In order to explore the inducing factors and mechanism of the non-synchronous vibration, the flow field structure and its formation mechanism in the non-synchronous vibration state of a high speed turbocompressor are discussed in this paper, based on the fluid–structure interaction method. The predicted frequencies fBV (4.4EO), fAR (9.6EO) in the field have a good correspondence with the experimental data, which verify the reliability and accuracy of the numerical method. The results indicate that, under a deviation in the adjustment of inlet guide vane (IGV), the disturbances of pressure in the tip diffuse upstream and downstream, and maintain the corresponding relationship with the non-synchronous vibration frequency of the blade. An instability flow that developed at the tip region of 90% span emerged due to interactions among the incoming main flow, the axial separation backflow, and the tip leakage vortices. The separation vortices in the blade passage mixed up with the tip leakage flow reverse at the trailing edge of blade tip, presenting a spiral vortex structure which flows upstream to the leading edge of the adjacent blade. The disturbances of the spiral vortexes emerge to rotate at 54.5% of the rotor speed in the same rotating direction as a modal oscillation. The blade vibration in the turbocompressor is found to be related to the unsteadiness of the tip flow. The large pressure oscillation caused by the movement of the spiral vortex is regarded as the one of the main drivers for the non-synchronous vibration for the present turbocompressor, besides the deviation in the adjustment of IGV.