Rotavirus Disease in Finnish Children: Use of Numerical Scores for Clinical Severity of Diarrhoeal Episodes

Ruuska, Tarja; Vesikari, Timo

doi:10.3109/00365549009027046

Cited by 641 publications

(453 citation statements)

References 20 publications

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“…The severity of norovirus and rotavirus gastroenteritis excluded mixed infections and was evaluated on three criteria, the severity score defined by Vesikari [13], the need for intravenous rehydration and the length of the hospitalization. In the population of children studied, norovirus infections were significantly less severe than rotavirus infections.…”

Section: Discussionmentioning

confidence: 99%

“…Each episode was graded using the 20-point severity score scale [13,14]. Furthermore, the occurrence of bloody diarrhoea, the use of intravenous rehydration and the length of hospitalization were documented.…”

Section: Methodsmentioning

confidence: 99%

“…The sex ratio was 1.26. The mean Vesikari score was 11.7 (standard deviation, 3.16; range, [4][5][6][7][8][9][10][11][12][13][14][15][16][17][18][19]. Among the 95 sets of data rejected in this study, 13 were rejected for the lack of clinical data and 82 for the absence of a faecal sample.…”

Section: Study Population and General Screeningmentioning

confidence: 99%

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Epidemiology and clinical features of gastroenteritis in hospitalised children: prospective survey during a 2-year period in a Parisian hospital, France

Lorrot

Bon

Hajje

et al. 2010

Eur J Clin Microbiol Infect Dis

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International audienceRotavirus is recognised as the most important agent of severe acute gastroenteritis (AGE) in young children. In a 2-year prospective survey, we investigated the epidemiology and clinical features of the viral and bacterial pathogens in children hospitalised for AGE. The study was performed in a Parisian teaching hospital from November 2001 to May 2004. Clinical data were prospectively collected to assess the gastroenteritis severity (20-point Vesikari severity score, the need for intravenous rehydration, duration of hospitalisation). Stools were systematically tested for group A rotavirus, norovirus, astrovirus and adenovirus 40/41, sapovirus and Aichi virus and enteropathogenic bacteria. A total of 457 children (mean age 15.9 months) were enrolled. Viruses were detected in 305 cases (66.7%) and bacteria in 31 cases (6.8%). Rotaviruses were the most frequent pathogen (48.8%), followed by noroviruses (8.3%) and adenoviruses, astroviruses, Aichi viruses and sapoviruses in 3.5%, 1.5%, 0.9% and 0.4%, respectively. Cases of rotavirus gastroenteritis were significantly more severe than those of norovirus with respect to the Vesikari score, duration of hospitalisation and the need for intravenous rehydration. Rotaviruses were the most frequent and most severe cause in children hospitalised for AGE, and noroviruses also account for a large number of cases in this population

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Section: Discussionmentioning

confidence: 99%

Section: Methodsmentioning

confidence: 99%

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Epidemiology and clinical features of gastroenteritis in hospitalised children: prospective survey during a 2-year period in a Parisian hospital, France

Lorrot

Bon

Hajje

et al. 2010

Eur J Clin Microbiol Infect Dis

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“…If the parent indicated that the child had diarrhoea, the interviewer collected information regarding the date of the episode and clinical presentation. The severity of the diarrhoea episodes was classified following Ruuska and Vesikari score (Ruuska & Vesikari 1990), as modified by Nakagomi et al (2005). Episodes with scores e�ual to or above 12 were classified as severe and analysed according to age categories to control for the age differences in vaccinated and unvaccinated children.…”

Section: Patients Materials and Methodsmentioning

confidence: 99%

Acute diarrhoea in a community cohort of children who received an oral rotavirus vaccine in Northeast Brazil

Vieira

Gurgel

Kirby

et al. 2011

Mem. Inst. Oswaldo Cruz

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Rotavirus is an important cause of childhood diarrhoea. A monovalent rotavirus vaccine (Rotarix ® ) was introduced into the Immunization Program of Brazil in 2006. In this study, we describe the incidence and burden of disease of rotavirus diarrhoea in two cohorts of children (vaccinated and unvaccinated). We followed two groups of 250 children under one year old, who were enrolled in December 2006 from a low-income residential area inNortheast Brazil. The children were monitored every two weeks for two years. Stool samples from children with diarrhoea were examined for the presence of rotavirus. Rotaviruses were genotyped using real time-polymerase chain reaction. The mean numbers of all-cause diarrhoea episodes/child (adjusted for age) in the first year were 0. 87 and 0.84, in vaccinated and unvaccinated children, respectively. During the second year, the number of episodes/ child decreased to 0.52 and 0.42. Only 16 (4.9%) of 330 stool samples were rotavirus-positive (10 vaccinated and 6 unvaccinated children) and only P[4]G2 rotaviruses were identified. All-cause diarrhoea episodes were more severe in unvaccinated children in the first year of age (p < 0.05), while vaccinated children had more severe episodes 18 months after vaccination. Rotavirus diarrhoea incidence was very low in both groups. Key words: diarrhoea -rotavirus -vaccine -cohort -children -BrazilRotavirus diarrhoea in vaccinated children • Sarah Cristina Fontes Vieira et al. 331ties were visited at home in 2006 and their parents were invited to enrol their children in the study, independent of their vaccination status. The parents of the first 250 children who had received two oral doses of the Rotarix ® vaccine (GlaxoSmithKline Biologicals, Rixensart, Belgium) at two and four months of age (vaccinated cohort) were invited to participate and a further 250 children who had not received the vaccine comprised the unvaccinated cohort. Vaccination status was verified using the child's vaccination card and the Health Centre's databases. The youngest unvaccinated children registered were selected, despite the fact that the two groups could not be matched by age, as unvaccinated children had to be ineligible for vaccination at the time of enrolment, and therefore at least four months of age. Unvaccinated children serving as the control group were not offered the vaccine due to EPI guidelines that exclude children greater than or e�ual to four months of age to avoid the risk of intussusception among older infants (WHO 2007).After obtaining informed parental consent, all children were visited at home for the following two years, independently of their age at the time of enrolment. Visits were conducted every two weeks by three trained interviewers who in�uired as to whether or not the child had experienced diarrhoea episodes during the previous twoweek period. If the parent indicated that the child had diarrhoea, the interviewer collected information regarding the date of the episode and clinical presentation. The severity of the diarrhoea episodes wa...

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“…[15][16][17] Otra posible explicación del gasto fecal alto es la etiología de la diarrea; los Rotavirus y el V. Cholerae, por ejemplo, ocasionan diarreas de gasto fecal elevado. 18,19 Sin embargo, en el presente estudio no se incluyeron casos de cólera y la frecuencia de rotavirus fue semejante en ambos grupos.…”

Section: Discussionunclassified

Hidratación oral continua o a dosis fraccionadas en niños deshidratados por diarrea aguda

et al. 2002

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Rotavirus Disease in Finnish Children: Use of Numerical Scores for Clinical Severity of Diarrhoeal Episodes

Cited by 641 publications

References 20 publications

Epidemiology and clinical features of gastroenteritis in hospitalised children: prospective survey during a 2-year period in a Parisian hospital, France

Epidemiology and clinical features of gastroenteritis in hospitalised children: prospective survey during a 2-year period in a Parisian hospital, France

Acute diarrhoea in a community cohort of children who received an oral rotavirus vaccine in Northeast Brazil

Hidratación oral continua o a dosis fraccionadas en niños deshidratados por diarrea aguda

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