Rotavirus epidemiology and surveillance before vaccine introduction in Argentina, 2012–2014

Degiuseppe, Juan Ignacio; Reale, E.A.; Stupka, Juan Andrés

doi:10.1002/jmv.24650

Cited by 15 publications

(16 citation statements)

References 32 publications

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“…Seasonal fluctuations in rotavirus infection are documented, with an increase of the viral activity in cold and dry months (6,(13)(14)(15)(16)(17). However, in accordance with other studies that describe RV as circulating throughout the year (6,18,19), in our study, the presence of RV was demonstrated during the four seasons of the 3 years sampled, with a decrease in the frequency of detection in the spring.…”

Section: Discussionsupporting

confidence: 90%

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Enteric Viruses in Surface Waters from Argentina: Molecular and Viable-Virus Detection

Masachessi

Pisano

Prez

et al. 2018

Appl Environ Microbiol

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Water resources contaminated with wastewater are an important source for the dissemination of enteric viruses with an impact on the health of the population. The aim of the study was to assess the viral contamination of freshwater from a dam in Argentina by using infectious enterovirus detection, viral RNA amplification, and a genetic characterization of five enteric viruses associated with diarrhea and hepatitis. Enterovirus infectivity (iEV) was evaluated by cell culture and direct immunofluorescence. The detection of the viral genome of rotavirus (RV), human astrovirus (HAstV), norovirus (NoV), hepatitis A virus (HAV), and hepatitis E virus (HEV) was performed by reverse transcriptase PCR (RT-PCR). A total of 48 water samples from 4 monitoring points on the body of the dam from January to December 2012 and 66 water samples from 3 tourist beaches on the edge of the dam from October 2013 to October 2015 were collected monthly. During the first period, the overall viral frequency detection was 52.1% for group A RV, 50% for HAstV, 60.4% for NoV, 22.9% for HAV, 2.1% for HEV, and 64.6% for iEV. The overall frequency detection for the second sampling was 18.2% for RV and HAstV, 31.8% for NoV, 7.57% for HEV, and 66.7% for iEV. There was no detection of HAV during this period. The genotypes and genogroups detected through the study correlated with the most common genomic variants associated with human gastrointestinal and hepatitis illnesses. The results obtained could alert the health systems and environmental sanitation to make decisions for viral control and prevention in our environment. The study shows the impact of anthropic contamination of one of the most important tourist water resources in Argentina. This course of recreational water would be a favorable scenario for infection, as well as a reservoir for the enteric viruses, creating a risk for the population exposed to these waters. The results obtained could alert the health systems and environmental sanitation to make decisions for the control and prevention of viral diseases in this environment.

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Section: Discussionsupporting

confidence: 90%

“…It is estimated that RV causes more than approximately 600,000 deaths annually in children all over the world. In Argentina, it is responsible for 40% of hospital admissions of acute diarrhea, and it is estimated that this virus may cause between 30 and 50 deaths annually in the country (13).…”

Section: Discussionmentioning

confidence: 99%

Enteric Viruses in Surface Waters from Argentina: Molecular and Viable-Virus Detection

Masachessi

Pisano

Prez

et al. 2018

Appl Environ Microbiol

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“…Analyses of the Argentinean G3P[6]-2011 genes showed that despite presenting a typical Genotype 2 constellation, all of them clustered distantly from the prototype strain DS1 (G2P[4]); and more closely related to the G3P[6] and G2P[6] strains recently detected in Belgium and USA [19] – [20] , respectively ( Fig. 1 ).…”

Section: Resultsmentioning

confidence: 99%

“…In Latin America, G3P[8] has been barely detected (i.e. <0.5%) [43] – [44] until recently, when >39% of the rotavirus strains circulating in Argentina during 2008–2010 presented this G and P combination [18] – [19] .…”

Section: Discussionmentioning

confidence: 99%

“…In 2008, an increased frequency of detection of G3P[8] strains was observed reaching up to 54.1% of the strains analyzed in 2009 [18] . Interestingly, in 2011 the genotype G3P[6] was first detected in Argentina in 37 samples (6.3%) [19] . This finding coincided with the recent detection of G3P[6] and G2P[6] strains in Brazil and Belgium [20] – [21] .…”

Section: Introductionmentioning

confidence: 99%

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Genetic Diversity of G3 Rotavirus Strains Circulating in Argentina during 1998–2012 Assessed by Full Genome Analyses

2014

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Seasonal shifts in the predominant strains and the periodic emergence of new strains are epidemiological features of human rotaviruses. After the sporadic detection in two samples in 1998, G3P[8] strains reemerged as the predominant rotavirus during 2008–2009 in Argentina. Notably, in 2011 6.3% (37/587) of samples presented the G3P[6] genotypes, which coincided with the recent detection of G3P[6] and G2P[6] strains in South America and Europe. Analyses of the 11 gene segments of four G3P[8] and two G3P[6] strains revealed that G3P[8] strains detected a decade apart (1998 and 2009) presented minor differences, while the G3P[6] strains presented a complete different genomic constellation albeit showing a similar VP7 gene. This study provides insights in the dynamics and evolution of one of the genotypes with the wider range of hosts and inter-species transmission potential.

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Rotavirus Vaccine Impact since Its Introduction in the National Immunization Program of Argentina

et al. 2022

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Introduction Rotavirus (RV) is the most common cause of childhood diarrhea. Argentina introduced RV vaccination in the National Immunization Program in January 2015. This study evaluates the impact of RV vaccine implementation on the burden of acute diarrheal disease (ADD) and RV positive cases, and hospitalizations among children in Argentina. Methods A counterfactual time-series analysis was performed. Data on ADD (2013–2018) and RV diarrhea (2012–2018) cases in children aged < 5 years were collected from the National Healthcare Surveillance System (clinical and laboratory data). Data on hospital discharges following ADD and RV diarrhea (2011–2017) were retrieved from the Health Statistics and Information Office. All data were classified by the age groups < 1 year, < 2 years, 2–5 years. Vaccine impact was defined as the difference between the predicted time trend (simulated using 2012–2014 data) and the actual post-vaccination data (2015–2018). Results A significant reduction of 22.1% of notified ADD cases and 15.4% of hospital discharges following ADD among children < 2 years was observed in the 3 years after RV vaccine implementation. Data also showed a significant decline of 54.0% and 59.4% of notified RV cases in children < 2 and < 1 years, respectively, and a reduction of 39.3% and 40.8% in RV hospital discharges for the same age groups. Conclusion This study shows a significant reduction in notified ADD cases and RV cases and hospital discharges following ADD and RV cases in children < 2 years after RV vaccine introduction in Argentina in 2015. Graphical abstract Supplementary Information The online version contains supplementary material available at 10.1007/s40121-022-00709-6.

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Rotavirus epidemiology and surveillance before vaccine introduction in Argentina, 2012–2014

Cited by 15 publications

References 32 publications

Enteric Viruses in Surface Waters from Argentina: Molecular and Viable-Virus Detection

Enteric Viruses in Surface Waters from Argentina: Molecular and Viable-Virus Detection

Genetic Diversity of G3 Rotavirus Strains Circulating in Argentina during 1998–2012 Assessed by Full Genome Analyses

Rotavirus Vaccine Impact since Its Introduction in the National Immunization Program of Argentina

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