Rotavirus vaccine series completion and adherence to vaccination schedules among infants in managed care in the United States

Krishnarajah, Girishanthy; Davis, Elizabeth; Fan, Ying; Standaert, Baudouin; Buikema, Ami

doi:10.1016/j.vaccine.2011.12.077

Cited by 20 publications

(43 citation statements)

References 17 publications

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“…Only 2% of the children that received a first dose of rotavirus vaccine did not complete their schedule. The proportion of children who completed their vaccination series in Flanders is somewhat larger than the reported proportion based on US health insurance claims for under one year-olds, where 9% of the children immunised with the monovalent vaccine missed a final dose, and 16.6% of the children who received a first dose of the pentavalent vaccine did not complete their schedule [14]. In our study it was not possible to distinguish between vaccine brands; therefore we might have misinterpreted the completeness of the vaccination schedule, since two doses (considered as fully vaccinated in our study) might have been an incomplete vaccination schedule with Rotateq (needing three doses to be complete).…”

Section: Discussionmentioning

confidence: 69%

Rotavirus vaccination coverage and adherence to recommended age among infants in Flanders (Belgium) in 2012

et al. 2014

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In Belgium, rotavirus vaccination has been recommended and partially reimbursed since October 2006. Through a retrospective survey in 2012, we estimated the coverage rate of the rotavirus vaccination in Flanders among infants born in 2010. Using a standardised questionnaire, 874 families were interviewed at home, collecting information on demographic characteristics, socio-economic background and documented vaccination history (updated from medical files and vaccination database, if needed). Adherence to the recommended age for vaccination (8, 12 and 16 weeks) was also assessed. The coverage rate for two doses of rotavirus vaccination was 92.2% (95% confidence interval: 90.2-93.8). Respectively 31.7% and 10.1% of the children received their first and second dose at the recommended age. Incomplete vaccination was often a deliberate choice of the parents. Only eight children (1%) were vaccinated after the maximum age of 26 weeks. Factors identified by multiple logistic regression as related to incomplete vaccination were: living in the province of Antwerp, unemployed mother, and three or more older siblings in the household. Four years after introduction, the coverage rates were surprisingly high for a vaccine that is not fully reimbursed and not readily available in the vaccinator's fridge, which is the case for the other recommended infant vaccines.

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Section: Discussionmentioning

confidence: 69%

Rotavirus vaccination coverage and adherence to recommended age among infants in Flanders (Belgium) in 2012

et al. 2014

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“…Overall, 61.2% of the population were compliant with the PI dosing schedules (RV1 75.0% vs. RV5 59.5%; p < 0.001) and 77.2% were compliant with the ACIP dosing schedule (RV1 83.3% vs. RV5 76.4%; p < 0.001). Completion rate, defined as receiving all doses but not necessarily on schedule, was 84.3% (RV1 91.0% vs. RV5 83.4%; p < 0.001) [10]. Two recent studies on privately insured children also found higher compliance and completion rates among children receiving RV1 than those receiving RV5 [11,12].…”

Section: Introductionmentioning

confidence: 90%

“…Recent studies also evaluated the rates of adherence (i.e., compliance) to both the ACIP and FDA-approved dosing schedules for RV1 and RV5 among infants in the US. One study included infants less than one year of age enrolled in managed care plans and initiating RV vaccination during the months January to June of 2009 [10]. Overall, 61.2% of the population were compliant with the PI dosing schedules (RV1 75.0% vs. RV5 59.5%; p < 0.001) and 77.2% were compliant with the ACIP dosing schedule (RV1 83.3% vs. RV5 76.4%; p < 0.001).…”

Section: Introductionmentioning

confidence: 99%

Rotavirus vaccination compliance and completion in a Medicaid infant population

Krishnarajah¹,

Landsman-Blumberg²,

Eynullayeva³

2015

Vaccine

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We examined completion and compliance rates of rotavirus (RV) vaccination according to the recommendations of the Advisory Committee on Immunization Practices (ACIP) and the Food and Drug Administration approved Prescribing Information (PI) for Rotarix® (RV1, GlaxoSmithKline Vaccines) and RotaTeq® (RV5, Merck and Co.) among infants under one year of age covered by Medicaid programs. Healthcare claims data from state Medicaid programs that constituted the Truven Health MarketScan® Multi-State Medicaid Database were retrieved from May 2008-June 2012. Infants were grouped under PI and ACIP cohorts based on the dosing regimens followed. The overall compliance per PI (n=673,956) and ACIP (n=695,612) recommendations were 24.5% and 28.2%, respectively; completion rates were 30.3% and 32.6%, respectively. In the PI cohort, infants who received RV1 had significantly higher compliance as compared with infants who received RV5 (65.2% vs. 31.3%; p<0.0001); completion rates among infants receiving RV1 and RV5 were 65.3% and 46.4%, respectively (p<0.0001). In the ACIP cohort, compliance with RV1 was significantly higher than RV5 (68.8% vs. 45.9%; p<0.0001) as was the overall completion rate (73.5% vs. 48.8%; p<0.0001). While compliance is increasing year over year, overall compliance of RV vaccines is suboptimal, with over 40% of eligible infants unvaccinated in both populations. The 2-dose RV vaccine showed better completion rates and higher compliance than the 3-dose RV vaccine in the United States. Public health initiatives focusing on suboptimal compliance and completion rates of RV vaccination in the Medicaid population could improve these metrics, thereby offering protection against RV infection.

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“…Because the majority of US rotavirus vaccinations are RV5, any rotavirus vaccinations of unknown brand in the medical record were assumed to be RV5 [15].…”

Section: Discussionmentioning

confidence: 99%

Accuracy of administrative claims data to identify dose specific rotavirus vaccination information: Implications for studies of vaccine safety

Quinlan

Lanes

Holick

et al. 2015

Vaccine

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Rotavirus vaccine series completion and adherence to vaccination schedules among infants in managed care in the United States

Cited by 20 publications

References 17 publications

Rotavirus vaccination coverage and adherence to recommended age among infants in Flanders (Belgium) in 2012

Rotavirus vaccination coverage and adherence to recommended age among infants in Flanders (Belgium) in 2012

Rotavirus vaccination compliance and completion in a Medicaid infant population

Accuracy of administrative claims data to identify dose specific rotavirus vaccination information: Implications for studies of vaccine safety

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