Rotator cuff repair with biodegradable high-purity magnesium suture anchor in sheep model

Chen, Yudie; Sun, Yu; Wu, Xuli; Lou, Jie; Zhang, Xiaonong; Peng, Zhaoxiang

doi:10.1016/j.jot.2022.07.008

Cited by 9 publications

(8 citation statements)

References 50 publications

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“…Magnesium suture anchors have entered the stage of animal experiment. The researchers used 99.98% high purity magnesium suture anchors to repair sheep's infraspinatus tendon in sheep, and histological examination 12 weeks after surgery revealed good tendon-bone healing, no local inflammatory reaction, and no toxic damage to organs, during which the anchors maintained reliable strength [ 131 ]. Some scholars tried to use Magnezix ® magnesium alloy screws in Latarjet procedure for shoulder instability, but biomechanical studies on cadaveric bones have found that the screws have a risk of breakage [ 132 ].…”

Section: Application Of Absorbable Biomaterials In Sport Medicine Pro...mentioning

confidence: 99%

Absorbable implants in sport medicine and arthroscopic surgery: A narrative review of recent development

Huang,

Yang,

Kou

et al. 2024

Bioactive Materials

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Section: Application Of Absorbable Biomaterials In Sport Medicine Pro...mentioning

confidence: 99%

Absorbable implants in sport medicine and arthroscopic surgery: A narrative review of recent development

Huang,

Yang,

Kou

et al. 2024

Bioactive Materials

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“…Metallic alloys can be gradually corroded in vivo , but the biodegradability of them depends on the ratio of different ingredients which has been the focus of recent studies about alloys. Mg is biocompatible with rather low cytotoxicity which can release Mg 2+ and hydrogen for therapeutic effects, including enhancing angiogenesis and regulating an inflammatory reaction. , In particular, the in vivo biodegradability of Mg alloys avoids surgical intervention for removing implants. − Unfortunately, the excessive corrosion rate of pure Mg alloys would contribute to hydrogen accumulation and decreased mechanical integrity which restricts their physiological application. , The addition of coating, other alloy elements, and rare-earth elements have been testified as practical solutions for realizing controlled corrosion rate and enhanced mechanical strength of Mg alloys. Hou et al fabricated a MgZnCa alloy, within which 0.7 wt % zinc (Zn) was used for enhanced mechanical strength and 0.6 wt % calcium (Ca) was incorporated for increased castability (Figure a).…”

Section: Bone Regenerative Fixationmentioning

confidence: 99%

“… 53 , 54 In particular, the in vivo biodegradability of Mg alloys avoids surgical intervention for removing implants. 55 − 58 Unfortunately, the excessive corrosion rate of pure Mg alloys would contribute to hydrogen accumulation and decreased mechanical integrity which restricts their physiological application. 55 , 59 The addition of coating, 60 other alloy elements, and rare-earth elements have been testified as practical solutions for realizing controlled corrosion rate and enhanced mechanical strength of Mg alloys.…”

Section: Bone Regenerative Fixationmentioning

confidence: 99%

Biodegradable Implants for Internal Fixation of Fractures and Accelerated Bone Regeneration

et al. 2023

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Bone fractures have always been a burden to patients due to their common occurrence and severe complications. Traditionally, operative treatments have been widely used in the clinic for implanting, despite the fact that they can only achieve bone fixation with limited stability and pose no effect on promoting tissue growth. In addition, the nondegradable implants usually need a secondary surgery for implant removal, otherwise they may block the regeneration of bones resulting in bone nonunion. To overcome the low degradability of implants and avoid multiple surgeries, tissue engineers have investigated various biodegradable materials for bone regeneration, whereas the significance of stability of long-term bone fixation tends to be neglected during this process. Combining the traditional orthopedic implantation surgeries and emerging tissue engineering, we believe that both bone fixation and bone regeneration are indispensable factors for a successful bone repair. Herein, we define such a novel idea as bone regenerative fixation (BRF), which should be the main future development trend of biodegradable materials.

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“…Ma et al [2] reported that the ZE21C suture anchor promoted bone healing above the suture anchor and regeneration of the fibrocartilage interface of the ligament-bone junction. Chen et al [15] developed a high-purity Mg suture anchor for sheep rotator cuff repair that provided reliable anchoring function within 12 weeks with no toxic effects on animal organs. It is well accepted that the structure design determines the performance of a biodegradable suture anchor by means of affecting its corrosion behaviors and mechanical properties [16][17][18].…”

Section: Introductionmentioning

confidence: 99%

Mechanical Properties and In Vitro Corrosion Behaviors of Biodegradable Magnesium Alloy Suture Anchors

Mao,

Dai,

Cai

et al. 2024

Metals

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Biodegradable suture anchors based on Mg-Nd-Zn-Zr alloy were developed for ligament-to-bone fixation in rotator cuff surgeries. The Mg alloy anchors were designed with structural features of narrow tooth and wide tooth, and simulated through finite element analysis (FEA). Meanwhile, the corrosion behaviors of the Mg alloy anchors were studied by immersion test and the mechanical properties were investigated by measuring the maximum torque and pull-out force. The simulation result showed that the wide-tooth anchor exhibited more a uniform stress distribution and lower shear stress in the torsion process, suggesting a satisfactory torsional resistance of this structure. Meanwhile, the wide-tooth anchor exhibited a lower Von-Mises stress after applying the same pull-out force in the simulation, indicating a higher resistance to pull-out failure of the anchor. The result of the immersion test indicated that the wide-tooth anchor exhibited a slightly slower corrosion rate in Hank’s solution after 14-day immersion, which was beneficial to enhance the structural and mechanical stability of the biodegradable suture anchor. Furthermore, the results of the mechanical properties test demonstrated that the wide-tooth anchor showed superior performance with higher maximum torques and axial pull-out forces before and after corrosion. More importantly, the axial pull-out force and maximum torque for the wide-tooth anchor decreased by 5.86% and 8.64% after corrosion, which were significantly less than those for the narrow-tooth anchor. Therefore, the wide-tooth suture anchor with lower corrosion rate, higher mechanical properties and structural stability is a promising candidate for ligament-bone fixation in the repair of rotator cuff injuries.

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Rotator cuff repair with biodegradable high-purity magnesium suture anchor in sheep model

Cited by 9 publications

References 50 publications

Absorbable implants in sport medicine and arthroscopic surgery: A narrative review of recent development

Absorbable implants in sport medicine and arthroscopic surgery: A narrative review of recent development

Biodegradable Implants for Internal Fixation of Fractures and Accelerated Bone Regeneration

Mechanical Properties and In Vitro Corrosion Behaviors of Biodegradable Magnesium Alloy Suture Anchors

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