The present paper examines the impact of the Coriolis force and anisotropic Darcian porous medium on the nonsteady convective flow of bio‐nanofluid along a three‐dimensional stretchable surface. The problem has applications in extrusion processes and the geographical movement of tectonic plates under a moveable ocean. Emphasis is placed on the combined effects of anisotropic porous medium, anisotropic momentum slip and temperature, and microorganism slips at the wall. The pertaining equations are condensed to a set of similarity equations before being simulated using the Keller‐box method, an efficient numerical technique. The study reveals that the friction factor along the y‐axis decreases as the rotation parameter increases. Moreover, the heat and nanoparticle volume fraction movement gradient decrease along the y‐axis when the Darcy number and stretching rate increase. However, these rates increase with a higher velocity slip. In addition, the density of microorganisms in the bio‐nanofluid decreases when there are higher levels of unsteadiness, rotation, and Darcy numbers, as well as with increased bioconvection parameters.