Rotavirus surveillance to determine disease burden and epidemiology in Java, Indonesia, August 2001 through April 2004

Wilopo, Siswanto Agus; Soenarto, Yati; Bresee, Joseph S.; Tholib, Abu; Aminah, Sri; Cahyono, Anton; Gentsch, Jon R.; Kilgore, Paul E.; Glass, Roger I.

doi:10.1016/j.vaccine.2009.09.004

Cited by 13 publications

(17 citation statements)

References 24 publications

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“…These symptoms could increase the risk of dehydration and hospitalization. Although there appears to be an increasing trend in admitting young children with diarrhea, this appears to be associated with a low mortality, possibly because of better hospital clinical management [6]. …”

Section: Discussionmentioning

confidence: 99%

“…A study in Indonesia showed a clear seasonal trend of rotavirus infection in the hot and dry seasons with low humidity [6,17]. Another study in India found that 64.8% of rotavirus cases occurred in the cooler months i.e., from November to January.…”

Section: Discussionmentioning

confidence: 99%

“…An estimated 527,000 children aged <5 years died from rotavirus infection in 2004 with > 85% of these deaths in South-East Asia and sub-Saharan Africa [5]. Of 8929 Indonesian children in Purworejo district and Yogyakarta city hospitalized between August 2001 and April 2004, 16% presented with acute gastroenteritis, and 53% of the 1321 tested stool samples were positive for rotavirus [6]. …”

Section: Introductionmentioning

confidence: 99%

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Risk factors of rotavirus diarrhea in hospitalized children in Sanglah Hospital, Denpasar: a prospective cohort study

et al. 2014

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BackgroundDiarrhea is a major public health concern throughout the world because the prevalence of morbidity of diarrhea has not changed significantly in the past decade. It remains the third leading cause of death among children less than 5 years of age. Recent surveillance studies have shown that rotavirus is a significant cause of pediatric hospitalization and death due to diarrhea. Indonesia has limited data on risk factors, disease burden, and deaths in children due to rotavirus diarrhea. The objective of this study was to examine the above mentioned factors related to rotavirus diarrhea in hospitalized children in Sanglah Hospital, Denpasar.MethodsA prospective cohort study was conducted at Sanglah Hospital Denpasar from April 2009 to December 2011. The present study was part of a nationwide study on Extension for Hospital-based Surveillance and Strain Characterization of Rotavirus Diarrhea Indonesia involving four hospitals throughout Indonesia as a part of the Asian Rotavirus Surveillance Network. We studied children aged <5 years who were hospitalized with acute diarrhea, and analyzed their stool samples using an immunoassay that detects the rotavirus antigen.ResultsA total of 656 patients met the inclusion criteria for this study. Of 5805 patients under the age of 5 who were hospitalized between April 2009 and December 2011, the prevalence of diarrhea among hospitalized pediatric patients was 11.3% and the prevalence of rotavirus diarrhea was 49.8%. The male to female ratio of those affected by rotavirus was 1.6:1. The occurrence of vomiting was significantly higher in rotavirus diarrhea than in non-rotavirus diarrhea (RR, 1.4; 95% CI, 1.08 to 1.70; p = 0.004).ConclusionsDiarrhea remains an important cause of hospitalization in children, and rotavirus was the most important etiology. We found that boys had a greatest risk of rotavirus infection than girls. Good nutritional status and breastfeeding provided the same protection against rotavirus and non-rotavirus diarrhea.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Risk factors of rotavirus diarrhea in hospitalized children in Sanglah Hospital, Denpasar: a prospective cohort study

et al. 2014

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“…Our study was conducted in a rainy season (November – April), which was assumed to be the peak of diarrhea prevalence as described in a previous study within a similar community [32]. However, some recent studies in developing countries observed high diarrhea prevalence in dry seasons [33-37]. Performing the study in a rainy season may lead to an overestimation of diarrhea prevalence because there is a strong link between diarrheal illnesses and weather- and climate-related events.…”

Section: Discussionmentioning

confidence: 99%

Association of food-hygiene practices and diarrhea prevalence among Indonesian young children from low socioeconomic urban areas

et al. 2013

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BackgroundInformation on the part that poor food-hygiene practices play a role in the development of diarrhea in low socioeconomic urban communities is lacking. This study was therefore aimed at assessing the contribution of food-hygiene practice to the prevalence of diarrhea among Indonesian children.MethodsA cross-sectional study was conducted among 274 randomly selected children aged 12–59 months in selected low socioeconomic urban areas of East Jakarta. The prevalence of diarrhea was assessed from 7-day records on frequency and consistency of the child’s defecation pattern. Food-hygiene practices including mother’s and child’s hand washing, food preparation, cleanliness of utensils, water source and safe drinking water, habits of buying cooked food, child’s bottle feeding hygiene, and housing and environmental condition were collected through home visit interviews and observations by fieldworkers. Thirty-six practices were scored and classified into poor (median and below) and better (above median) food-hygiene practices. Nutritional status of children, defined anthropometrically, was measured through height and weight.ResultsAmong the individual food-hygiene practices, children living in a house with less dirty sewage had a significantly lower diarrhea prevalence compared to those who did not [adjusted odds ratio (OR) 0.16, 95% confidence interval (CI) = 0.03-0.73]. The overall food-hygiene practice score was not significantly associated with diarrhea in the total group, but it was in children aged < 2 years (adjusted OR 4.55, 95% CI = 1.08-19.1).ConclusionsOverall poor mother’s food-hygiene practices did not contribute to the occurrence of diarrhea in Indonesian children. However, among children < 2 years from low socioeconomic urban areas they were associated with more diarrhea.

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“…Indonesia is among the South‐East Asian countries with a high burden of rotavirus diarrhea‐related deaths . As a member of the Asian Rotavirus Surveillance Network, a national surveillance program was established to monitor the circulation of rotavirus strains in the country . The national surveillance conducted in 2006, and between 2009 and 2015 showed that rotavirus was responsible for approximately 47.5%‐52.0% of hospital admissions due to acute diarrhea in children under 5 years of age .…”

Section: Introductionmentioning

confidence: 99%

Phylogenetic and immunoinformatic analysis of VP4, VP7, and NSP4 genes of rotavirus strains circulating in children with acute gastroenteritis in Indonesia

Nirwati

Donato

Ikram

et al. 2019

Journal of Medical Virology

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Rotavirus is a major cause of diarrhea in Indonesian children. However, rotavirus vaccines have not been introduced in the national immunization program of Indonesia. Understanding the genetic diversity and conserved antigenic regions of circulating strains are therefore essential to assess the potential efficacy of rotavirus vaccines. We collected fecal samples from hospitalized children less than 5 years of age with acute diarrhea. Rotavirus genotyping was performed by reverse transcriptase polymerase chain reaction, followed by sequencing of the VP4, VP7, and NSP4 genes of representative strains. Phylogenetic analysis was performed to investigate their relationship with globally circulating strains. Conservational analysis, immunoinformatics, and epitope mapping in comparison to vaccine strains were also performed. The sequence analyses showed that differences of multiple amino acid residues existed between the VP4, VP7, and NSP4 antigenic regions of the vaccine strains and the Indonesian isolates. However, many predicted conserved epitopes with higher antigenicity were observed in the vaccine and Indonesian strains, conferring the importance of these epitopes. The identified epitopes showed a higher potential of rotavirus vaccine to be employed in Indonesia. It could also be helpful to inform the design of a peptide vaccine based on the conserved regions and epitopes in the viral proteins.

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Rotavirus surveillance to determine disease burden and epidemiology in Java, Indonesia, August 2001 through April 2004

Cited by 13 publications

References 24 publications

Risk factors of rotavirus diarrhea in hospitalized children in Sanglah Hospital, Denpasar: a prospective cohort study

Risk factors of rotavirus diarrhea in hospitalized children in Sanglah Hospital, Denpasar: a prospective cohort study

Association of food-hygiene practices and diarrhea prevalence among Indonesian young children from low socioeconomic urban areas

Phylogenetic and immunoinformatic analysis of VP4, VP7, and NSP4 genes of rotavirus strains circulating in children with acute gastroenteritis in Indonesia

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