Rotational Activity around an Obstacle in 2D Cardiac Tissue in Presence of Cellular Heterogeneity

Konovalov, Pavel; Mangileva, Daria; Dokuchaev, Arsenii; Solovyova, Olga; Panfilov, Alexander V.

doi:10.3390/math9233090

Cited by 2 publications

(1 citation statement)

References 45 publications

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“…The electrical re‐entry waves in myocardial tissue were studied numerically by several research groups without a consideration for the myocardium contraction and MEF. For example, the paper 38 presents the numerical investigation of the re‐entry waves in 2D myocardium sample by the model 28 taking into account a heterogeneity of myocardial electrical properties. Conditions of different wave modes were examined numerically.…”

Section: Discussionmentioning

confidence: 99%

Effect of strain‐dependent conduction slowing on the re‐entry formation and maintenance in cardiac muscle: 2D computer simulation

Syomin

Galushka

Tsaturyan

2023

Numer Methods Biomed Eng

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The effect of mechano‐electrical feedback on re‐entry formation and maintenance was studied using a model of myocardial electromechanics that accounts for two components of myocardial conductivity and delayed strain‐dependent changes in membrane capacitance that causes a conduction slowing. Two scenarios were simulated in 2D numerical experiments: (i) propagation of an excitation–contraction wave beyond the edge of a nonconductive nonexcitable obstacle; (ii) circulation of a re‐entry wave around a nonconductive nonexcitable obstacle. The simulations demonstrated that the delayed strain‐dependent deceleration of the conduction waves promotes the detachment of the excitation‐contraction waves from the sharp edge of an elongated obstacle and modulates the re‐entry waves rotating around a compact obstacle. The data show that the mechano‐electrical feedback, together with an increase in the stimulation frequency and an increase in the excitation threshold, is an arrhythmogenic factor that must be taken into account when analyzing the possibility of the re‐entry formation.

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Section: Discussionmentioning

confidence: 99%

Effect of strain‐dependent conduction slowing on the re‐entry formation and maintenance in cardiac muscle: 2D computer simulation

Syomin

Galushka

Tsaturyan

2023

Numer Methods Biomed Eng

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Modeling the functional heterogeneity and conditions for the occurrence of microreentry in procedurally created atrial fibrous tissue

Kalinin,

Naumov,

Kovalenko

et al. 2023

Journal of Applied Physics

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The occurrence of atrial fibrillation (AF), one of the most socially significant arrhythmias, is associated with the presence of areas of fibrosis. Fibrosis introduces conduction heterogeneity into the cardiac tissue and, thus, may be a substrate for spiral wave reentry, which provokes the onset of AF and is often associated with its persistence. Despite results from computer and animal models of cardiac tissues, data on the conditions under which microreentries occur in human tissues are limited. In this work, we conducted a study of the new approach to modeling the fibrous atrial tissue, which takes into account the cellular structure and conduction in fibrosis areas. Using the Potts model, we created a realistic texture of atrial tissues remodeled by fibroblasts and showed the presence of pathways in such a system with a low proportion of fibroblasts. Our study revealed the relationship between the shape of the cells’ action potential, their location in the tissue, and the direction of the wave propagation. The wavefront obtained in the model creates a dynamic heterogeneity of the tissue, which affects the migration and pinning of spiral waves, and explains the formation of microreentries in the cardiac tissue. In the future, such a model can become a potential tool for predictive modeling of AF and the search for ablation target identification.

show abstract

Rotational Activity around an Obstacle in 2D Cardiac Tissue in Presence of Cellular Heterogeneity

Cited by 2 publications

References 45 publications

Effect of strain‐dependent conduction slowing on the re‐entry formation and maintenance in cardiac muscle: 2D computer simulation

Effect of strain‐dependent conduction slowing on the re‐entry formation and maintenance in cardiac muscle: 2D computer simulation

Modeling the functional heterogeneity and conditions for the occurrence of microreentry in procedurally created atrial fibrous tissue

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