Rotating disk sorbent extraction for pre-concentration of chromogenic organic compounds and direct determination by solid phase spectrophotometry

Richter, Pablo; Cañas, Alejandro; Muñoz, Carmen García; Leiva, Claudio; Ahumada, Inés

doi:10.1016/j.aca.2011.04.009

Cited by 40 publications

(16 citation statements)

References 24 publications

(22 reference statements)

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“…Taking into account our previous experiences in RDSE procedures, 13,14,18,19 the rotation velocity of the disk was kept at 2000 rpm, and all the optimization was made in absence of matrix modifiers. Rotation velocity was kept at the maximum velocity achieved by the magnetic stirrer, because under this condition the boundary layer formed on the surface of the sorptive phase decreases and analyte mass transfer is faster.…”

Section: Optimization Of Variablesmentioning

confidence: 99%

Determination of Triclabendazole in Cattle Plasma as Its Sulphoxide and Sulphone Metabolites by Rotating Disk Sorptive Extraction Combined With High-Performance Liquid Chromatography and Its Application to Pharmacokinetic Studies

Cañas-Müller

Campo

Richter

2016

J. Chil. Chem. Soc.

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In this study, a new method for determination of triclabendazole (TCB) as its main metabolites, triclabendazole sulfoxide (TCB-SO) and triclabendazole sulfone (TCB-SO 2 ) in animal plasma was developed. TCB is widely used as antiparasitic in the veterinary industry. Rotating disk sorptive extraction (RDSE) was the selected sample preparation technique for extraction/clean up of the compounds from the samples followed by high performance liquid chromatography coupled to diode array detection (HPLC-DAD) for quantification.Optimization of physicochemical variables was performed using a multivariate experimental design. Following the recommendations given in the Veterinary International Conference on Harmonization guides (VICH GL02 and VICH GL49), the validation of the method was performed, given rise to improved analytical features compared with those provided by other methods based on solid phase extraction (SPE). Linearity (r > 0.99) was achieved for both compounds when calibration was performed not only in standard solutions but also in animal spiked plasma. Selectivity, defined as the response ratio between blank and analyte at the limit of quantification, was 11.8% and 3.4% for TCB-SO and TCB-SO 2 , respectively. Accuracy and precision, expressed in percentage, were always lower than -16.7% and 8.1%, respectively. Eco-efficiency was quantitatively assessed indicating that the method is an excellent green method.The proposed analytical method was applied to the determination of the pharmacokinetic of two commercial products of TCB in cattle plasma after oral administration.The good analytical performance, eco-efficiency and economy, make the method interesting for alternative use in routine laboratories.

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Section: Optimization Of Variablesmentioning

confidence: 99%

Determination of Triclabendazole in Cattle Plasma as Its Sulphoxide and Sulphone Metabolites by Rotating Disk Sorptive Extraction Combined With High-Performance Liquid Chromatography and Its Application to Pharmacokinetic Studies

Cañas-Müller

Campo

Richter

2016

J. Chil. Chem. Soc.

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“…Regarding this variable, an extraction time of 30 min was sufficient to reach the partition equilibrium for sample volumes of 20 mL. Compared with the extraction of more polar analytes [13][14][15][16][17][18] , the equilibrium time for PAHs is reached faster, because these analytes have an enhanced affinity with PDMS, facilitating their extraction. This equilibrium time was also significantly lower than in previous studies using SBSE 3,4 because the surface area to phase volume ratio and the stagnant layer surface are improved under the RDSE configuration.…”

Section: Influence Of Extraction Timementioning

confidence: 99%

“…In this case, some representative PAHs were selected having low, medium and high molecular weight. The study was performed up to 3000 rpm, taking into account that the disk can be stirred at higher velocities without damaging the phase [13][14][15][16][17][18] . It can be observed that by increasing the rotational velocity the extraction efficiency of PAHs increased to reach a constant value at approximately 1250 rpm.…”

Section: Influence Of the Rotational Velocity Of The Disk On Analyte mentioning

confidence: 99%

“…In the case of the device used in SBSE, the friction of the phase with the bottom of the vessel containing the sample decreases its durability 13 . Also the RDSE can reduce solvent usage in sample preparation steps and the disk configuration is very easy to make in the laboratory [13][14][15][16][17][18] . The aim of this study was to develop a method for PAHs determination from aqueous matrices.…”

Section: Introductionmentioning

confidence: 99%

“…In our laboratory we have recently developed the technology of rotating disk sorptive extraction (RDSE), an alternative microextraction technique similar to SPME and SBSE 13 . The rotating disk extractor has the advantage of providing a greater volume of polydimethylsiloxane (PDMS) than in SPME, while also having a larger PDMS surface area than that provided by the device used in SBSE [13][14][15][16][17][18] . On the other hand, the disk can be rotated at high velocity without risk of damaging the PDMS phase, because it is only in contact with the solution, which facilitates more efficient analyte mass transfer and faster extraction 19 .…”

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Extraction of Polycyclic Aromatic Hydrocarbons From Water Samples Into a Rotating-Disk Microextractor and the Subsequent Determination by Gas Chromatography-Mass Spectrometry

Corrotea

Sánchez

Rubio

et al. 2014

J. Chil. Chem. Soc.

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The rotating disk sorptive extraction (RDSE) technique was applied in this study to the extraction of 16 polycyclic aromatic hydrocarbons (PAHs) in real water samples. The sorptive and desorptive behavior of the analytes were studied by using a rotating disk coated with polydimethylsiloxane (PDMS) on one of its surfaces. The optimal conditions for extractions of all analytes were: rotational velocity of the disk: 1250 rpm; sample volume: 20 mL; matrix modifier: 20 % MeOH and extraction time: 30 min. A desorption time of 10 min at 1250 rpm was used for the analytes using 5 mL of methanol. PAHs were measured in the extract by gas chromatography coupled to mass spectrometry (GC-MS). Under these conditions, recoveries ranging from 84 to 100 % were obtained in drinking water enriched with the analytes, and the precision, expressed as relative standard deviation, was between 2 and 20%. The detection limit of the method was between 8 and 115 ng L -1 depending on the analyte. The method was applied to the analysis of water samples obtained from a lagoon in Curauma, Chile, obtaining quantitative recoveries.

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Microextraction Techniques Based on the Combination of Agitation and Extraction in the Same Device

Roldán‐Pijuán

Lucena

Cárdenas

2015

Encyclopedia of Analytical Chemistry

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The efficiency of a given microextraction technique relies on both thermodynamic and kinetics factors. The first one defines the maximum amount of analyte that can be extracted, whereas the latter describes the rate at which the extraction equilibrium is reached. The stirring of the sample during extraction is a well‐known kinetic variable that positively affects the diffusion of the analytes between the donor and acceptor phases. Although stirring/agitation is a critical and optimizing variable in most of the microextraction techniques, only a few of them integrate stirring within the extraction device. The so‐called stirring/extraction integrated microextraction techniques present a high potential, and they have been the focus of a deep research in the past decade. This article is focused on the description of the main research milestones in this development, giving a wide overview of the potential and applicability of these microextraction techniques.

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Rotating disk sorbent extraction for pre-concentration of chromogenic organic compounds and direct determination by solid phase spectrophotometry

Cited by 40 publications

References 24 publications

Determination of Triclabendazole in Cattle Plasma as Its Sulphoxide and Sulphone Metabolites by Rotating Disk Sorptive Extraction Combined With High-Performance Liquid Chromatography and Its Application to Pharmacokinetic Studies

Determination of Triclabendazole in Cattle Plasma as Its Sulphoxide and Sulphone Metabolites by Rotating Disk Sorptive Extraction Combined With High-Performance Liquid Chromatography and Its Application to Pharmacokinetic Studies

Extraction of Polycyclic Aromatic Hydrocarbons From Water Samples Into a Rotating-Disk Microextractor and the Subsequent Determination by Gas Chromatography-Mass Spectrometry

Microextraction Techniques Based on the Combination of Agitation and Extraction in the Same Device

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