Syndesmotic ankle sprains, i.e. injuries to the distal tibiofibular syndesmosis, are debilitating injuries often associated with arduous rehabilitation and recovery. External foot rotation, induced by internal rotation of the tibia, is hypothesized as the primary mechanism of these injuries, but the role of ankle flexion remains poorly understood for both injury patterns and tolerances. Furthermore, clinical observations include combinations of ligament and osseous injuries, with unclear links between causation and injury patterns.