Rotavirus and adenovirus frequency among patients with acute gastroenteritis and their relationship to clinical parameters: a retrospective study in Turkey

Abstract

BackgroundDiarrhea is the third leading cause of death related to infectious diseases all over the world. The diseases related to viral gastroenteritis are gradually increasing, particularly in the developed countries. The purpose of our study was to determine the frequency and to investigate the clinical manifestations of acute rotavirus and adenovirus gatroenteritis and to assess the diagnostic value of the related clinical findings.MethodsIn 2007-2008 patients with diarrhea and/or vomiting attended to Yeditepe University Hospital and related clinics, Istanbul, were studied. The rotavirus and/or adenovirus antigen in stool of these patients were investigated. Data regarding clinical findings were collected from the electronic records, retrospectively. Age, gender, symptoms, fever, antibiotic use, vomiting, number of vomiting and diarrhaeae, dehydration, abdominal pain, the other pathological physical examination findings were analyzed by the physicians in the study group. To investigate the rotavirus and adenovirus antigen CerTest Rota-Adeno Blister Test (CerTest, Biotec, Spain), a qualitative immunochromotographic assay was used. Statistical analysis wasperformed with SPSS v. 11,5 statistical software. X2 test was used for bivariate and logistic regression analysis was used for multivariate analysis.ResultsRotavirus positivity was 18,7% (n = 126). Concomitantly, in 596 cases adenovirus antigen test were also performed. Adenovirus positivity was 8,9% (n = 53) and rota-adenovirus co-infection was 4,4% (n = 26). Most of rotavirus positive cases were seen in December, January, February and March (p < 0.001). In clinical parameters, there was a significant difference between rotavirus positive cases and negative cases regarding to vomiting, dehydration and vomiting and diarrhea coexistence (respectively p = 0.010, p < 0.00, p = 0.007).ConclusionRotavirus can be seen in all age groups, but more frequently in childhood. Although there is no clinical gold standard to distinguish the rotavirus cases from the other gastroenteritis agents, the findings of dehydration and vomiting-diarrhea coexistence, considering months of referral may lead clinician to perform rapid antigen tests and affect approach to the treatment. Prospective studies with representative samples are needed to determine the rotavirus and adenovirus incidence and to develop safe and reliable protective policies in our country.

Investigation of Rotavirus Frequency and Following up the Rotavirus Season among Children with Acute Gastroenteritis: Evaluation of Five-year Results

“…(16) 'nın Mersin'de, 2007-2008 yılları arasında Akan ve ark. (1) 'nın İstanbul'da, 2004-2005 yılları arasında Topkaya ve ark. (21) 'nın İstanbul'da ve 2000-2001 yılları arasında Kurugöl ve ark.…”

“…Çalışma-mızda, genel olarak ülkemizde yapılan diğer çalışmalarla uyumlu olarak erkek ve kız çocuk-larda antijen pozitifliği açısından istatistiksel olarak anlamlı bir fark bulunmamıştır (p>0.05) (1,3,11,16,20) . Rotavirus infeksiyonlarının mortalite ve morbiditesini azaltmak amacıyla geliştirilen, 2006 ve 2008 yıllarında Amerikan Gıda ve İlaç Dairesi (FDA) onayı alan iki rotavirus aşısı bir çok ülkede çocukluk çağı aşı programlarına dahil edilmiştir.…”

Investigation of Seven Different RNA Viruses Associated with Gastroenteritis in Children Under Five Years Old

“…Bizim çalışmamızda elde edilen toplam pozitiflik oranı (%38.7), bu araştırıcıların 9 sonucuna (%42.9) yakın olmasına karşın, viral etkenlerin sıklık derecelerinde farklılık gözlenmiş ve ilk sırayı noroviruslar (6 GII+2 GI; 8/31, %25.8) alırken onu rotavirus grup A (2/31, %6.5) izlemiştir. Ülkemizde son yıllarda yapılan çalışmalar değerlendirildiğinde ise, gastroenteritli çocuklarda rotavirus pozitiflik oranlarının (çoğu antijen testleri ile alınan sonuçlar olmak üzere) %18-53 arasında olduğu görülmektedir [21][22][23][24][25][26][27][28] . Bizim çalış-mamızda rotavirus saptanma oranının (%6.5) bu çalışmalardan daha düşük bulunması, kullanılan yöntemlerin farklılığından ve bölgesel farklılıklardan kaynaklanmış olabilir.…”

Frequency of Rotavirus and Adenovirus in Children with Diarrhea in Sivas Numune Hospital

“…The methods used in the studies carried out in our country and the rotavirus, adenovirus positivity percentages are given in the following table (Table 3). Rotavirus positivity ranges between 9.7% and 36.1%, adenovirus positivity ranges between 1.06% and 9.3% [9][10][11][12][13][14][15][16][17] . The rotavirus positivity ratio in all age groups was detected as 11.3% in this study.…”