Rotational behavior induced in rats by intranigral application of GABA-related drugs and GABA antagonists

Olpe, Hans‐Rudolf; Schellenberg, H.; Koella, Werner P.

doi:10.1016/0014-2999(77)90012-7

Cited by 115 publications

(21 citation statements)

References 7 publications

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“…In contrast to the behavior obtained with muscimol in STN, muscimol (200 or 45 pmol) injected into the center of SNpr resulted in a high rate of contralaterally directed circling in both the presence and absence of tail lift stimulation (Table 1 ; Fig. 3); this effect confirms well established findings (Oberlander et al, 1977;Olpe et al, 1977;Scheel-Kruger et al, 1977;Olianas et al, 1978;Waddington, 1978a;Kozlowski and Marshall, 1980;Childs and Gale, 1984). Similarly, in agreement with previous studies that have shown contralaterally directed circling with the injection of glutamate antagonists into SNpr (Dawbarn and Pycock, 1981;St-Pierre and Bedard, 1994;Murer et al, 1996), kynurenate injected into the center of the SNpr induced a high rate of contralaterally directed circling both in the presence and absence of tail lift stimulation (Table 1).…”

Section: Postural Effectssupporting

confidence: 58%

“…Unilateral intranigral microinjection of GABA A agonists (Oberlander et al, 1977;Olpe et al, 1977;Scheel-Kruger et al, 1977;Olianas et al, 1978;Waddington, 1978a,b; Kozlowski and Marshall, 1980;; Childs and Gale, 1984) or glutamate antagonists (Dawbarn and Pycock, 1981;St-Pierre and Bedard, 1994;Murer et al, 1996) results in locomotor activation, contralaterally directed circling, and postural asymmetry. Bilateral intranigral application of GABA A agonists induces stereotyped hyperactivity (sniffing and gnawing; Scheel-Kruger et al, 1977;Childs and Gale, 1983;Baumeister and Frye, 1984).…”

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confidence: 99%

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Postural and Anticonvulsant Effects of Inhibition of the Rat Subthalamic Nucleus

2000

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The subthalamic nucleus (STN) plays a crucial role as a regulator of basal ganglia outflow by providing excitatory glutamatergic input into the two output nuclei of the basal ganglia, substantia nigra pars reticulata (SNpr), and entopeduncular nucleus. This study examined the effects of suppressing activity in the STN of the awake, behaving rat. Specifically, we evaluated the effects of unilateral and bilateral focal inhibition of STN on posture, locomotion, and susceptibility to limbic motor seizures.Unilateral microinjection of a GABA A receptor agonist (muscimol, 200 pmol) into STN produced a site-dependent contralaterally directed postural asymmetry without locomotor activation. This effect differed from responses produced by the same dose of muscimol placed into SNpr, which included locomotor activation in addition to contralaterally directed postural asymmetry. Locomotor activation and postural asymmetry were obtained also after blockade of glutamate transmission in SNpr by the unilateral application of kynurenate (100 nmol). Our observation that STN inhibition did not induce the locomotor activation characteristic of SNpr inhibition suggests that there are glutamatergic inputs to SNpr, other than those from STN, that are responsible for controlling locomotion.Bilateral, but not unilateral, injection of muscimol (200 pmol) into STN protected against limbic motor seizures evoked either by intravenous bicuculline or by focal application of bicuculline into anterior piriform cortex (area tempestas). These results demonstrate that focal inhibition of STN reproduces the postural asymmetry and anticonvulsant actions that are obtained with the inhibition of SNpr. This provides behavioral support for the concept that STN contributes a crucial tonic excitatory (glutamatergic) drive to the rat SNpr.

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Section: Postural Effectssupporting

confidence: 58%

mentioning

confidence: 99%

Postural and Anticonvulsant Effects of Inhibition of the Rat Subthalamic Nucleus

2000

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“…Circling is a common feature in animals with an imbalance between the basal ganglia outputs in the two hemispheres (Oberlander et al, 1977;Olpe et al, 1977, Scheel-Kruger et al, 1977Hikosaka and Wurtz, 1983a-c;Sirinathsinghji, 1985;Bankiewicz et al, 1986). For instance, localized inactivation of the medial SNr induces contraversive turning, which has been attributed to abnormalities of the nigro-collicular projection (Hikosaka and Fig.…”

Section: Circling and Other Behavioral Disturbancesmentioning

confidence: 99%

Effects of Transient Focal Inactivation of the Basal Ganglia in Parkinsonian Primates

Baron

Wichmann²,

Ma³

et al. 2002

J. Neurosci.

124

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Ablative and chronic stimulation procedures targeting the internal pallidum (GPi) and the subthalamic nucleus (STN) have led to major advancements in the treatment of Parkinson's disease and other movement disorders. Although these procedures have evolved to primarily target the posterior ventrolateral sensorimotor portion of GPi and to less selectively target STN, centrally, the ideal targets within these structures remain to be fully established. In this study, we sought to identify the optimal targeting sites in GPi and STN for reversal of parkinsonian signs through a series of reversible injections of the GABA A agonist muscimol in these nuclei in parkinsonian primates.Akinesia and bradykinesia were strongly ameliorated by discrete inactivation within the centromedial extent of the sensorimotor territory in GPi and the lateral portion of the sensorimotor territory in STN. This suggests that akinesia and bradykinesia might, in fact, originate from abnormalities in the same, or at least overlapping, motor circuits in the parkinsonian state. Inactivation of areas outside of the motor territories did not improve parkinsonism but induced circling and behavioral abnormalities. The segregation of basal ganglia-thalamocortical circuits appears to be therefore maintained, at least to a large extent, in the parkinsonian state.These results underscore that inactivation of discrete regions in the central territory of GPi and the lateral portion of STN are sufficient to ameliorate parkinsonian motor signs and that extension of lesions into nonmotor territories may be deleterious. Surgical outcomes might therefore be optimized by placing more discrete lesions and by restricting the extent of chronic stimulation.

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“…The principal method for the study of their possible roles is the focal injection of GABA or GABA agonists in animal behavioural models. In certain such tests baclofen and 4-hydroxybutyrate, like muscimol, reproduce the effect of focal GABA injection (Olpe et al 1977). In man, GABA agonists and GABA-mimetics have been administered orally in a variety of experimental studies (see Table 1).…”

Section: Pharmacological Studiesmentioning

confidence: 99%

GABA and acute psychoses

Meldrum¹

1982

Psychol. Med.

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Rotational behavior induced in rats by intranigral application of GABA-related drugs and GABA antagonists

Cited by 115 publications

References 7 publications

Postural and Anticonvulsant Effects of Inhibition of the Rat Subthalamic Nucleus

Postural and Anticonvulsant Effects of Inhibition of the Rat Subthalamic Nucleus

Effects of Transient Focal Inactivation of the Basal Ganglia in Parkinsonian Primates

GABA and acute psychoses

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