Rotavirus Infection Frequency and Risk of Celiac Disease Autoimmunity in Early Childhood: A Longitudinal Study

Stene, Lars C.; Honeyman, Margo C.; Hoffenberg, Edward J.; Haas, Joel E.; Sokol, Ronald J.; Emery, Lisa M.; Taki, Iman; Norris, Jill M.; Erlich, Henry A.; Eisenbarth, George S.; Rewers, Marian

doi:10.1111/j.1572-0241.2006.00741.x

Cited by 494 publications

(345 citation statements)

References 28 publications

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“…[7,8] Significant interest in rotavirus as a possible infectious trigger was generated following a study by Stene et al showing that frequent rotavirus infections increased the risk of CD development in 54 cases of children under four years of age. [9] Additional case reports of CD development in children following rotavirus infection have been published. Of recent interest are the roles of IL-15 and gastrointestinal flora in the proximal small bowel in relation to precipitating disease.…”

Section: Environmental Factorsmentioning

confidence: 99%

Celiac Disease and Autoimmunity in the Gut and Elsewhere

Barton

Murray

2008

Gastroenterology Clinics of North America

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Section: Environmental Factorsmentioning

confidence: 99%

Celiac Disease and Autoimmunity in the Gut and Elsewhere

Barton

Murray

2008

Gastroenterology Clinics of North America

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“…A prospective study in children genetically predisposed to CD showed that the high frequency of rotavirus infections increased the risk of developing the disease. 14 Also a role was recently established for reovirus in the loss of gluten tolerance. 15 In the case of bacterial pathogens causing gastrointestinal infections, the development of CD was linked to previous Campylobacter spp.…”

Section: Introductionmentioning

confidence: 99%

Increased prevalence of pathogenic bacteria in the gut microbiota of infants at risk of developing celiac disease: The PROFICEL study

et al. 2018

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Celiac disease (CD) is an immune-mediated enteropathy involving genetic and environmental factors, whose interaction influences disease risk. The intestinal microbiota, including viruses and bacteria, could play a role in the pathological process leading to gluten intolerance. In this study, we investigated the prevalence of pathogens in the intestinal microbiota of infants at familial risk of developing CD. We included 127 full-term newborns with at least one first-degree relative with CD. Infants were classified according to milk-feeding practice (breastfeeding or formula feeding) and HLA-DQ genotype (low, intermediate or high genetic risk). The prevalence of pathogenic bacteria and viruses was assessed in the faeces of the infants at 7 days, 1 month and 4 months of age. The prevalence of Clostridium perfringens was higher in formula-fed infants than in breast-fed over the study period, and that of C. difficile at 4 months. Among breastfed infants, a higher prevalence of enterotoxigenic E. coli (ETEC) was found in infants with the highest genetic risk compared either to those with a low or intermediate risk. Among formula-fed infants, a higher prevalence of ETEC was also found in infants with a high genetic risk compared to those of intermediate risk. Our results show that specific factors, such as formula feeding and the HLA-DQ2 genotype, previously linked to a higher risk of developing CD, influence the presence of pathogenic bacteria differently in the intestinal microbiota in early life. Further studies are warranted to establish whether these associations are related to CD onset later in life.

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“…20 Differences in infections in early life may also be relevant. For example, in one study, 21 rotavirus infection was implicated in the development of celiac disease, a finding that requires investigation in future studies. Our findings indicate the need for study of the complex relationships among genetic, environmental, and gestational factors that may play a role in the development of celiac disease in early childhood.…”

Section: Discussionmentioning

confidence: 99%