Rotavirus infection. the possibilities of timely vaccination

Рычкова, О.А.; Grakhova, Maria A.; Сагитова, А С; Кожевникова, Лариса Анатольевна; Starostina, O.V.; Кузьмичева, К. П.

doi:10.21518/2079-701x-2018-17-215-219

Cited by 3 publications

(2 citation statements)

References 25 publications

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“…Последующие дозы -с интервалом от 4 до 10 нед. Все 3 дозы рекомендуется ввести до достижения ребенком возраста 32 нед, причем первая доза вакцины должна быть введена в возрасте 6-12 нед [25].…”

Section: вакцинация детей с нервно-мышечными болезнямиunclassified

General principles of vaccination of patients with neuromuscular diseases

Skorikov,

Vlodavets

2023

Neuromuscular Diseases

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Vaccination is recognized as the most effective, safe, and cost-effective way to prevent infectious diseases and their complications. For patients with chronic diseases, and for patients with neuromuscular diseases in particular, vaccination is the highest priority for the prevention of infectious diseases. In the current literature, there is a lack of information describing the principles of vaccination of patients with spinal muscular atrophy and Duchenne muscular dystrophy. In patients with neuromuscular diseases, full immunization has to be done in accordance with the National calendar and recommendations with the introduction of an additional vaccine against such diseases as: rotavirus infection, pneumococcal infection (using an additional dose of 23-valent vaccine), meningococcal infection, virus human papilloma, respiratory viral infection. syncytial virus and influenza. In this regard, of particular importance is the development of recommendations describing the schemes for the use of vaccines in children suffering from spinal muscular atrophy and Duchenne muscular dystrophy.

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Section: вакцинация детей с нервно-мышечными болезнямиunclassified

General principles of vaccination of patients with neuromuscular diseases

Skorikov,

Vlodavets

2023

Neuromuscular Diseases

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“…2021; 66(2) DOI: https://doi.org/10.36233/0507-4088-46 ОРИГИНАЛЬНЫЕ ИССЛЕДОВАНИЯ На территории Российской Федерации зарегистрирована живая аттенуированная пентавалентная вакцина (RV5). В 2014 г. она включена во вторую часть национального календаря профилактических прививок (по эпидемическим показаниям), а в ряде субъектов (Москва, Краснодар, Свердловская область, Смоленск, Тюмень, Ярославль, Владивосток, Санкт-Петербург, Сахалин) -в региональные календари [3]. В 2014-2018 гг.…”

Section: Introductionunclassified

Molecular monitoring of the rotavirus (<i>Reoviridae: Sedoreovirinae: Rotavirus: Rotavirus A</i>) strains circulating in Nizhny Novgorod (2012–2020): detection of the strains with the new genetic features

Сашина

Морозова

Епифанова

et al. 2021

Problems of Virology

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Introduction. The pentavalent rotavirus vaccine has been registered in Russia, however, the vaccination coverage remains low, and an annual increase in the incidence of rotavirus infection is unavoidable. In this regard, molecular monitoring of rotaviruses in order to search for new variants possessing epidemic potential is an urgent task. Material and methods. PCR genotyping and VP4 and VP7 genes sequencing were used to characterize rotaviruses circulating in Nizhny Novgorod in 2012–2020. The phylogenetic analysis of the strains was carried out using the BEAST software package.Results. The spectrum included 17 genotypes with predominance of G9P[8] (37,4%). Detected in this study genotypes G1P[4], G1P[9], G2P[8], G4P[4], G4P[6], G8P[8], and G9P[4] were not previously identified in Nizhny Novgorod. The circulation of DS-1-like strains possessing genotypes G1P[8], G3P[8], G8P[8], or G9P[8] and a short RNA pattern had been shown. Rotaviruses of the common genotypes were genetically heterogeneous and belonged to different phylogenetic lineages and/or sublineages (P[4]-IV-a; P[4]-IV-b; P[8]-3.1; P[8]-3.3; P[8]-3.4 and P[8]-3.6; G1-I; G1-II; G2-IVa-1; G2-IVa-3; G3-1; G3-3; G4-I-c; G9-III; G9-VI).Discussion. These results extend the available data on the genotypic structure of rotavirus populations in Russia and show the genetic diversity of viral strains. G3P[8] DS-1-like viruses were representatives of the G3-1 lineage, new for the territory of Russia, and had the largest number of amino acid substitutions in the VP7 antigenic epitopes.Conclusion. The emergence and spread of strains with new genetic features may allow rotavirus to overcome the immunological pressure formed by natural and vaccine-induced immunity, and maintain or increase the incidence of rotavirus infection.

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