Rotating night work, lifestyle factors, obesity and promoter methylation in BRCA1 and BRCA2 genes among nurses and midwives

Pepłońska, Beata; Bukowska, Agnieszka; Wieczorek, Edyta; Przybek, Monika; Zienolddiny, Shanbeh; Reszka, Edyta

doi:10.1371/journal.pone.0178792

Cited by 18 publications

(13 citation statements)

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“…To the best of our knowledge, no formal assessment for WBC BRCA2 methylation with respect to breast or ovarian cancer risk has been conducted. Notably, in a recent study using a low detection limit, Peplonska and colleagues detected evidence of WBC BRCA2 and BRCA1 methylation in 18.3% and 21.5%, respectively, among (presumably) cancer-free participants [134]. However, their estimates are unusually high, also for BRCA1 methylation.…”

Section: Normal Tissue Brca1/2 Methylation and Risk Of Breast And Ovamentioning

confidence: 99%

Constitutional Mosaic Epimutations – a hidden cause of cancer?

Lønning¹,

Eikesdal²,

Løes³

et al. 2019

CST

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Silencing of tumor suppressor genes by promoter hypermethylation is a key mechanism to facilitate cancer progression in many malignancies. While promoter hypermethylation can occur at later stages of the carcinogenesis process, constitutional methylation of key tumor suppressors may be an initiating event whereby cancer is started. Constitutional BRCA1 methylation due to cis -acting germline genetic variants is associated with a high risk of breast and ovarian cancer. However, this seems to be a rare event, restricted to a very limited number of families. In contrast, mosaic constitutional BRCA1 methylation is detected in 4-7% of newborn females without germline BRCA1 mutations. While the cause of such methylation is poorly understood, mosaic normal tissue BRCA1 methylation is associated with a 2-3 fold increased risk of high-grade serous ovarian cancer (HGSOC). As such, BRCA1 methylation may be the cause of a significant number of ovarian cancers. Given the molecular similarities between HGSOC and basal-like breast cancer, the findings with respect to HGSOC suggest that constitutional BRCA1 methylation could be a risk factor for basal-like breast cancer as well. Similar to BRCA1 , some specific germline variants in MLH1 and MSH2 are associated with promoter methylation and a high risk of colorectal cancers in rare hereditary cases of the disease. However, as many as 15% of all colorectal cancers are of the microsatellite instability (MSI) “high” subtype, in which commonly the tumors harbor MLH1 hypermethylation. Constitutional mosaic methylation of MLH1 in normal tissues has been detected but not formally evaluated as a potential risk factor for incidental colorectal cancers. However, the findings with respect to BRCA1 in breast and ovarian cancer raises the question whether mosaic MLH1 methylation is a risk factor for MSI positive colorectal cancer as well. As for MGMT , a promoter variant is associated with elevated methylation across a panel of solid cancers, and MGMT promoter methylation may contribute to an elevated cancer risk in several of these malignancies. We hypothesize that constitutional mosaic promoter methylation of crucial tumor suppressors may trigger certain types of cancer, similar to germline mutations inactivating the same particular genes. Such constitutional methylation events may be a spark to ignite cancer development, and if associated with a significant cancer risk, screening for such epigenetic alterations could be part of cancer prevention programs to reduce cancer mortality in the future.

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Section: Normal Tissue Brca1/2 Methylation and Risk Of Breast And Ovamentioning

confidence: 99%

Constitutional Mosaic Epimutations – a hidden cause of cancer?

Lønning¹,

Eikesdal²,

Løes³

et al. 2019

CST

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“…Furthermore, some studies indicate that the cancer risk of BRCA1 and BRCA2 mutation carriers might be reduced by a healthy lifestyle (e.g. no smoking, physical activity) [ 12 , 13 ].…”

Section: Introductionmentioning

confidence: 99%

Effectiveness of decision aids for female BRCA1 and BRCA2 mutation carriers: a systematic review

Krassuski

Vennedey

Stock

et al. 2019

BMC Med Inform Decis Mak

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Background Female BRCA1 and BRCA2 mutation carriers have an increased lifetime risk of developing breast and/or ovarian cancer. Hence, they face the difficult decision of choosing a preventive strategy such as risk-reducing surgeries or intensified breast screening. To help these women during their decision process, several patient decision aids (DA) were developed and evaluated in the last 15 years. Until now, there is no conclusive evidence on the effectiveness of these DA. This study aims 1) to provide the first systematic literature review about DA addressing preventive strategy decisions for female BRCA1 and BRCA2 mutation carriers, 2) to analyze the quality of the existing evidence, 3) to evaluate the effects of DA on decision and information related outcomes, on the actual choice for preventive measure and on health outcomes. Methods A systematic literature review was conducted using six electronic databases (inclusion criteria: DA addressing preventive strategies, female BRCA1 and BRCA2 mutation carriers, 18 to 75 years, knowledge of test result). The quality of the included randomized controlled trials (RCT) was evaluated with the Cochrane Collaboration’s risk of bias tool. The quality of included one-group pretest-posttest design studies was evaluated with the ROBINS-I tool. Outcomes of included studies were extracted and qualitatively summarized. Results A total of 2093 records were identified. Six studies were included for further evaluation (5 RCT, 1 one-group pretest-posttest design study). One RCT was formally included, but data presentation did not allow for further analyses. The risk of bias was high in three RCT and unclear in one RCT. The risk of bias in the one-group pretest-posttest study was serious. The outcome assessment showed that the main advantages of DA are linked to the actual decision process: Female BRCA1 and BRCA2 mutation carriers using a DA had less decisional conflict, were more likely to reach a decision and were more satisfied with their decision. Conclusions Decision aids can support female BRCA1 and BRCA2 mutation carriers during their decision process by significantly improving decision related outcomes. More high-quality evidence is needed to evaluate possible effects on information related outcomes, health outcomes and the actual choice for preventive measures. Electronic supplementary material The online version of this article (10.1186/s12911-019-0872-2) contains supplementary material, which is available to authorized users.

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“…Douglas (2014), and Wickremaratne et al (2017) found in their study that there was no significant association between colorectal cancer and shift work of nurses and midwives, Shi et al (2020) and Lieberman et al (2020), on the contrary, found in their research that the risk of cancer and colorectal cancer is higher for nurses who work night shifts, especially for those who do such work for a long time. Peplonska et al (2017) notes that the study did not show an association between night shift work and tumor markers for breast and ovarian cancer. Trossman (2015) however, writes that in some states of America nurses are encouraged to go to rest or fall asleep briefly during night work, not to struggle with their circadian rhythm and not to disturb the biological clock, to be able to plan their own schedule, train attention, recognize fatigue, control sleep, and have education on balancing work and private life.…”

Section: Methodsmentioning

confidence: 75%

Nurses’ shift work: impact on health

Dornik¹

2020

Zdravje Delovno Aktivne Populacije / Health of the Working-Age Population

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Introduction: Work is important for the survival and personal attainment of individual people, but it also affects the lifestyle of people who are in the work process and leads to various health problems that employees are facing. Shift work and night work are associated with burnout, lack of personnel and lack of control effect on burnout, personal exhaustion, long working hours are associated also with excess body weight. Quality of life, tiredness, sickness, effectiveness and overall satisfaction with the work of nurses reflects the employer 's sense for an appropriate time schedule, relaxation, psychological support and access to relaxation spaces. Methods: We used descriptive research method. We used the method of reviewing of the scientific literature based on accessibility, content relevance and actuality. We accessed it via an electronic link in the Celje Library. The restrictive criteria were the period January 2017 to April 2020, English language, availability for download, full text and scientific journals with the keywords "nurse", "shift work", "night shift" and "health" in the EBSCO and MEDLINE databases. The survey was conducted in April and May 2020. MS Word was used to display the results. Results: We have used, reviewed and processed 21 full-text articles for a review scientific article, after applying the inclusion criteria: nurse, working conditions, type of work, health link, type of publication, time period, language and availability of the full text, so 11 scientific articles are included in the final research. We found out that night work with many factors has a negative impact on the health of nurses. This is manifested as burnout, exhaustion, fatigue, depression, anxiety, concentration, chance for defects, back pain, poor eating habits, all of which have a profound effect on stress levels. The quality of sleep is also worse, the pattern of sleep is broken and insomnia increases. Discussion and conclusions: Findings show that nurses who work shifts and also do night work feel poorer quality of life, poor quality of sleep, higher

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Rotating night work, lifestyle factors, obesity and promoter methylation in BRCA1 and BRCA2 genes among nurses and midwives

Cited by 18 publications

References 91 publications

Constitutional Mosaic Epimutations – a hidden cause of cancer?

Constitutional Mosaic Epimutations – a hidden cause of cancer?

Effectiveness of decision aids for female BRCA1 and BRCA2 mutation carriers: a systematic review

Nurses’ shift work: impact on health

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