Rotavirus infection and bradycardia-apnoea-episodes in the neonate

Riedel, Frank; Kroener, Thomas; Stein, Karin; Nuesslein, Thomas G.; Rieger, Christian

doi:10.1007/bf02115624

Cited by 20 publications

(10 citation statements)

References 24 publications

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“…Around the same time with Herrmann et al15), an association between rotavirus infection and bradycardia-apnea episodes has been reported 16). The incidence of bradycardia-apnea episodes was higher in neonates with than without rotavirus infection (33% vs. 8%, P <0.05)16).…”

Section: History Of Rotavirus As a Cause Of Neonatal Seizuresmentioning

confidence: 73%

“…Although neonates are vulnerable to seizures as well as rotavirus infection, the connection between the two in this age group has been overlooked for many years. Only a few studies have examined the association between rotavirus infection and neurological symptoms in newborns15161718). Rotavirus infection has been suggested as possible cause of 'fifth day fits' in 1990s by Herrmann et al15).…”

Section: History Of Rotavirus As a Cause Of Neonatal Seizuresmentioning

confidence: 99%

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White matter injury following rotavirus infection in neonates: new aspects to a forgotten entity, 'fifth day fits'?

Yeom

Park

2016

Korean J Pediatr

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That rotavirus infection can cause neurological symptoms in young children has been well established. However, it is surprising why rotavirus infection has been overlooked as a cause of neonatal seizures for many years, despite significant research interest in neonatal rotavirus infection. Neonates are the age group most vulnerable to seizures, which are typically attributed to a wide range of causes. By contrast, because rotavirus infection is usually asymptomatic, it has been difficult to identify an association between this virus and neonatal seizures. The conventional wisdom has been that, although neonates are commonly infected with rotavirus, neurological complications are rare in this age. However, recent studies using diffusion-weighted imaging (DWI) have suggested a connection between rotavirus infection and neonatal seizures and that rotavirus infection can induce diffuse white matter injury without direct invasion of the central nervous system. The clinical features of white matter injury in rotavirus-infected neonates include the onset of seizures at days 4–6 of life in apparently healthy term infants. The recent findings seem to contradict the conventional wisdom. However, white matter injury might not be a completely new aspect of rotavirus infection in neonates, considering the forgotten clinical entity of neonatal seizures, 'fifth day fits'. With increased use of DWI in neonatal seizures, we are just starting to understand connection between viral infection and white matter injury in neonates. In this review, we discuss the historical aspects of rotavirus infection and neonatal seizures. We also present the clinical features of white matter injury in neonatal rotavirus infection.

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Section: History Of Rotavirus As a Cause Of Neonatal Seizuresmentioning

confidence: 73%

Section: History Of Rotavirus As a Cause Of Neonatal Seizuresmentioning

confidence: 99%

White matter injury following rotavirus infection in neonates: new aspects to a forgotten entity, 'fifth day fits'?

Yeom

Park

2016

Korean J Pediatr

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“…Clusters of afebrile seizures during RV+ AGE have been reported [3,14,17,30], as well as apnea and bradycardia syndromes in newborns with RV infection [37]. RV has been detected in the cerebrospinal fluid in children with RV+ AGE who experienced seizures, and in several other body tissues [6,7,16,24,35,40].…”

Section: Introductionmentioning

confidence: 97%

Complications in hospitalized children with acute gastroenteritis caused by rotavirus: a retrospective analysis

et al. 2011

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“…Such complications include pneumonia, 3 haemophagocytic lymphohistiocytosis with encephalopathy, 4 poliomyelitis-like syndrome, 5 encephalitis, 6 central pontine myelinolysis, 7 myositis 8 and acute pancreatitis. 9 In neonates, bradycardia-apnoea episodes 10 and hypocalcaemia 11 have also been observed.…”

Section: Discussionmentioning

confidence: 96%

Fatal, rotavirus-associated myocarditis and pneumonitis in a 2-year-old boy

Grech

Calvagna

Falzon³

et al. 2001

Annals of Tropical Paediatrics

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Rotavirus infection and bradycardia-apnoea-episodes in the neonate

Abstract: RV infection was associated with a high incidence of BAE in neonates with diarrhoea during the acute phase of disease suggesting CNS involvement.

Cited by 20 publications

References 24 publications

White matter injury following rotavirus infection in neonates: new aspects to a forgotten entity, 'fifth day fits'?

White matter injury following rotavirus infection in neonates: new aspects to a forgotten entity, 'fifth day fits'?

Complications in hospitalized children with acute gastroenteritis caused by rotavirus: a retrospective analysis

Fatal, rotavirus-associated myocarditis and pneumonitis in a 2-year-old boy

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