation of neurons in the regions examined. In the neostriatum, labeled neurons were more numerous in the rostral nucleus accumbens than in the caudal nucleus accumbens and were more numerous in the ventral and ventrolateral caudate-putamen than in the dorsal caudate-putamen, where labeled neurons were restricted to isolated clusters. In striatal target areas, dense labeling in the entopeduncular nucleus (internal pallidum, direct striatal output pathway) contrasted with an absence of labeling in the globus pallidus (external pallidum, indirect striatal output pathway). Double-label in situ hybridization in the substantia nigra revealed coexpression of 5-HT2C receptor mRNA with glutamic acid decarboxylase but not with tyrosine hydroxylase mRNA, indicating that it was restricted to gamma-aminobutyric acid (GABA)ergic neurons. In this region, dense labeling for 5-HT2C mRNA was found in half of the neurons at middle and caudal levels of both the pars compacta and the pars reticulata, with little labeling rostrally. The data suggest that drugs acting on the 5-HT2C receptor could selectively affect discrete neuronal populations in the basal ganglia and mesolimbic systems and indicate a new level of neurochemical heterogeneity among GABAergic neurons of the substantia nigra.

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“…Rostral versus caudal portions of the accumbens shell differ in cell morphology, connectivity, and neurochemical organization (Herkenham et al, 1984;Phillipson and Griffiths, 1985;Oades and Halliday, 1987;Zahm and Brog, 1992;Brog et al, 1993;Groenewegen et al, 1993;Zahm and Heimer, 1993;Voorn et al, 1994;Gorelova and Yang, 1997;Usuda et al, 1998). Although the entire shell receives afferent projections from the prefrontal cortex, subiculum, amygdala, ventral pallidum, lateral hypothalamus, ventral tegmental area, etc., the rostral shell receives denser innervation from the subiculum and basolateral amygdala, whereas the caudal shell receives sparser projections from those structures (Phillipson and Griffiths, 1985;Brog et al, 1993).…”

Section: Neurobiological Bases Of Rostrocaudal Shell Segregation Of Amentioning

confidence: 99%

Fear and Feeding in the Nucleus Accumbens Shell: Rostrocaudal Segregation of GABA-Elicited Defensive Behavior Versus Eating Behavior

2001

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This study examined localization of positive versus negative motivational functions mediated by GABA circuits within the accumbens shell. Microinjections of a GABA A agonist (0, 25, 75, and 225 ng/0.5 l muscimol) in rostral shell sites elicited appetitive increases in eating behavior. In contrast, microinjections in caudal shell sites elicited defensive burying or pawtreading behavior. Rats whose microinjections landed bilaterally outside of the accumbens shell did not display either behavior. Defensive treading elicited by caudal shell muscimol microinjection appeared to be a negative motivated response to threat (similar in parameters and orientation to normal defensive burying of a threatening electrified shock prod). The nucleus accumbens shell thus appears functionally heterogeneous in coding motivational valence. The demonstration that muscimol elicits positive eating behavior from rostral shell versus negative defensive behavior from caudal shell suggests in particular that GABAergic substrates of positive and negative types of motivated behavior in the nucleus accumbens shell are segregated along a rostrocaudal gradient.Key words: accumbens shell; GABA; food intake; reward; appetite; motivation; glutamate; dopamine; fear; defense; aggression; mesolimbic; microinjection GABAergic medium spiny neurons in the nucleus accumbens shell are implicated in the control of appetitive behavior and reward. Regarding eating behavior specifically, robust increases in food intake by rats are elicited by microinjection in the medial accumbens shell of either GABA A or GABA B receptor agonists (or non-NMDA glutamate antagonists) (Maldonado-Irizarry et al., 1995;Stratford and Kelley, 1997;Basso and Kelley, 1999).Aside from its role in positive appetitive behavior, the accumbens shell has also been implicated in negative motivational states, such as stress, fear, and defensive behavioral responses elicited by noxious or threatening stimuli (Inoue et al

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Rostrocaudal Subregional Differences in the Response of Enkephalin, Dynorphin and Substance P Synthesis in Rat Nucleus Accumbens to Dopamine Depletion

Cited by 44 publications

References 52 publications

In situ hybridization histochemical localization of prodynorphin messenger RNA in the central nervous system of the rat

In situ hybridization histochemical localization of prodynorphin messenger RNA in the central nervous system of the rat

Pattern of expression of the serotonin2C receptor messenger RNA in the basal ganglia of adult rats

Fear and Feeding in the Nucleus Accumbens Shell: Rostrocaudal Segregation of GABA-Elicited Defensive Behavior Versus Eating Behavior

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