Rotator Cuff Repair Using an Acellular Dermal Matrix Graft: An In Vivo Study in a Canine Model

Rotator Cuff Repair Augmentation in a Canine Model with Use of a Woven Poly-L-Lactide Device

“…Studies in which devices were investigated for repair augmentation (i.e., the device was applied over the primary tendon-bone repair) 28,33,64 are more appropriate for comparison with our work than are studies in which devices were investigated as interpositional scaffolds to replace a resected tendon 26,[29][30][31]34,36,37 . Schlegel et al performed full-width infraspinatus injury and repair in sheep 33 .…”

“…Experimental Design E ight adult, male mongrel dogs (25 to 30 kg) underwent bilateral shoulder surgery 30,31 as approved by the Institutional Animal Care and Use Committee at our institution. Both shoulders received the same tendon injury: partial release of the superior 8 to 9 mm of the infraspinatus tendon, which constitutes approximately two-thirds of the full tendon width.…”

“…To address these challenges, natural and synthetic devices have been investigated for the reinforcement of rotator cuff repairs. Rotator cuff repair with devices derived from polylactic acid [26][27][28] , polytetrafluoroethylene 29 , extracellular matrix [30][31][32][33][34][35] , chitin 36 , and chitosanhyaluronan 37 have been studied in animal models over the past decade. Of these, only extracellular matrix derived from dermis, small intestine submucosa, fascia lata, and pericardium are commercially available for rotator cuff repair at the current time 38 .…”

Does Augmentation with a Reinforced Fascia Patch Improve Rotator Cuff Repair Outcomes?

“…Similarly, noncrosslinked biologic scaffolds derived from dermis [2] and SIS [12,32] and synthetic scaffolds derived from PLLA [17] have shown a biocompatible host response at 12 weeks in large-animal rotator cuff models. A thorough histologic survey of these augmented repair constructs from the bone to the medial tendon attachment of the patch has not been previously performed and would allow investigation of region-specific cellular infiltration and vascularization, patch integration, and patch resorption.…”

Strategies in Biologic Augmentation of Rotator Cuff Repair: A Review

“…In the repair site, an extracellular matrix with no cellular components acts as a tissue bridge between shortened tendon and bone, and its matrix can act as an effective scaffold for aligned cellular growth and collagen assembly [1]. These augmentations are currently available in three forms: xenograft, allograft, and synthetic extracellular matrices.…”